Effect of BNP (Brain Natriuretic Peptides) on Endothelial Dysfunction Induced by Coronary Angioplasty

NCT ID: NCT00262574

Last Updated: 2011-08-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE4

Total Enrollment

500 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-07-31

Study Completion Date

2013-06-30

Brief Summary

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Patients receiving BNP or nitroglycerin (IV) during the angioplasty procedure. 24 h after the procedure, vascular reactivity will be re-examined using the brachial artery flow-mediated dilatation study. Blood assays for ET-1, pro-BNP, and various inflammatory markers will be checked before and 24 h after the procedure. It is our hypothesis that endothelial function will be better in the BNP treated patients compared to the NTG treated patients

Detailed Description

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Conditions

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Coronary Artery Disease

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Interventions

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Nesiritide,

PCI

Intervention Type DRUG

Eligibility Criteria

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Exclusion Criteria

\-
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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The Baruch Padeh Medical Center, Poriya

OTHER_GOV

Sponsor Role lead

Responsible Party

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Israell health ministry

Principal Investigators

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Mina Arinos

Role: PRINCIPAL_INVESTIGATOR

Ministry of Health, Israel

Locations

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The Baruch Pade medical center, Poriya

Tiberias, , Israel

Site Status RECRUITING

Countries

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Israel

Central Contacts

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Yonathan Hasin, prof.

Role: CONTACT

97246652649

Diab gahnim, Dr

Role: CONTACT

Other Identifiers

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20020474-Hasin-BNP.CTIL

Identifier Type: -

Identifier Source: org_study_id

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