Age of Red Blood Cells in Premature Infants Study (ARIPI)
NCT ID: NCT00326924
Last Updated: 2018-01-19
Study Results
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View full resultsBasic Information
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COMPLETED
NA
377 participants
INTERVENTIONAL
2006-05-31
2012-06-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
QUADRUPLE
Study Groups
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Biological
PRBCs that are less than 7 days old are considered 'fresh'.
Transfusion
PRBC blood transfusions.
Standard PRBCs
PRBCs 'stored' as per hospital policy.
Transfusion
PRBC blood transfusions.
Interventions
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Transfusion
PRBC blood transfusions.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* admitted to participating NICU
* consent acquired from proxy for the patient
Exclusion Criteria
* requirement for an exchange transfusion
* will be receiving directed donations
* have rare blood types/difficult cross-match
* proxy has refused consent
* moribund on admission to NICU/expected to die
* mitigating child protection issues
1 Minute
37 Weeks
ALL
No
Sponsors
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Ottawa Hospital Research Institute
OTHER
Responsible Party
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Principal Investigators
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Dean Fergusson, PhD
Role: STUDY_DIRECTOR
OHRI
Locations
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Ottawa Hospital
Ottawa, Ontario, Canada
Countries
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References
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Kekre N, Mallick R, Allan D, Tinmouth A, Tay J. The impact of prolonged storage of red blood cells on cancer survival. PLoS One. 2013 Jul 16;8(7):e68820. doi: 10.1371/journal.pone.0068820. Print 2013.
Fergusson DA, Hebert P, Hogan DL, LeBel L, Rouvinez-Bouali N, Smyth JA, Sankaran K, Tinmouth A, Blajchman MA, Kovacs L, Lachance C, Lee S, Walker CR, Hutton B, Ducharme R, Balchin K, Ramsay T, Ford JC, Kakadekar A, Ramesh K, Shapiro S. Effect of fresh red blood cell transfusions on clinical outcomes in premature, very low-birth-weight infants: the ARIPI randomized trial. JAMA. 2012 Oct 10;308(14):1443-51. doi: 10.1001/2012.jama.11953.
Fergusson D, Hutton B, Hogan DL, LeBel L, Blajchman MA, Ford JC, Hebert P, Kakadekar A, Kovacs L, Lee S, Sankaran K, Shapiro S, Smyth JA, Ramesh K, Bouali NR, Tinmouth A, Walker R. The age of red blood cells in premature infants (ARIPI) randomized controlled trial: study design. Transfus Med Rev. 2009 Jan;23(1):55-61. doi: 10.1016/j.tmrv.2008.09.005.
Other Identifiers
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2004706-01H
Identifier Type: -
Identifier Source: org_study_id
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