Agreement Between Spectral Domain and Time Domain Optical Coherence Tomography (OCT)
NCT ID: NCT00651989
Last Updated: 2008-04-03
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
40 participants
OBSERVATIONAL
2008-04-30
2008-05-31
Brief Summary
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In our study in healthy subjects foveal thickness will be measured with both TD and SD OCT , and the data will be compared to evidence any difference between the two retinal measurements techniques.
Detailed Description
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Time domain optical coherence tomography images will be obtained from each eye after pupil dilation using the Stratus OCT system (version 4.1. Carl Zeiss Meditec, Dublin, CA).
Spectral domain optical coherence tomography images will be obtained using the HRA-OCT Spectralis unit (Heidelberg Engineering GmbH, Heidelberg, Germany).
All data will be analyzed with the statistical package MedCalc® version 8.1 for Windows (MedCalc®, Mariakerke, Belgium).
The D'Agostino-Pearson test that computes a single P-value for the combination of the coefficients of Skewness and Kurtosis will be used to study the sample distribution.
T-test will be used to compare means between Stratus and Spectralis measurements and orizontal and vertical measurements.
To assess agreement between Spectralis and Stratus OCT foveal measurements the Bland and Altman plots of the agreement in foveal thickness will be used. For both orizontal and vertical foveal measurements the ratio (Spectralis/stratus OCT foveal thickness) will be plotted against the average of the two measurements.
Conditions
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Keywords
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Study Design
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COHORT
CROSS_SECTIONAL
Study Groups
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A
healthy individuals
optical coherence tomography foveal thickness measurement
In the same session in one randomly selected eye of each subject three consecutive measurements of foveal thickness were performed using both time-domain OCT and spectral-domain OCT.
Interventions
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optical coherence tomography foveal thickness measurement
In the same session in one randomly selected eye of each subject three consecutive measurements of foveal thickness were performed using both time-domain OCT and spectral-domain OCT.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* previous ocular surgery or laser treatment
* any systemic or ocular therapy
19 Years
30 Years
ALL
Yes
Sponsors
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G. d'Annunzio University
OTHER
Responsible Party
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Dept. of Medicine and Aging Sciences, University "G. d'Annunzio" Chieti-Pescara
Principal Investigators
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Paolo Carpineto, M.D.
Role: PRINCIPAL_INVESTIGATOR
Dept. of Medicine and Aging Sciences, Univ. "G. d'Annunzio" Chieti-Pescara
Locations
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Ophthalmology Clinic, Univ. "G. d'Annunzio" Chieti-Pescara
Chieti, , Italy
Countries
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Central Contacts
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References
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Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet. 1986 Feb 8;1(8476):307-10.
Other Identifiers
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Ud'A-Ophtha-001
Identifier Type: -
Identifier Source: org_study_id