Anxiety Disorders in Children - Association With Neurodevelopmental Delay/Disorder

NCT ID: NCT00553085

Last Updated: 2014-06-20

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 141 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2007-09-30
• Study Completion Date: 2014-03-31

Brief Summary

The main objective of the study is to examine the relationship between anxiety disorders and neurodevelopmental disorder/delay in children aged 7- 13 years.

Detailed Description

Project summary Anxiety disorders (AD's) in childhood are common and may cause great suffering.Childhood AD's may persist into adulthood and knowledge of important risk factors for development and maintenance of these disorders is essential.The development of AD's is due to a complex interaction between biological and environmental factors.This study will examine the relationship between AD's and two biological risk factors:1.Neurodevelopmental delays/disorders (NDD'S) in motor and cognitive function and 2.Temperament/personality.To date a few studies have consistently found that motor impairment is associated with childhood anxiety and predicts persistent anxiety in adolescence.The association between AD's and NDD's in cognitive functions such as language and attention is far less studied. In contrast, there is a huge research literature on temperament as a risk factor for AD's.The temperamental trait "behavioural inhibition" has been shown to be particularly associated with AD's.However, very few studies have examined the interplay between NDD's, temperament and anxiety.The study is a clinical case-control study of children aged 7-13 years with AD's referred to three different out-patient clinics.The participants will be assessed by diagnostic interviews, neuropsychological tests and temperament/personality instruments.Comparison groups are:1.children with ADHD (to compare AD's with another mental disorder related to NDD's) and 2.Non-referred children without a mental disorder. Follow-up at 6 months,1 and 5 years.A pilot study at two of the three out-patient clinics to be included,showed a sufficient sample size.Anticipated implications of the study include increased knowledge of biological risk factors and of latent neurological brain correlates,as well as treatment implications.Children with NDD's are often met with demands they cannot cope with due to their neurodevelopmental immaturity.To adjust the demands to the child's actual level of functioning is important.

Conditions

Anxiety Disorders

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

Anx group

No interventions assigned to this group

ADHD group

No interventions assigned to this group

Nonanx/nonadhd group

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• Clinical diagnosis of anxiety disorder or ADHD or no diagnosis

Exclusion Criteria

• Clinical diagnosis of PDD
• mental retardation
• children whose both parents do not speak Norwegian

• Minimum Eligible Age: 7 Years
• Maximum Eligible Age: 13 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

The Research Council of Norway

OTHER

Sponsor Role: collaborator

University Hospital, Akershus

OTHER

Sponsor Role: collaborator

Lovisenberg Diakonale Hospital

OTHER

Sponsor Role: collaborator

The Hospital for Sick Children

OTHER

Sponsor Role: collaborator

Regionsenter for barn og unges psykiske helse

OTHER

Sponsor Role: lead

Responsible Party

Hanne Kristensen

Director, Clinical Research Section

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Hanne Kristensen, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

Regionsenter for barn og unges psykiske helse

Locations

Akershus University Hospital

Lorenskog, Akershus, Norway

Lovisenberg Hospital

Oslo, Oslo County, Norway

Countries

Norway

Other Identifiers

181877/V50

Identifier Type: -

Identifier Source: secondary_id

1.2006.2943

Identifier Type: -

Identifier Source: org_study_id