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Relationship of Genes and Life Events to Blood Pressure

NCT ID: NCT00327431

Last Updated: 2008-05-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

120 participants

Study Classification

OBSERVATIONAL

Study Start Date

2006-11-30

Study Completion Date

2007-12-31

Brief Summary

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Research suggests that blood pressure is influenced by both genetic and environmental factors. The goal of this study is to find genes that play a role in blood pressure and understand how they interact with life events (such as job stress) to influence blood pressure. We hypothesize that the gene for endothelin-1 is associated with increased blood pressure. Further, we predict that this genetic relationship is moderated by psychosocial stress factors, specifically job strain and marital cohesion.

Detailed Description

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Conditions

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Hypertension Psychosocial Factors

Keywords

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Hypertension Blood Pressure Psychosocial Factors

Study Design

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Study Time Perspective

PROSPECTIVE

Interventions

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Cheek swab samples for DNA

Intervention Type GENETIC

Eligibility Criteria

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Inclusion Criteria

* Previous participation in a study of psychosocial stressors and blood pressure (Double Exposure Study) and agreement to participate in follow-up studies

Exclusion Criteria

* Withdrawal of consent
Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Sunnybrook Health Sciences Centre

OTHER

Sponsor Role lead

Principal Investigators

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Brian Baker, MB, ChB

Role: STUDY_CHAIR

University of Toronto

Sheldon Tobe, MD

Role: STUDY_CHAIR

Sunnybrook Health Sciences Centre

Locations

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Sunnybrook Health Sciences Centre

Toronto, Ontario, Canada

Site Status

Countries

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Canada

References

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Tobe SW, Kiss A, Szalai JP, Perkins N, Tsigoulis M, Baker B. Impact of job and marital strain on ambulatory blood pressure results from the double exposure study. Am J Hypertens. 2005 Aug;18(8):1046-51. doi: 10.1016/j.amjhyper.2005.03.734.

Reference Type BACKGROUND
PMID: 16109318 (View on PubMed)

Other Identifiers

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1000009109

Identifier Type: -

Identifier Source: org_study_id