Safety and Efficacy Study Comparing ABT-335 Coadministered With Atorvastatin and Ezetimibe to Atorvastatin Coadministered With Ezetimibe in Subjects With Multiple Abnormal Lipid (Fat) Levels in the Blood

NCT ID: NCT00639158

Last Updated: 2011-06-13

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

543 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-02-29

Brief Summary

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The primary purpose of this study is to compare the safety and efficacy of ABT-335 (investigational drug) coadministered with atorvastatin and ezetimibe to atorvastatin coadministered with ezetimibe in subjects with abnormal lipid (fat) levels in the blood.

Detailed Description

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Conditions

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Dyslipidemias Coronary Heart Disease Combined (Atherogenic) Dyslipidemia Mixed Dyslipidemia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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ABT-335 + atorvastatin + ezetimibe

Group Type ACTIVE_COMPARATOR

ABT-335

Intervention Type DRUG

135 mg capsule, daily, 12 weeks

atorvastatin

Intervention Type DRUG

40 mg, tablet, daily, 12 weeks

ezetimibe

Intervention Type DRUG

10 mg capsule, daily, 12 weeks

Placebo + atorvastatin + ezetimibe

Group Type PLACEBO_COMPARATOR

placebo

Intervention Type DRUG

placebo capsule, daily, 12 weeks

atorvastatin

Intervention Type DRUG

40 mg, tablet, daily, 12 weeks

ezetimibe

Intervention Type DRUG

10 mg capsule, daily, 12 weeks

Interventions

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ABT-335

135 mg capsule, daily, 12 weeks

Intervention Type DRUG

placebo

placebo capsule, daily, 12 weeks

Intervention Type DRUG

atorvastatin

40 mg, tablet, daily, 12 weeks

Intervention Type DRUG

ezetimibe

10 mg capsule, daily, 12 weeks

Intervention Type DRUG

Other Intervention Names

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TriLipix Fenofibric acid Choline Fenofibrate Lipitor Ezetrol Zetia Ezemibe

Eligibility Criteria

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Inclusion Criteria

* Subjects with mixed dyslipidemia (trigylcerides, \> or = to 150 mg/dL to \< 400 mg/dL; HDL-C \< 40 mg/dL for males, \< 50 mg/dL for females; LDL-C, \> or = to 130 mg/dL).
* Subjects must agree to use adequate birth control methods and to adhere to the American Heart Association (AHA) Diet.

Exclusion Criteria

* Subjects with unstable or uncontrolled medical conditions considered inappropriate in a clinical trial.
* Subjects with an unstable dose of medications or receiving Coumadin, oral, intravenous or intramuscular cyclosporine, statins, or certain other medications.
* Women who are pregnant or plan on becoming pregnant, or women who are lactating.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Abbott

INDUSTRY

Sponsor Role lead

Responsible Party

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Abbott

Locations

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Birmingham, Alabama, United States

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Columbiana, Alabama, United States

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Hueytown, Alabama, United States

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Ozark, Alabama, United States

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Tuscaloosa, Alabama, United States

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Sierra Vista, Arizona, United States

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Hot Springs, Arkansas, United States

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Carmichael, California, United States

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Concord, California, United States

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Long Beach, California, United States

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Long Beach, California, United States

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Los Angeles, California, United States

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Norwalk, California, United States

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Roseville, California, United States

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Sacramento, California, United States

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Santa Ana, California, United States

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Tustin, California, United States

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West Hills, California, United States

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Colorado Springs, Colorado, United States

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Denver, Colorado, United States

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Clearwater, Florida, United States

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Delray Beach, Florida, United States

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Fort Myers, Florida, United States

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Holly Hill, Florida, United States

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Jacksonville, Florida, United States

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Jacksonville, Florida, United States

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Kissimmee, Florida, United States

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Longwood, Florida, United States

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Miami, Florida, United States

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New Port Richey, Florida, United States

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New Smyrna Beach, Florida, United States

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Ocala, Florida, United States

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Ormond Beach, Florida, United States

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Pembroke Pines, Florida, United States

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Sarasota, Florida, United States

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Tampa, Florida, United States

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Winter Haven, Florida, United States

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Atlanta, Georgia, United States

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Augusta, Georgia, United States

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Roswell, Georgia, United States

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Suwanee, Georgia, United States

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Woodstock, Georgia, United States

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Boise, Idaho, United States

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Chicago, Illinois, United States

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Chicago, Illinois, United States

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Peoria, Illinois, United States

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Evansville, Indiana, United States

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Evansville, Indiana, United States

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Indianapolis, Indiana, United States

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Iowa City, Iowa, United States

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Arkansas City, Kansas, United States

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Overland Park, Kansas, United States

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Wichita, Kansas, United States

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Louisville, Kentucky, United States

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Mount Sterling, Kentucky, United States

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Slidell, Louisiana, United States

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Baltimore, Maryland, United States

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Oxon Hill, Maryland, United States

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Brockton, Massachusetts, United States

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Edina, Minnesota, United States

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Olive Branch, Mississippi, United States

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City of Saint Peters, Missouri, United States

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St Louis, Missouri, United States

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St Louis, Missouri, United States

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Billings, Montana, United States

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Las Vegas, Nevada, United States

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Berlin, New Jersey, United States

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Elizabeth, New Jersey, United States

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Hillsborough, New Jersey, United States

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Trenton, New Jersey, United States

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Johnson City, New York, United States

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Charlotte, North Carolina, United States

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Hickory, North Carolina, United States

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Morehead City, North Carolina, United States

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Raleigh, North Carolina, United States

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Salisbury, North Carolina, United States

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Statesville, North Carolina, United States

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Winston-Salem, North Carolina, United States

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Cincinnati, Ohio, United States

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Mason, Ohio, United States

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Mogadore, Ohio, United States

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Warren, Ohio, United States

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Tulsa, Oklahoma, United States

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Hillsboro, Oregon, United States

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Duncansville, Pennsylvania, United States

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Harleysville, Pennsylvania, United States

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Jersey Shore, Pennsylvania, United States

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Lansdale, Pennsylvania, United States

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Melrose Park, Pennsylvania, United States

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Newtown, Pennsylvania, United States

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Perkasie, Pennsylvania, United States

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Philadelphia, Pennsylvania, United States

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Philadelphia, Pennsylvania, United States

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Pittsburgh, Pennsylvania, United States

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Sellersville, Pennsylvania, United States

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Tipton, Pennsylvania, United States

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Warminster, Pennsylvania, United States

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Cumberland, Rhode Island, United States

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Anderson, South Carolina, United States

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Greenville, South Carolina, United States

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Greer, South Carolina, United States

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Simpsonville, South Carolina, United States

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Summerville, South Carolina, United States

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Nashville, Tennessee, United States

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Dallas, Texas, United States

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Fort Worth, Texas, United States

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Houston, Texas, United States

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San Antonio, Texas, United States

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Salt Lake City, Utah, United States

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Salt Lake City, Utah, United States

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Salt Lake City, Utah, United States

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West Jordan, Utah, United States

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Norfolk, Virginia, United States

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Richmond, Virginia, United States

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Roanoke, Virginia, United States

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Virginia Beach, Virginia, United States

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Spokane, Washington, United States

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Madison, Wisconsin, United States

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Countries

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United States

References

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Jones PH, Goldberg AC, Knapp HR, Kelly MT, Setze CM, Stolzenbach JC, Sleep DJ. Efficacy and safety of fenofibric acid in combination with atorvastatin and ezetimibe in patients with mixed dyslipidemia. Am Heart J. 2010 Oct;160(4):759-66. doi: 10.1016/j.ahj.2010.06.045.

Reference Type DERIVED
PMID: 20934572 (View on PubMed)

Other Identifiers

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M10-275

Identifier Type: -

Identifier Source: org_study_id

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