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Angiotensin-Converting Enzyme Polymorphism and Acute Renal Failure (ECAREA)

NCT ID: NCT00316576

Last Updated: 2008-01-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Total Enrollment

160 participants

Study Classification

OBSERVATIONAL

Study Start Date

2006-05-31

Study Completion Date

2006-11-30

Brief Summary

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Associations between angiotensin-converting enzyme gene polymorphism and occurrence and outcome of ARDS, and with respiratory complications post cardiopulmonary bypass have already been demonstrated. Based on physiological effects of angiotensin II, we hypothesized that the I allele of the angiotensin-converting enzyme Insertion/Deletion polymorphism may be associated with a higher risk of acute renal failure in critically ill patients.

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Detailed Description

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Associations between angiotensin-converting enzyme gene polymorphism and occurrence and outcome of ARDS, and with respiratory complications post cardiopulmonary bypass have already been demonstrated. Based on physiological effects of angiotensin II, we hypothesized that the I allele of the angiotensin-converting enzyme Insertion/Deletion polymorphism may be associated with a higher risk of acute renal failure in critically ill patients.

Conditions

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Kidney Failure, Acute Critical Illness

Study Design

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Study Time Perspective

PROSPECTIVE

Interventions

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Blood sampling for PCR

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Age \> 18 yrs
* ICU stay \> 48 hours

Exclusion Criteria

* Age \< 18 yrs
* Creatinine \> 180 µmol/L
* Absence of consent
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Caen

OTHER

Sponsor Role lead

Principal Investigators

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Damien du Cheyron, MD

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Caen

Locations

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Medical Intensive care Unit; Caen University Hospital

Caen, , France

Site Status

Countries

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France

References

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du Cheyron D, Fradin S, Ramakers M, Terzi N, Guillotin D, Bouchet B, Daubin C, Charbonneau P. Angiotensin converting enzyme insertion/deletion genetic polymorphism: its impact on renal function in critically ill patients. Crit Care Med. 2008 Dec;36(12):3178-83. doi: 10.1097/CCM.0b013e318186a299.

Reference Type DERIVED
PMID: 19020433 (View on PubMed)

Other Identifiers

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05-130

Identifier Type: -

Identifier Source: org_study_id

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