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Effect Of Nicotine on Neurocognitive Performance of Cigarette Smokers

NCT ID: NCT00429208

Last Updated: 2007-01-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-02-28

Study Completion Date

2007-04-30

Brief Summary

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This research project addresses the hypothesis that a neurocognitive profile characterized by impairment of response inhibition and sustained attention may be a risk factor for smoking initiation and nicotine dependence among young women. Nicotine has short- term, facilitating effects on attention and response inhibition. Therefore, individuals who are impaired on cognitive functions such as these and initiate cigarette smoking may be more likely to maintain the habit and develop nicotine dependence. The research protocol specifically tests whether administration of nicotine to non-abstinent, regular cigarette smokers improves cognitive function in those domains where the participants had previously been shown to manifest performance deficits

Detailed Description

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Conditions

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Nicotine Dependence Smoking Tobacco Use Disorder Nicotine Use Disorder

Keywords

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Nicotine Dependence Smoking Tobacco Use Disorder Nicotine Use Disorder

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

DOUBLE

Interventions

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Nicotine

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Reported smoking cigarettes on a daily basis at the time of the original study and continue to smoke currently
* Manifested poor performance on the MFFT (The neurocognitive test that yielded differences between smokers and non-smokers)
* Competent and willing to give written informed consent

Exclusion Criteria

* Pregnancy, breast-feeding, non-use of contraception such that the possibility of pregnancy cannot be excluded
* Intake of any medication that may potentially interact with nicotine.
* Any current or past medical condition that represents a contra-indication to nicotine administration.
Minimum Eligible Age

18 Years

Maximum Eligible Age

30 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Hadassah Medical Organization

OTHER

Sponsor Role lead

Principal Investigators

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Avi Yakir, MD

Role: PRINCIPAL_INVESTIGATOR

Hadassah Medical Organization

Locations

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Hadassah Medical Organization

Jerusalem, , Israel

Site Status

Countries

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Israel

Central Contacts

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Avi Yakir, MD

Role: CONTACT

Phone: 00 972 2 6777184

Email: [email protected]

Hadas Lemberg, PhD

Role: CONTACT

Phone: 00 972 2 6777572

Email: [email protected]

Facility Contacts

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Arik Tzukert, DMD

Role: primary

Hadas Lemberg, PhD

Role: backup

References

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Yakir A, Rigbi A, Kanyas K, Pollak Y, Kahana G, Karni O, Eitan R, Kertzman S, Lerer B. Why do young women smoke? III. Attention and impulsivity as neurocognitive predisposing factors. Eur Neuropsychopharmacol. 2007 Apr;17(5):339-51. doi: 10.1016/j.euroneuro.2006.09.004. Epub 2006 Nov 30.

Reference Type RESULT
PMID: 17141485 (View on PubMed)

Other Identifiers

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yakir@hmo

Identifier Type: -

Identifier Source: org_study_id