BOSS Study: A Study of Fuzeon Using the Needle-Free Biojector 2000 in Patients With HIV-1 Infection

NCT ID: NCT00337701

Last Updated: 2015-11-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

326 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-06-30

Study Completion Date

2007-01-31

Brief Summary

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This study will evaluate the signs and symptoms associated with Fuzeon injection (90mg sc) using the B2000 needle-free injection device, in HIV-1 positive patients experienced to Fuzeon treatment, but having difficulty tolerating long-term (\>4 weeks) administration of Fuzeon with the standard needle and syringe. Patients will be randomized to the B2000 device or the standard needle and syringe for 4 weeks; all patients will use the B2000 device for the next 4 weeks. The anticipated time on study treatment is \<3 months, and the target sample size is 100-500 individuals.

Detailed Description

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Conditions

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HIV Infections

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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1

Group Type EXPERIMENTAL

enfuvirtide [Fuzeon]

Intervention Type DRUG

90mg sc bid by Biojector 2000 NFID for 8 weeks

2

Group Type EXPERIMENTAL

enfuvirtide [Fuzeon]

Intervention Type DRUG

90mg sc bid by standard needle and syringe for 4 weeks, followed by 90mg sc bid by Biojector 2000 NFID for 4 weeks.

Interventions

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enfuvirtide [Fuzeon]

90mg sc bid by Biojector 2000 NFID for 8 weeks

Intervention Type DRUG

enfuvirtide [Fuzeon]

90mg sc bid by standard needle and syringe for 4 weeks, followed by 90mg sc bid by Biojector 2000 NFID for 4 weeks.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* adult patients \>=16 years of age;
* current or former Fuzeon user who may benefit from needle-free administration of Fuzeon;
* naive to use of the B2000 device;
* positive test results for human immunodeficiency virus infection.

Exclusion Criteria

* patients naive to Fuzeon;
* inability to self-inject Fuzeon, or no reliable caregiver to administer injections;
* evidence of active, untreated, opportunistic infections.
Minimum Eligible Age

16 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Trimeris

INDUSTRY

Sponsor Role collaborator

Hoffmann-La Roche

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Clinical Trials

Role: STUDY_DIRECTOR

Hoffmann-La Roche

Locations

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Birmingham, Alabama, United States

Site Status

Phoenix, Arizona, United States

Site Status

Phoenix, Arizona, United States

Site Status

Fountain Valley, California, United States

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Hayward, California, United States

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Long Beach, California, United States

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Los Angeles, California, United States

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Palm Springs, California, United States

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San Francisco, California, United States

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Santa Clara, California, United States

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Denver, Colorado, United States

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Fort Lauderdale, Florida, United States

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Fort Myers, Florida, United States

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North Miami Beach, Florida, United States

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Orlando, Florida, United States

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Plantation, Florida, United States

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Port Saint Lucie, Florida, United States

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Tampa, Florida, United States

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Atlanta, Georgia, United States

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Decatur, Georgia, United States

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Boise, Idaho, United States

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Chicago, Illinois, United States

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Baltimore, Maryland, United States

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Silver Spring, Maryland, United States

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Boston, Massachusetts, United States

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Berkley, Michigan, United States

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St Louis, Missouri, United States

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St Louis, Missouri, United States

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Somers Point, New Jersey, United States

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Voorhees Township, New Jersey, United States

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New York, New York, United States

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New York, New York, United States

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Rochester, New York, United States

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Winston-Salem, North Carolina, United States

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Portland, Oregon, United States

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Philadelphia, Pennsylvania, United States

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Fort Worth, Texas, United States

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Galveston, Texas, United States

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Houston, Texas, United States

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Houston, Texas, United States

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Hampton, Virginia, United States

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Spokane, Washington, United States

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Ponce, , Puerto Rico

Site Status

Santurce, , Puerto Rico

Site Status

Countries

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United States Puerto Rico

Other Identifiers

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ML19849

Identifier Type: -

Identifier Source: org_study_id

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