Iron Supplementation of Marginally Low Birth Weight Infants
NCT ID: NCT00558454
Last Updated: 2020-03-26
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE4
380 participants
INTERVENTIONAL
2004-03-31
2014-11-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
QUADRUPLE
Study Groups
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1
Placebo
Iron
Ferrous succinate mixture
2
1 mg/kg/day from age 6 weeks to 6 months
Iron
Ferrous succinate mixture
3
2 mg/kg/day from age 6 weeks to 6 months
Iron
Ferrous succinate mixture
Interventions
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Iron
Ferrous succinate mixture
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Healthy at inclusion(6 weeks of age)
* No previous blood transfusion
* No previous iron supplementation
Exclusion Criteria
39 Days
45 Days
ALL
Yes
Sponsors
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The Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning (FORMAS)
OTHER_GOV
Jerring Foundation, Sweden
UNKNOWN
Oskar Foundation
OTHER
Umeå University
OTHER
Responsible Party
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Magnus Domellöf
MD, PhD
Principal Investigators
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Magnus Domellöf, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Umeå University, Sweden
Locations
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Karolinska Hospital (including Danderyd Hospital)
Stockholm, , Sweden
Umeå University Hospital
Umeå, , Sweden
Countries
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References
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Lindberg J, Norman M, Westrup B, Domellof M, Berglund SK. Lower systolic blood pressure at age 7 y in low-birth-weight children who received iron supplements in infancy: results from a randomized controlled trial. Am J Clin Nutr. 2017 Aug;106(2):475-480. doi: 10.3945/ajcn.116.150482. Epub 2017 Jun 28.
Lindberg J, Norman M, Westrup B, Ohrman T, Domellof M, Berglund SK. Overweight, Obesity, and Body Composition in 3.5- and 7-Year-Old Swedish Children Born with Marginally Low Birth Weight. J Pediatr. 2015 Dec;167(6):1246-52.e3. doi: 10.1016/j.jpeds.2015.08.045. Epub 2015 Sep 26.
Berglund SK, Westrup B, Domellof M. Iron supplementation until 6 months protects marginally low-birth-weight infants from iron deficiency during their first year of life. J Pediatr Gastroenterol Nutr. 2015 Mar;60(3):390-5. doi: 10.1097/MPG.0000000000000633.
Berglund SK, Lindberg J, Westrup B, Domellof M. Effects of iron supplements and perinatal factors on fetal hemoglobin disappearance in LBW infants. Pediatr Res. 2014 Nov;76(5):477-82. doi: 10.1038/pr.2014.116. Epub 2014 Aug 13.
Berglund SK, Westrup B, Hagglof B, Hernell O, Domellof M. Effects of iron supplementation of LBW infants on cognition and behavior at 3 years. Pediatrics. 2013 Jan;131(1):47-55. doi: 10.1542/peds.2012-0989. Epub 2012 Dec 10.
Berglund S, Lonnerdal B, Westrup B, Domellof M. Effects of iron supplementation on serum hepcidin and serum erythropoietin in low-birth-weight infants. Am J Clin Nutr. 2011 Dec;94(6):1553-61. doi: 10.3945/ajcn.111.013938. Epub 2011 Nov 9.
Berglund S, Westrup B, Domellof M. Iron supplements reduce the risk of iron deficiency anemia in marginally low birth weight infants. Pediatrics. 2010 Oct;126(4):e874-83. doi: 10.1542/peds.2009-3624. Epub 2010 Sep 6.
Other Identifiers
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Iron for LBW infants
Identifier Type: -
Identifier Source: org_study_id
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