Therapeutic Plasma Exchange in Thyrotoxicosis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

27 participants

Study Classification

OBSERVATIONAL

Study Start Date

1999-01-01

Study Completion Date

2020-04-01

Brief Summary

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Therapeutic plasma exchange (TPE) is indicated in cases where antithyroid medications cannot be used due to the side effects or attain no adequate hormonal suppression response at the highest dosage and in cases of rapid onset of clinical symptoms. This study presents the treatment results of patients who underwent TPE and subsequently operated for thyrotoxicosis.

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Detailed Description

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Background: Therapeutic plasma exchange (TPE) is indicated in cases where antithyroid medications cannot be used due to the side effects or attain no adequate hormonal suppression response at the highest dosage and in cases of rapid onset of clinical symptoms. This study presents the treatment results of patients who underwent TPE and subsequently operated for thyrotoxicosis.

Methods: The files of 27 patients who underwent preoperative TPE for thyrotoxicosis between January 1999 and February 2019 were retrospectively analyzed. The demographic and clinical features of the patients were included.

Conditions

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Thyrotoxicosis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Interventions

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Therapeutic plasma exchange

Therapeutic plasma exchange filtrates plasma and decreases thyroid hormone concentration in the blood

Intervention Type DEVICE

Other Intervention Names

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Thyroidectomy

Eligibility Criteria

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Inclusion Criteria

* thyrotoxicosis unresponsive to medication
* adverse reaction to the medications
* need for rapid treatment in patients that need urgent surgery

Exclusion Criteria

* The patients who did not undergo surgery post-therapeutic plasma exchange
* Preoperative hypocalcemia,
* hemodynamically unstable patients
* patients not suitable for central catheter placement

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No