Systemic Reactions to Allergen Immunotherapy Amd Skin Testing
NCT ID: NCT00594802
Last Updated: 2010-08-09
Study Results
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Basic Information
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COMPLETED
100 participants
OBSERVATIONAL
2006-08-31
2007-06-30
Brief Summary
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The systemic reaction rate to skin testing for aeroallergens is significant lower than the rate of reactions to immunotherapy, but it is not negligible. Lin et al reported only 2 patients who had systemic allergic reactions to skin testing for respiratory allergies in 10,400 patients tested.3 They determined the overall risk of inducing anaphylactic reactions by skin testing to be less than 0.02% and other studies have produced similar results.4-5 The rate of systemic reactions to skin testing is likely underscored. Thompson et. al reported a systemic reaction rate of 6% of patients receiving skin testing.6 It is important to recognize the risk of systemic reactions seeing skin testing is commonly done. It is also imperative to recognize the treatments for these reactions to prevent progression.
Hypothesis The systemic reaction rate to allergen immunotherapy and skin testing to aeroallergens is higher than previously reported. Biphasic anaphylactic reactions rarely occur with allergen immunotherapy and skin testing.
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Detailed Description
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Conditions
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Study Design
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RETROSPECTIVE
Study Groups
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CHART REVIEW ONLY
CHART REVIEW OF PATIENTS WITH SYSTEMIC REACTIONS
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
ALL
No
Sponsors
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University of South Florida
OTHER
Responsible Party
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UNIVERSITY OF SOUTH FLORIDA
Principal Investigators
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RICHARD F LOCKEY, MD
Role: PRINCIPAL_INVESTIGATOR
USF DIRECTOR OF ALLERGY AND IMMUNOLOGY
Locations
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USF
Tampa, Florida, United States
Countries
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References
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Bagg A, Chacko T, Lockey R. Reactions to prick and intradermal skin tests. Ann Allergy Asthma Immunol. 2009 May;102(5):400-2. doi: 10.1016/S1081-1206(10)60511-X.
Other Identifiers
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systemic reaction protocol
Identifier Type: -
Identifier Source: org_study_id
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