Genetic Analysis of Thyrotoxic Periodic Paralysis

NCT ID: NCT00443833

Last Updated: 2007-03-06

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 80 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2004-01-31
• Study Completion Date: 2005-12-31

Brief Summary

Thyrotoxic periodic paralysis (TPP) is characterized by episodes of reversible hypokalemia and weakness in thyrotoxic patients. It is commonly found in males of Asian descent and is also seen in individuals having Native American or Hispanic ancestry. Therefore genetic etiology has been hypothesized. This study, we aim to find the susceptibility genes that associate with TPP. Both candidate genes approach and genome wide association study have been conducted.

Detailed Description

This study is a genetic association study. It included 50 cases of TPP patients and 80 cases of male, hyperthyroid patients who didn't have hypokalemia as a well characterized controls. After informed consent were obtained, genomic DNA from leukocyte were extracted. Pooled DNA were constructed and whole genome scan using 10K GeneChip microarray were genotyped on pooled genomic DNA.

Conditions

Thyrotoxic Periodic Paralysis

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: OTHER

Eligibility Criteria

Inclusion Criteria

TPP

• Hyperthyroid patients from any causes
• Evidence of hypokalemia (k<3.5 mg/dl)from intracellular shift (Urine K<15 mg/dl, TTKG<2)
• Episodic paralysis

Exclusion Criteria

• Hypokalemia from GI or renal loss

• Minimum Eligible Age: 15 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: No

Sponsors

Ramathibodi Hospital

OTHER

Sponsor Role: lead

Principal Investigators

Wallaya Jongjaroenprasert, MD

Role: PRINCIPAL_INVESTIGATOR

Endocrinology Unit, Ramathibodi Hospital, Mahidol University

Other Identifiers

11-46-21

Identifier Type: -

Identifier Source: org_study_id