ABT-335 (Choline Fenofibrate) Reverse Cholesterol Transport (RCT) Study

NCT ID: NCT00673881

Last Updated: 2011-04-20

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE1/PHASE2
• Total Enrollment: 25 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2008-03-31
• Study Completion Date: 2009-05-31

Brief Summary

The objectives of the study are:

1. To evaluate the effect of ABT-335 (choline fenofibrate) on several parameters of RCT (reverse cholesterol transport) in men and post-menopausal women diagnosed with dyslipidemia (i.e., low high-density lipoprotein [HDL] cholesterol levels and elevated triglyceride [TG] concentrations).

2. To evaluate longitudinal changes in several parameters of RCT in subjects with low HDL.

3. To obtain pilot data for power calculations for subsequent comparative study.

Detailed Description

This trial assesses the effects of ABT-335 on RCT as measured by cholesterol efflux or rate of appearance of cholesterol (Ra in mg/kg/hr), cholesterol excretion (%/day), RCT efflux (mg/kg/day) and de novo cholesterol synthesis (%) during a baseline period (7 days) and during a treatment period (94 days).

The goal of using RCT to reverse atherosclerosis is to increase the rate of cholesterol export or "efflux" from the tissues and plaques. An increase in this cholesterol efflux rate should shrink arterial plaques by decreasing their static accumulation of cholesterol. While some currently marketed drugs have a positive impact on RCT by increasing the rate of cholesterol excretion from the body, no drug has yet been approved to increase the rate of cholesterol efflux from the tissues

Conditions

Dyslipidemia

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Abt-335

ABT-335 (choline fenofibrate)

Group Type: EXPERIMENTAL

choline fenofibrate

Intervention Type: DRUG

135 mg choline fenofibrate daily(oral, capsule)

Interventions

choline fenofibrate

135 mg choline fenofibrate daily(oral, capsule)

Intervention Type: DRUG

Other Intervention Names

ABT-335

Eligibility Criteria

Inclusion Criteria

1. Male, non-smoker, 21 - 75 years of age inclusive.

2. Female, non-smoker, 40 - 75 years of age inclusive.

3. Post-menopausal women, as defined by lack of menses for at least 2 years and age > 55, OR history of documented bilateral surgical oophorectomy, confirmed with an elevated follicle-stimulating hormone (FSH) at screening.

4. HDL concentration (≤ 50 mg/dl women, ≤ 40mg/dl men)

5. TG concentration 150-500 mg/dl, inclusive

6. Ability to give informed consent

Exclusion Criteria

1. Subject has history of diabetes mellitus, active hepatitis, gall bladder disease, gastric bypass surgery, or clinically significant abnormalities on screening (prestudy) physical examination or laboratory tests.

2. Screening laboratory tests with hematocrit <30%, aspartate aminotransferase (AST)/alanine aminotransferase (ALT) > 2X upper limit of normal, abnormal thyroid-stimulating hormone (TSH), fasting glucose ≥126 mg/dl.

3. Renal impairment with creatinine clearance < 80 ml/min.

4. Treatment within the last 6 months with drugs known to alter lipid metabolism including beta blockers, thiazide diuretics, bile acid resins, ezetimibe, fibrates, niacin, and fish oils (see Appendix 1). Washout of fibrates is not permitted.

5. Treatment with drugs known to interact with ABT-335, e.g., warfarin (see Appendix 1).

6. Treatment with HMG CoA reductase inhibitors (statins) within the past 4 weeks (see Appendix 1).

7. History of allergy to egg or soy products.

8. History of coronary heart disease (CHD), stroke or revascularization procedure in the six months prior to Visit 1.

9. Current or recent history (past 12 months) of drug abuse or alcohol abuse. Alcohol abuse will be defined as >14 drinks per week (1 drink = 12 oz beer, 5 oz wine, or 1.5 oz hard liquor).

10. Participation in another clinical trial or exposure to any investigational agent within 30 days before visit 1.

11. Individual has a condition the Principal Investigator believes would interfere with his/her ability to provide informed consent, comply with study instructions, or which might confound the interpretation of the study results or put the subject at undue risk.

• Minimum Eligible Age: 21 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Radiant Research

OTHER

Sponsor Role: lead

Responsible Party

Radiant Research

Principal Investigators

Michael H Davidson, MD,FACC

Role: PRINCIPAL_INVESTIGATOR

Radiant Research

Locations

Radiant Research, 515 N State St, #2700

Chicago, Illinois, United States

Countries

United States

Other Identifiers

ABT-335-001

Identifier Type: -

Identifier Source: org_study_id