Microbial Community Composition and Dynamics in Lungs of Cystic Fibrosis Sibling Pairs

NCT ID: NCT00590330

Last Updated: 2011-05-13

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 55 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2007-10-31
• Study Completion Date: 2009-03-31

Brief Summary

The purpose of this study is to identify all the bacterial species present in the respiratory tracts of patients with Cystic Fibrosis (CF), and to connect them with clinical information. Traditional culture methods of throat swab and sputum samples can only identify the most prevalent bacteria in samples, those of which there are over about 5 million bacteria per teaspoon. A recently developed method has been found to be more sensitive and can detect up to several hundred bacterial species in throat swab or sputum sample of individual CF patients.

Detailed Description

This study does not include testing of any investigational drugs and this is a noninvasive study requiring only a sputum/swab sample paired with information contained in the routine clinic letters and laboratory results your CF physicians obtain at your regular clinic visits.

Conditions

Cystic Fibrosis

Study Design

• Observational Model Type: FAMILY_BASED
• Study Time Perspective: PROSPECTIVE

Eligibility Criteria

Inclusion Criteria

• Between the ages of 1-16 upon enrollment
• Diagnosis of Cystic Fibrosis

Exclusion Criteria

• None

• Minimum Eligible Age: 1 Year
• Maximum Eligible Age: 16 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Harvard University

OTHER

Sponsor Role: collaborator

Boston Children's Hospital

OTHER

Sponsor Role: lead

Responsible Party

Children's Hospital, Boston

Principal Investigators

Thomas Martin, MD

Role: PRINCIPAL_INVESTIGATOR

Boston Children's Hospital

Locations

Children's Hospital

Boston, Massachusetts, United States

Countries

United States

Other Identifiers

X07-10-0407

Identifier Type: -

Identifier Source: org_study_id