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The Effects of Craving and Abstinence From Cigarettes on Brain Metabolism in Smokers

NCT ID: NCT00267813

Last Updated: 2008-05-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

24 participants

Study Classification

INTERVENTIONAL

Study Start Date

2004-07-31

Study Completion Date

2007-10-31

Brief Summary

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Craving and withdrawal from smoking cigarettes are major factors for relapse. We investigated craving for cigarettes in smokers undergoing pharmacological treatment with Bupropion (Zyban). We compare cue-induced reactivity to smoking videos in smokers who were successfully treated with Bupropion to smokers who are still smoking. We measured the brain's metabolic activity in response to smoking and neutral cues in Positron Emission Tomography using FDG.

Detailed Description

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Craving and withdrawal from smoking cigarettes are major factors for relapse. We investigated craving for cigarettes in smokers undergoing pharmacological treatment with Bupropion (Zyban)for 2 months. We compare cue-induced reactivity to smoking videos in smokers who were successfully treated with Bupropion to smokers who are still smoking. We measured the brain's metabolic activity after exposure to videotapes showing smoking and neutral scenes in Positron Emission Tomography using FDG. There were 2 scanning sessions, one with a smoking videotape and one with a neutral video separated by a week. So far we have compared the brain's metabolic activity in 6 abstinent smokers and 6 still smokers.

Conditions

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Nicotine Dependence

Keywords

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craving nicotine imaging FDG PET smoking Bupropion

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Interventions

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Bupropion (Zyban)

1 tablet a day increasing to 2 tablets a day after a week

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Cigarette smokers (over 1 pack a day)
* Age 20-65, male-females

Exclusion Criteria

* Dependence on other substances
* Psychiatric diagnosis
* Neurological disorder
* Obesity
* Young persons
* Pregnant women
Minimum Eligible Age

20 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Tel-Aviv Sourasky Medical Center

OTHER_GOV

Sponsor Role lead

Responsible Party

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Sourasky Medical Center Tel Aviv

Principal Investigators

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Einat Even-Sapir, M.D, Ph.D

Role: PRINCIPAL_INVESTIGATOR

Tel-Aviv Sourasky Medical Center

Aviv M Weinstein, Ph.D

Role: PRINCIPAL_INVESTIGATOR

Tel-Aviv Sourasky Medical Center

Hedva Lerman, M.D

Role: STUDY_DIRECTOR

Tel-Aviv Sourasky Medical Center

Locations

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Department of Nuclear Medicine

Tel Aviv, , Israel

Site Status

Countries

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Israel

References

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Weinstein A, Greif J, Yemini Z, Lerman H, Weizman A, Even-Sapir E. Attenuation of cue-induced smoking urges and brain reward activity in smokers treated successfully with bupropion. J Psychopharmacol. 2010 Jun;24(6):829-38. doi: 10.1177/0269881109105456. Epub 2009 Jul 31.

Reference Type DERIVED
PMID: 19648219 (View on PubMed)

Other Identifiers

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TASMC-O5-EE-065-CTIL

Identifier Type: -

Identifier Source: org_study_id