Socioeconomic Status, Psychosocial Factors, and CVD Risk in Mexican-American Women

NCT ID: NCT00387166

Last Updated: 2012-01-06

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 304 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2006-10-31
• Study Completion Date: 2010-06-30

Brief Summary

Cardiovascular disease (CVD) is the leading cause of death in American women, claiming on average 40% of all female deaths each year. Although the number of CVD-related deaths in the United States has decreased over the last several decades, the rate of decline has been less for women than for men. Specifically, minority women of low socioeconomic status make up a disproportionately high number of CVD cases and related deaths. Previous studies suggest that, in addition to many other variables, psychosocial variables may contribute to ethnic CVD disparities. More research, however, is needed to help understand and reduce these differences. This study will examine the associations among socioeconomic status, psychological and social factors, CVD biomarkers, and CVD in Mexican-American women.

Detailed Description

One in four women in the United States has some form of CVD, which includes heart disease, high blood pressure, and heart attack. Minority and low socioeconomic status populations show particularly disproportionate rates of CVD morbidity and mortality. Previous research suggests that individuals with lower social status may suffer negative emotional and physical health consequences due to increased stress experienced across multiple areas of life. It is believed that stress may directly affect behavioral, physiological, and emotional risk processes, which have all been linked to increased CVD risk. In addition, people with low socioeconomic status are often less capable of seeking psychosocial resources with which to manage stress, making them especially vulnerable to the associated physical and emotional wear and tear. More information is needed on the effects of psychosocial variables on the cardiovascular health of minority, specifically Mexican-American, women. This study will examine the associations among socioeconomic status, psychological and social factors, CVD biomarkers, and CVD in Mexican-American women.

Participation in this study will involve two home visits, with total participation time lasting about 6 hours. During the first study visit, participants will complete a variety of questionnaires on stressful experiences, social relationships, background and culture, thoughts and emotions, health habits, and medical history. Participants will also have their blood pressure measured and will be given a container and instructions to perform a 12-hour overnight urine collection.

During the second study visit, occurring a couple of days after the first visit, participants will undergo a blood draw, physical and vital sign measurements, and a training session on how to use an ambulatory blood pressure monitor and handheld computer diary. Participants who fit properly into the arm cuff of the ambulatory blood pressure monitor will then be asked to wear the monitor for 36 hours. Every time the monitor records a blood pressure reading, participants will be asked to use their handheld computer diary and answer questions about temperature, exercise, posture, stress, mood, and social interactions. There will be a total of 52 to 56 diary entries, taking between 2 and 3 minutes to complete each entry. Within 1 month, participants will receive a letter summarizing their health profile in terms of weight, cholesterol levels, and blood glucose. Participants will also be provided with information on seeking appropriate treatments for any health problems discovered on their profile.

Conditions

Hypertension; Cardiovascular Disease; Metabolic Disorders

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

1

Mexican-American women, aged 40-65

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• Self identifies as Mexican-American
• Resides in Chula Vista or National City
• Sufficiently mobile to complete ambulatory blood pressure assessment

Exclusion Criteria

• Pregnant
• Current or historical cardiovascular disease
• Current Type II diabetes
• Cancer treatment in the 10 years before study entry
• Bleeding disorder
• Use of medications with autonomic effects

• Minimum Eligible Age: 40 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: Yes

Sponsors

National Heart, Lung, and Blood Institute (NHLBI)

NIH

Sponsor Role: collaborator

San Diego State University

OTHER

Sponsor Role: lead

Responsible Party

Linda C. Gallo

Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Linda C. Gallo, PhD

Role: PRINCIPAL_INVESTIGATOR

San Diego State University

John Elder, PhD

Role: PRINCIPAL_INVESTIGATOR

San Diego State University

Paul Mills, PhD

Role: PRINCIPAL_INVESTIGATOR

University of California, San Diego

Locations

San Diego State University, Institute for Behavioral and Community Health

San Diego, California, United States

Countries

United States

References

Gallo LC, Matthews KA. Understanding the association between socioeconomic status and physical health: do negative emotions play a role? Psychol Bull. 2003 Jan;129(1):10-51. doi: 10.1037/0033-2909.129.1.10.

Reference Type: BACKGROUND

PMID: 12555793 (View on PubMed)

Matthews KA, Gallo LC. Psychological perspectives on pathways linking socioeconomic status and physical health. Annu Rev Psychol. 2011;62:501-30. doi: 10.1146/annurev.psych.031809.130711.

Reference Type: BACKGROUND

PMID: 20636127 (View on PubMed)

Gallo LC, Penedo FJ, Espinosa de los Monteros K, Arguelles W. Resiliency in the face of disadvantage: do Hispanic cultural characteristics protect health outcomes? J Pers. 2009 Dec;77(6):1707-46. doi: 10.1111/j.1467-6494.2009.00598.x. Epub 2009 Sep 30.

Reference Type: BACKGROUND

PMID: 19796063 (View on PubMed)

Gallo LC, Fortmann AL, Roesch SC, Barrett-Connor E, Elder JP, de los Monteros KE, Shivpuri S, Mills PJ, Talavera GA, Matthews KA. Socioeconomic status, psychosocial resources and risk, and cardiometabolic risk in Mexican-American women. Health Psychol. 2012 May;31(3):334-42. doi: 10.1037/a0025689. Epub 2011 Nov 7.

Reference Type: RESULT

PMID: 22059620 (View on PubMed)

Gallo LC, Jimenez JA, Shivpuri S, Espinosa de los Monteros K, Mills PJ. Domains of chronic stress, lifestyle factors, and allostatic load in middle-aged Mexican-American women. Ann Behav Med. 2011 Feb;41(1):21-31. doi: 10.1007/s12160-010-9233-1.

Reference Type: RESULT

PMID: 20878511 (View on PubMed)

Gonzalez P, Castaneda SF, Mills PJ, Talavera GA, Elder JP, Gallo LC. Determinants of breast, cervical and colorectal cancer screening adherence in Mexican-American women. J Community Health. 2012 Apr;37(2):421-33. doi: 10.1007/s10900-011-9459-2.

Reference Type: RESULT

PMID: 21874364 (View on PubMed)

Shivpuri S, Gallo LC, Mills PJ, Matthews KA, Elder JP, Talavera GA. Trait anger, cynical hostility and inflammation in Latinas: variations by anger type? Brain Behav Immun. 2011 Aug;25(6):1256-63. doi: 10.1016/j.bbi.2011.04.016. Epub 2011 May 1.

Reference Type: RESULT

PMID: 21554946 (View on PubMed)

Gallo LC, Fortmann AL, de Los Monteros KE, Mills PJ, Barrett-Connor E, Roesch SC, Matthews KA. Individual and neighborhood socioeconomic status and inflammation in Mexican American women: what is the role of obesity? Psychosom Med. 2012 Jun;74(5):535-42. doi: 10.1097/PSY.0b013e31824f5f6d. Epub 2012 May 11.

Reference Type: DERIVED

PMID: 22582313 (View on PubMed)

Related Links

http://www.ibachsd.org/

More information at the Institute for Behavioral and Community Health (IBACH) Webpage

Other Identifiers

R01HL081604-01A1

Identifier Type: NIH

Identifier Source: secondary_id

View Link

G00006532

Identifier Type: -

Identifier Source: secondary_id

1339

Identifier Type: -

Identifier Source: org_study_id