Posterior Cingulate Function in Persons With Risk Factors for Alzheimer's Disease

NCT ID: NCT00478166

Last Updated: 2015-10-05

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 206 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2005-07-31
• Study Completion Date: 2007-10-31

Brief Summary

The purpose of this study is to use fMRI techniques to explore a certain part of the brain associated with Alzheimer's disease known as the posterior cingulate. Determining the functionality of this brain region may help us diagnose AD more accurately, thus allowing earlier treatment.

Detailed Description

The posterior cingulate is a key brain region suggested by recent studies to be affected in people at risk for Alzheimer's Disease (AD). Because the PC is affected very early in the course of AD and the region may have reduced function even prior to the onset of symptoms, further understanding of its functional role and its relationship to other brain regions may be helpful in detecting AD earlier and in monitoring disease progression and treatment. This project examines the role of the PC and its connections to other brain regions using functional magnetic resonance imaging (fMRI), a technique that allows us to examine the brain at work during tests of memory and decision-making. The main goal is to see if functional connections between brain regions are modulated by risk for AD.

Conditions

Magnetic Resonance Imaging; Alzheimer's Disease; Dementia; Adult Children; Risk

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: CROSS_SECTIONAL

Eligibility Criteria

Inclusion Criteria

• Cognitively healthy
• (Controls Only) Parents survived past age 70 and did/do not have memory problems.

Exclusion Criteria

• Claustrophobia
• Metallic or electronic implants

• Minimum Eligible Age: 55 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

VA Office of Research and Development

FED

Sponsor Role: collaborator

University of Wisconsin, Madison

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Sterling C Johnson, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Wisconsin/VA GRECC

Locations

University of Wisconsin - Wisconsin Comprehensive Memory Program

Madison, Wisconsin, United States

Countries

United States

Related Links

http://www.brainmap.wisc.edu

Johnson Imaging Lab website

Other Identifiers

2004-174

Identifier Type: -

Identifier Source: org_study_id