Brain Reaction to Treatment of Nicotine Dependence

NCT ID: NCT00108173

Last Updated: 2013-04-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

104 participants

Study Classification

INTERVENTIONAL

Study Start Date

2002-10-31

Study Completion Date

2011-06-30

Brief Summary

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The purpose of the study was to determine how the treatments for cigarette craving work.

Hypothesis: During exposure to cigarette-related cues, heavy smokers will have greater reductions in regional brain activation from before to after both forms of active treatments than from before to after placebo.

Detailed Description

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PET and fMRI scanning were used to examine brain activity and activation in cigarette smokers in response to cigarette-related cues.

Conditions

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Nicotine Dependence

Study Design

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Intervention Model

PARALLEL

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Arm 1

Group Type OTHER

Zyban

Intervention Type DRUG

Interventions

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Zyban

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Heavy smoker, more than one pack per day
* Free of medical conditions or medications that affect brain activity
* Not pregnant

Exclusion Criteria

Drug or alcohol dependence Mental Illness Pregnancy Medications that affect brain function Unstable medical conditions
Minimum Eligible Age

21 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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US Department of Veterans Affairs

FED

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Arthur L. Brody, MD

Role: PRINCIPAL_INVESTIGATOR

VA Greater Los Angeles Healthcare System, West LA

Locations

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VA Greater Los Angeles Healthcare System, West LA

West Los Angeles, California, United States

Site Status

Countries

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United States

Other Identifiers

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ADRD-018-02S

Identifier Type: -

Identifier Source: org_study_id

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