ESP Study: A Study to Assess the Effect of Adding Fuzeon (Enfuvirtide) to an Antiretroviral Regimen in Fuzeon-Naive Patients With Sustained HIV Viral Suppression.

NCT ID: NCT00461266

Last Updated: 2016-08-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Clinical Phase

PHASE4

Study Classification

INTERVENTIONAL

Study Start Date

2007-04-30

Study Completion Date

2008-01-31

Brief Summary

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This 2 arm study will assess the immunological benefits of adding Fuzeon to an antiretroviral regimen in HIV-infected, Fuzeon-naive patients with a CD4 cell count \<250 cells/mm3 and an HIV RNA viral load \<400 copies/mL. Eligible patients will be randomized to receive Fuzeon 90mg bid sc in addition to their current antiretroviral therapy, or to continue their current antiretroviral therapy alone. The anticipated time on study treatment is 3-12 months, and the target sample size is \<100 individuals.

Detailed Description

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Conditions

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HIV Infections

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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1

Group Type EXPERIMENTAL

enfuvirtide [Fuzeon]

Intervention Type DRUG

90mg sc bid

Antiretroviral therapy

Intervention Type DRUG

As prescribed

2

Group Type ACTIVE_COMPARATOR

Antiretroviral therapy

Intervention Type DRUG

As prescribed

Interventions

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enfuvirtide [Fuzeon]

90mg sc bid

Intervention Type DRUG

Antiretroviral therapy

As prescribed

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* adult patients, \>=18 years of age;
* documented chronic HIV infection;
* currently receiving a stable antiretroviral regimen;
* CD4 cell count \<250 cells/mm3;
* HIV RNA viral load \<400 copies/mL for \>12 months.

Exclusion Criteria

* prior exposure to Fuzeon;
* prior non-adherence to antiretroviral treatment regimens;
* active opportunistic infection;
* currently taking, or anticipated to take during the study, any immunomodulator.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hoffmann-La Roche

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Clinical Trials

Role: STUDY_DIRECTOR

Hoffmann-La Roche

Locations

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Carlton, , Australia

Site Status

Darlinghurst, , Australia

Site Status

Melbourne, , Australia

Site Status

Miami, , Australia

Site Status

Perth, , Australia

Site Status

South Yarra, , Australia

Site Status

Sydney, , Australia

Site Status

Countries

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Australia

Other Identifiers

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ML19355

Identifier Type: -

Identifier Source: org_study_id

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