A Study Evaluating the Safety and Clinical Activity of HCV-796 in Treatment-Naive and Non-Responder Subjects

NCT ID: NCT00367887

Last Updated: 2013-02-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

246 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-10-31

Study Completion Date

2008-07-31

Brief Summary

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This is a phase 2, randomized, open-label study comparing the safety, antiviral activity, and pharmacokinetics of HCV-796 administered in combination with peginterferon alfa 2B (Peg-Intron) plus concomitant Rebetol vs. Peg-Intron plus Rebetol in Hepatitis C Virus (HCV) genotype

1-infected subjects who are either naive to treatment or who have previously failed treatment (non-responders).

Detailed Description

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Conditions

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Hepatitis C

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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1

Group Type ACTIVE_COMPARATOR

Peg-Intron

Intervention Type DRUG

SC injection, weight based dosing, weekly, 48 weeks

REBETOL

Intervention Type DRUG

Capsules, weight based dosing, Q12 hrs daily, 48weeks

2

Group Type ACTIVE_COMPARATOR

HCV 796

Intervention Type DRUG

Capsules, 500 mg, Q 12 hrs. daily, 48 weeks

Peg-Intron

Intervention Type DRUG

SC injection, weight based dosing, weekly, 48 weeks

REBETOL

Intervention Type DRUG

Capsules, weight based dosing, Q12 hrs daily, 48weeks

3

Group Type ACTIVE_COMPARATOR

HCV 796

Intervention Type DRUG

Capsules, 500 mg, Q 12 hrs. daily, 48 weeks

Peg-Intron

Intervention Type DRUG

SC injection, weight based dosing, weekly, 48 weeks

REBETOL

Intervention Type DRUG

Capsules, weight based dosing, Q12 hrs daily, 48weeks

Interventions

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Peg-Intron

SC injection, weight based dosing, weekly, 48 weeks

Intervention Type DRUG

REBETOL

Capsules, weight based dosing, Q12 hrs daily, 48weeks

Intervention Type DRUG

HCV 796

Capsules, 500 mg, Q 12 hrs. daily, 48 weeks

Intervention Type DRUG

Peg-Intron

SC injection, weight based dosing, weekly, 48 weeks

Intervention Type DRUG

REBETOL

Capsules, weight based dosing, Q12 hrs daily, 48weeks

Intervention Type DRUG

HCV 796

Capsules, 500 mg, Q 12 hrs. daily, 48 weeks

Intervention Type DRUG

Peg-Intron

SC injection, weight based dosing, weekly, 48 weeks

Intervention Type DRUG

REBETOL

Capsules, weight based dosing, Q12 hrs daily, 48weeks

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Infection with HCV genotype 1.
* HCV- infected subjects naive to treatment.
* HCV-infected non-responder subjects.

Exclusion Criteria

* Women who are pregnant or breastfeeding.
* ALT \>/ or = 5X the upper limit of normal.
* AST \>/ or = 5X the upper limit of normal.
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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ViroPharma

INDUSTRY

Sponsor Role collaborator

Wyeth is now a wholly owned subsidiary of Pfizer

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Pfizer CT.gov Call Center

Role: STUDY_DIRECTOR

Pfizer

Locations

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Pfizer Investigational Site

Anaheim, California, United States

Site Status

Pfizer Investigational Site

La Jolla, California, United States

Site Status

Pfizer Investigational Site

La Jolla, California, United States

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Pfizer Investigational Site

Los Angeles, California, United States

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Pfizer Investigational Site

Pasadena, California, United States

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San Diego, California, United States

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San Diego, California, United States

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Pfizer Investigational Site

San Francisco, California, United States

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San Francisco, California, United States

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Washington D.C., District of Columbia, United States

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Pfizer Investigational Site

Gainesville, Florida, United States

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Miami, Florida, United States

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Atlanta, Georgia, United States

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Louisville, Kentucky, United States

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Boston, Massachusetts, United States

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Worcester, Massachusetts, United States

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Detroit, Michigan, United States

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Plymouth, Minnesota, United States

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Saint Paul, Minnesota, United States

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St Louis, Missouri, United States

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Albuquerque, New Mexico, United States

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New York, New York, United States

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New York, New York, United States

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Pfizer Investigational Site

The Bronx, New York, United States

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The Bronx, New York, United States

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Pfizer Investigational Site

Chapel Hill, North Carolina, United States

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Durham, North Carolina, United States

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Cincinnati, Ohio, United States

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Cleveland, Ohio, United States

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Philadelphia, Pennsylvania, United States

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Houston, Texas, United States

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Annandale, Virginia, United States

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Pfizer Investigational Site

Fairfax, Virginia, United States

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Pfizer Investigational Site

Richmond, Virginia, United States

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Pfizer Investigational Site

Santurce, , Puerto Rico

Site Status

Countries

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United States Puerto Rico

Related Links

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Other Identifiers

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B3381001

Identifier Type: -

Identifier Source: secondary_id

3173A1-200

Identifier Type: -

Identifier Source: org_study_id

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