OP Device vs. Bone Autograft for the Treatment of Tibial Nonunions

NCT ID: NCT00679328

Last Updated: 2011-06-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

122 participants

Study Classification

INTERVENTIONAL

Study Start Date

1992-02-29

Study Completion Date

1999-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This study is to evaluate the safety and effectiveness of the OP device for the treatment of nonunion bone fractures and to compare the healing rates of the OP Device to that of autograft.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

This study is to evaluate the safety and effectiveness of the OP device for the treatment of nonunion bone fractures and to compare the clinical safety and effectiveness (healing rates) of the OP Device to that of traditional bone autografts to repair nonunions.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Tibial Nonunions

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

1

Surgical implantation of OP-1

Group Type EXPERIMENTAL

Surgical implantation of OP-1 device or autograft bone graft material

Intervention Type DEVICE

Surgical implantation of OP-1 device or autograft bone graft material

2

Surgical implantation of bone graft material

Group Type ACTIVE_COMPARATOR

Surgical implantation of OP-1 device or autograft bone graft material

Intervention Type DEVICE

Surgical implantation of OP-1 device or autograft bone graft material

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Surgical implantation of OP-1 device or autograft bone graft material

Surgical implantation of OP-1 device or autograft bone graft material

Intervention Type DEVICE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

1. Patients must show radiographic skeletal maturity
2. Documented evidence of previous fracture management
3. Nonunion in the tibia and candidate to receive bone autografts and intramedullary (IM) Nail fixation
4. Nonunion gap must not exceed half the diameter of the bone at the site of fracture, as assessed radiographically prior to study treatment

Exclusion Criteria

1. Patients who do not have adequate vascularity to permit healing
2. Patients with inadequate skin coverage
3. Patients with chronic use of steroidal medications
4. Patients with active infection systemically or at the site of nonunion.
Minimum Eligible Age

18 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Olympus Biotech Corporation

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Olympus Biotech

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Mesa, Arizona, United States

Site Status

Modesto, California, United States

Site Status

San Diego, California, United States

Site Status

Stanford, California, United States

Site Status

Denver, Colorado, United States

Site Status

Fort Carson, Colorado, United States

Site Status

Miami, Florida, United States

Site Status

Orlando, Florida, United States

Site Status

Atlanta, Georgia, United States

Site Status

New Orleans, Louisiana, United States

Site Status

Detroit, Michigan, United States

Site Status

St Louis, Missouri, United States

Site Status

New York, New York, United States

Site Status

Cleveland, Ohio, United States

Site Status

Philadelphia, Pennsylvania, United States

Site Status

Providence, Rhode Island, United States

Site Status

Galveston, Texas, United States

Site Status

Lubbock, Texas, United States

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

TR-0056

Identifier Type: -

Identifier Source: secondary_id

91-01

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Allograft vs. Autograft Nonunion
NCT07310082 NOT_YET_RECRUITING NA