A Study of Subcutaneous Mircera, Versus no Erythropoiesis-Stimulating Agent (ESA) Therapy, in the Treatment of Anemia in Patients With Chronic Kidney Disease After Kidney Transplant

NCT ID: NCT00576602

Last Updated: 2016-11-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

PHASE4

Total Enrollment

1 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-12-31

Study Completion Date

2008-07-31

Brief Summary

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This 2 arm study will assess the efficacy, safety and tolerability of subcutaneous Mircera, versus no ESA therapy, in chronic kidney disease patients with anemia after kidney transplant, not currently treated with ESA. Patients will be randomized to receive a)subcutaneous Mircera at a recommended starting dose of 0.6 micrograms/kg every 2 weeks, switching to monthly treatment at week 16 or b)supportive treatment (eg. iron supplementation) for management of low hemoglobin concentrations. The anticipated time on study treatment is 3-12 months, and the target sample size is 100-500 individuals.

Detailed Description

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Conditions

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Anemia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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1

Group Type EXPERIMENTAL

methoxy polyethylene glycol-epoetin beta [Mircera]

Intervention Type DRUG

Recommended starting dose of 0.6 micrograms/kg sc every 2 weeks

2

Group Type ACTIVE_COMPARATOR

Supportive treatment

Intervention Type DRUG

As prescribed

Interventions

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methoxy polyethylene glycol-epoetin beta [Mircera]

Recommended starting dose of 0.6 micrograms/kg sc every 2 weeks

Intervention Type DRUG

Supportive treatment

As prescribed

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* adult patients, \>=18 years of age;
* kidney transplant \>=6 months and \<5 years prior to randomization;
* anemia;
* no ESA therapy during 3 months prior to randomization.

Exclusion Criteria

* requirement for hemodialysis or peritoneal dialysis within 3 months prior to randomization;
* change in Hb concentration \>=1.5g/dL during screening period;
* transfusion of red blood cells during 3 months prior to randomization;
* poorly controlled hypertension;
* significant acute or chronic bleeding within 3 months prior to randomization.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hoffmann-La Roche

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Clinical Trials

Role: STUDY_DIRECTOR

Hoffmann-La Roche

Locations

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Edegem, , Belgium

Site Status

Ghent, , Belgium

Site Status

Leuven, , Belgium

Site Status

Amiens, , France

Site Status

Caen, , France

Site Status

Le Kremlin-Bicêtre, , France

Site Status

Nice, , France

Site Status

Paris, , France

Site Status

Toulouse, , France

Site Status

Tours, , France

Site Status

Berlin, , Germany

Site Status

Frankfurt am Main, , Germany

Site Status

Kaiserslautern, , Germany

Site Status

Kiel, , Germany

Site Status

München, , Germany

Site Status

Bari, , Italy

Site Status

Barcelona, , Spain

Site Status

Santander, , Spain

Site Status

Seville, , Spain

Site Status

London, , United Kingdom

Site Status

Countries

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Australia Brazil Hungary Poland Belgium France Germany Italy Spain United Kingdom

Other Identifiers

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MH21299

Identifier Type: -

Identifier Source: org_study_id