Early Lung Cancer Detection in Patients With Sputum Cytology and Autofluorescence Bronchoscopy in People at High Risk of Lung Cancer

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

400 participants

Study Classification

INTERVENTIONAL

Study Start Date

2002-11-30

Study Completion Date

2007-06-30

Brief Summary

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Lung cancer is the commonest malignant disease with a 5-year survival of 14%. In Hong Kong, it accounts for about 30% of all cancer death. The poor prognosis of lung cancer is due largely to the late clinical presentation of the disease. In order to improve the prognosis of lung cancer, an obvious approach is to develop sensitive methods for detecting lung cancer at much earlier stages when treatment is more likely to be curative.

However, the best way for identifying early lung cancer is still need to be determined. We hypothesis that by examining specimens that contain shed bronchial epithelial cells i.e. sputum, lung cancer can be sampled in its earliest possible phase. And by using autofluorescence bronchoscopy, a system specifically designed to detect early lung cancer/pre-invasive lesions, to identify the source of abnormal cells, we may able to detect eraly lung cancer and followed by curative treatment to improve the prognosis of this disease.

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Detailed Description

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Conditions

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Lung Neoplasms

Study Design

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Allocation Method

NON_RANDOMIZED

Primary Study Purpose

DIAGNOSTIC

Interventions

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Bronchoscopy

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Current or ex-smokers who have smoked at least 20-pack-years (e.g. 1 pack per day for 20 years or more)
* Informed consent

Exclusion Criteria

* Known malignant disease
* Unstable major medical disease
* Bleeding disorder
* Unwilling to have a bronchoscopy
* Women currently pregnant or nursing
* Known reaction to xylocaine, a local anaesthesia agent used for bronchoscopy

Minimum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No