Efficacy Trial to Examine Efficacy of Multimicronutrient Home Supplementation in Infants

NCT ID: NCT00276198

Last Updated: 2008-04-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

771 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-07-31

Study Completion Date

2007-12-31

Brief Summary

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The objective of the program is to examine the efficacy of 6 month home micronutrient supplementation in Bedouin and Jewish children on improvements in nutritional status including measures of iron, ferritin, zinc and folic acid, and measures of growth and health parameters i.e.reported and recorded morbidity.

Detailed Description

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The high level of anemia persists in Negev children despite the existence of a policy of the Ministry of Health that calls for Iron, Vitamin A and Vitamin D supplementation up to 12 months of age. In addition, other micronutrient deficiencies in this population have been described in several studies. These may be related to; low adherence with existing recommendations; need for additional micronutrients other than Iron, Vitamin A and Vitamin D; the need for a different delivery system more acceptable to mothers and infants.

We will compare in Bedouin and Jewish children separately the efficacy of daily use of Sprinkles(home Micronutrient fortification) from age 6 to 12 months in infants recruited in Maternal and Child Health clinics.

The comparison will be children recruited in clinics of comparable socioeconomic status, where current Ministry of Health recommendations (drops of iron and vitamins A plus D) are the treatment regimen.

Conditions

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Iron Deficiency Anemia Infectious Diseases Undernutrition

Keywords

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Clinical trial, controlled Micronutrients Dietary Supplementation Infants

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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1

Supplementation with daily sprinkle package

Group Type EXPERIMENTAL

Sprinkles

Intervention Type DIETARY_SUPPLEMENT

Daily dosage of fat coated iron (desote fumarate) 12.5 mg, zinc 5mg, vitamin A 300 micrograms, folic acid 150 micrograms, ascorbic acid 50 mg.

2

Supplementation with Iron tonic 15mg, vitamins A 300 micrograms, vitamin D 10 micrograms. According to Ministry of Health routine recommendations.

Group Type ACTIVE_COMPARATOR

Ferripel-3, Vitamins A&D drops

Intervention Type DIETARY_SUPPLEMENT

Daily dosage of Iron tonic 15mg, vitamins A 300 micrograms, vitamin D 10 micrograms once a day from age 6 months up to age 12 months

3

No intervention except for checking outcomes at approprite times.

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Sprinkles

Daily dosage of fat coated iron (desote fumarate) 12.5 mg, zinc 5mg, vitamin A 300 micrograms, folic acid 150 micrograms, ascorbic acid 50 mg.

Intervention Type DIETARY_SUPPLEMENT

Ferripel-3, Vitamins A&D drops

Daily dosage of Iron tonic 15mg, vitamins A 300 micrograms, vitamin D 10 micrograms once a day from age 6 months up to age 12 months

Intervention Type DIETARY_SUPPLEMENT

Other Intervention Names

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oral drops

Eligibility Criteria

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Inclusion Criteria

* Infant aged 5-7 months
* Infant whose parents give their written informed consent
* Infants whose parents intend to reside within the area for at least 12 months
* Infants receiving any additional food besides breast feeding

Exclusion Criteria

* Known or suspected haemotological disorders
* Known or suspected anemia (Hb \<11 gr/dl)
* Known or suspected immunological disorders
* Known or suspected malabsorption disorders
* Enrolled or scheduled to be enrolled in another clinical trial
Minimum Eligible Age

5 Months

Maximum Eligible Age

2 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Soroka University Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Soroka University Medical Center

Principal Investigators

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Drora Fraser, PhD

Role: PRINCIPAL_INVESTIGATOR

Ben-Gurion University of the Negev

Locations

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Ministry of Health

Beersheba, , Israel

Site Status

Countries

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Israel

References

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Fraser D, Shahar D, Shai I, Vardi H, Bilenko N. Negev nutritional studies: nutritional deficiencies in young and elderly populations. Public Health Rev. 2000;28(1-4):31-46.

Reference Type BACKGROUND
PMID: 11411276 (View on PubMed)

Related Links

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http://sghi.org/about_sprinkles/index.html

The site that describes the intervention treatment

Other Identifiers

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sor395705ctil

Identifier Type: -

Identifier Source: org_study_id