Closure of Perimembranous Ventricular Septal Defects With The AMPLATZER® Membranous VSD OCCLUDER

NCT ID: NCT00578708

Last Updated: 2019-02-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

35 participants

Study Classification

INTERVENTIONAL

Study Start Date

2003-09-30

Study Completion Date

2010-09-30

Brief Summary

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The purpose of this feasibility study is to investigate the safety of the AMPLATZER® Membranous VSD Occluder for the treatment of hemodynamically significant Perimembranous Ventricular Septal Defects.

Detailed Description

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Conditions

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Membranous Ventricular Septal Defects

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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1

Group Type EXPERIMENTAL

AMPLATZER Membranous VSD Occluder

Intervention Type DEVICE

Device closure with the AMPLATZER Membranous VSD Occluder

Interventions

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AMPLATZER Membranous VSD Occluder

Device closure with the AMPLATZER Membranous VSD Occluder

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Patients with hemodynamically significant Perimembranous ventricular septal defects

Exclusion Criteria

* Patients \< 8 kg
* Supracristal ventricular septal defects
* Left ventricle to right atrium shunting
* Prolapse of the aortic valve
* Right to left shunting through the defect
* Perimembranous VSD with an aneurysm and multiple shunts which can not be successfully closed with one device
* Patients with \<2mm aortic rim
* Sepsis (local/generalized)
* Complex heart lesions such as atrioventricular canal defect or Tetralogy of Fallot.
* Patients who are ASA intolerant
* Unable to be followed for the duration of the clinical trial
* Inability to obtain informed consent
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Abbott Medical Devices

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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University of Minnesota

Minneapolis, Minnesota, United States

Site Status

Washington University Medical Center

St Louis, Missouri, United States

Site Status

Children's Hospital UN/CU)

Omaha, Nebraska, United States

Site Status

Columbia University

New York, New York, United States

Site Status

Columbus Children's Hospital

Columbus, Ohio, United States

Site Status

Medical University of South Carolina

Charleston, South Carolina, United States

Site Status

Countries

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United States

Other Identifiers

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G020202

Identifier Type: -

Identifier Source: secondary_id

AGA-008

Identifier Type: -

Identifier Source: org_study_id

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