Integrated Treatment to Persons With Mental Disorders and Co-occurring Substance Use Disorders

NCT ID: NCT00447733

Last Updated: 2012-03-26

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 76 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2007-03-31
• Study Completion Date: 2010-12-31

Brief Summary

The purpose of this study is to determine whether Integrated Treatment is effective in the treatment of anxiety and/or depression with co-occurring substance use disorders.

Detailed Description

Patients with mental disorders and co-occuring substance use disorders are characterized by high suicide rates, high treatment drop-out rates and long-lasting interpersonal, work, school, health and legal problems. Because mental disorders and substance use disorders co-exist and interact, it may be important to provide a treatment that addresses the substance misuse and mental health problems in an integrated and comprehensive way. Additionally, the health services for patients with mental health and substance use disorders are usually provided by different services and health professionals that rarely cooperate or have qualifications on both kinds of disorders. This also calls for an integration of the services on an organizational level. This approach of integrating services and treatment approaches for both diseases in a comprehensive way is called Integrated Treatment. Several studies have shown that Integrated Treatment is effective in treating the comorbidity of severe mental illness and substance use disorders. The over-all aim of this study is to evaluate the effects of evidence-based Integrated Treatment in anxiety and/or depression with co-occurring substance use disorders. The effects of the treatment will be assesses on changes in substance use and psychopathology.

Comparison: patients receiving treatment-as-usual or non-manualized treatment at general mental health outpatients clinics.

Conditions

Anxiety Disorders; Mood Disorders; Substance Use Disorders

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Integrated treatment

Evidence-based psychosocial and pharmacological treatment of both the substance use disorder and the mental health disorder is provided at the same time and by the same therapists in a comprehensive way.

Group Type: EXPERIMENTAL

Integrated mental health and substance use treatment

Intervention Type: BEHAVIORAL

Psychosocial and drug treatment targeting both the substance use disorder and the psychiatric disorder in an integrated and comprehensive way.

Treatment as usual

Non-manualized clinic-based treatment provided by therapists without formal training in integrated treatment of co-occurring disorders.

Group Type: ACTIVE_COMPARATOR

Treatment as usual

Intervention Type: BEHAVIORAL

Non-standardized psychiatric outpatient treatment

Interventions

Integrated mental health and substance use treatment

Psychosocial and drug treatment targeting both the substance use disorder and the psychiatric disorder in an integrated and comprehensive way.

Intervention Type: BEHAVIORAL

Treatment as usual

Non-standardized psychiatric outpatient treatment

Intervention Type: BEHAVIORAL

Other Intervention Names

dual disorder treatment; co-occurring disorders; TAU; non-manualized

Eligibility Criteria

Inclusion Criteria

• clinical diagnosis of substance use disorder
• clinical diagnosis of anxiety disorders
• clinical diagnosis of nonpsychotic mood disorders
• written consent
• planning to live in the catchment area during the treatment

Exclusion Criteria

• schizophrenia spectrum disorders
• other psychotic disorders
• mental retardation
• nicotine abuse/dependency only
• prescription drug abuse/dependency only
• planning to move out of the catchment area during the study
• not able to read or write Norwegian

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

SINTEF Health Research

OTHER

Sponsor Role: collaborator

University of Oslo

OTHER

Sponsor Role: lead

Responsible Party

Rolf W. Grawe

Ph.d.; Assistent Professor; University of Oslo

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Rolf W. Gråwe, Ph.D

Role: PRINCIPAL_INVESTIGATOR

Alcohol and Drug Treatment Health Trust in Central Norway; Norwegian Centre of Addiction Research, University of Oslo

References

Wusthoff LE, Waal H, Grawe RW. The effectiveness of integrated treatment in patients with substance use disorders co-occurring with anxiety and/or depression--a group randomized trial. BMC Psychiatry. 2014 Mar 5;14:67. doi: 10.1186/1471-244X-14-67.

Reference Type: DERIVED

PMID: 24597469 (View on PubMed)

Wusthoff LE, Waal H, Grawe RW. When research meets reality-lessons learned from a pragmatic multisite group-randomized clinical trial on psychosocial interventions in the psychiatric and addiction field. Subst Abuse. 2012;6:95-106. doi: 10.4137/SART.S9245. Epub 2012 Aug 16.

Reference Type: DERIVED

PMID: 22933843 (View on PubMed)

Other Identifiers

NFR175394/V50

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

78i068

Identifier Type: -

Identifier Source: org_study_id