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Effect of Folic Acid Treatment in Coronary Artery Disease

NCT ID: NCT00300352

Last Updated: 2008-08-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE2

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2004-05-31

Brief Summary

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We seek to examine the effects of folic acid treatment on vascular function in patients with coronary artery disease. Our hypothesis is that folic acid treatment will improve vascular function

Detailed Description

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Common vascular disease states including diabetes and atherosclerosis are associated with endothelial dysfunction, characterised by reduced bioactivity of nitric oxide (NO). Folates are thought to improve endothelial function,but the mechanism by which this effect occurs is poorly understood. We propose to study the effects of folate supplementation on endothelial function in patients with coronary artery disease.

Conditions

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Coronary Artery Disease

Keywords

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Coronary artery disease Folic acid Endothelial function

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Interventions

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Folic Acid

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

Clinical diagnosis of coronary artery disease

Exclusion Criteria

Recent acute coronary event Renal and/or hepatic dysfunction Metallic implants
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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British Heart Foundation

OTHER

Sponsor Role collaborator

University of Oxford

OTHER

Sponsor Role lead

Principal Investigators

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Keith Channon, MD FRCP

Role: PRINCIPAL_INVESTIGATOR

University of Oxford

Locations

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University of Oxford

Oxford, , United Kingdom

Site Status RECRUITING

Countries

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United Kingdom

Central Contacts

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Cheerag C Shirodaria, MB BS MRCP

Role: CONTACT

Phone: +(44)1865-221866

Email: [email protected]

Other Identifiers

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04.OXB.004

Identifier Type: -

Identifier Source: org_study_id