A Multicentre Trial to Determine the Efficacy and Safety of Milnacipran in the Treatment of Fibromyalgia Syndrome

NCT ID: NCT00436033

Last Updated: 2013-07-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

1429 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-02-28

Study Completion Date

2007-09-30

Brief Summary

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Investigation of efficacy and safety of treatment with milnacipran in the treatment of fibromyalgia syndrome.

Detailed Description

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Conditions

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Fibromyalgia Syndrome

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Placebo

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Minalcipran

Group Type EXPERIMENTAL

milnacipran

Intervention Type DRUG

Interventions

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milnacipran

Intervention Type DRUG

Placebo

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* patient with a diagnosis of fibromyalgia according to the 1990 American College of Rheumatology (ACR) criteria

Exclusion Criteria

* psychiatric illness
* depression of generalised anxiety disorder
* suicidal risk
* substance abuse
* active cardiac disease
* pulmonary dysfunction
* liver disease
* renal impairment
* autoimmune disease
* chronic inflammatory rheumatoid disease
* current systemic infection
* epileptic
* active cancer
* sleep apnea
* active peptic ulcer
* inflammatory bowel disease
* unstable endocrine disease
* for men : prostatic enlargement of genito-urinary disorders
* for women : pregnancy or breast feeding
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Pierre Fabre Medicament

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Dr Jaime C BRANCO

Role: PRINCIPAL_INVESTIGATOR

HOSPITAL EGAS MONIZ

Locations

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Rheumatology Ambulance

Pardubice, , Czechia

Site Status

FREDERIKSBERG HOSPITAL - Clinic of Rheumatology

Frederiksberg, , Denmark

Site Status

Kuopion Oma Laakari Oy

Kuopio, , Finland

Site Status

Hopital Hotel Dieu

Paris, , France

Site Status

KKSK KLINIKUM DER UNIVERSITAET ZU KOELN - Anaesthesiology and Intensive Care

Cologne, , Germany

Site Status

Ospedale Luigi Sacco

Milan, , Italy

Site Status

Center For Clinical Studies

Lillehamer, , Norway

Site Status

"Nasz Lekarz"

Torun, , Poland

Site Status

Hospital Egas Moniz

Lisbon, , Portugal

Site Status

Dr I CANTACUZINO CLINICAL HOSPITAL

Bucharest, , Romania

Site Status

Hospital de La Esperanza

Barcelona, , Spain

Site Status

Gottfriesclinic Ab

Mölndal, , Sweden

Site Status

KINGS COLLEGE HOSPITAL - Clinic Trial Unit Academic Department of Rheumatology

London, , United Kingdom

Site Status

Countries

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Czechia Denmark Finland France Germany Italy Norway Poland Portugal Romania Spain Sweden United Kingdom

References

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Branco JC, Zachrisson O, Perrot S, Mainguy Y; Multinational Coordinator Study Group. A European multicenter randomized double-blind placebo-controlled monotherapy clinical trial of milnacipran in treatment of fibromyalgia. J Rheumatol. 2010 Apr;37(4):851-9. doi: 10.3899/jrheum.090884. Epub 2010 Feb 15.

Reference Type DERIVED
PMID: 20156949 (View on PubMed)

Other Identifiers

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F02207GE302

Identifier Type: -

Identifier Source: org_study_id

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