Investigation of Coagulation Parameters in Hereditary Haemorrhagic Telangiectasia
NCT ID: NCT00230659
Last Updated: 2023-09-28
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
100 participants
OBSERVATIONAL
2004-08-31
2008-07-31
Brief Summary
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Detailed Description
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We hypothesize that the genetically-determined abnormality in the blood vessels of HHT patients leads to alteration in the concentrations or activity of one or several of the proteins which affect blood clotting leading to a hypercoagulable state.
We propose to study levels and activity of blood coagulation factors in people with hereditary haemorrhagic telangiectasia and in normal volunteers. This should define the significance and basis for our initial observations, and will have significant implications for the clinical management of HHT patients.
Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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HHT patients
Patients with hereditary haemorrhagic telangiectasia. Blood sample to be taken.
Blood sample to be taken.
Blood sample to be taken.
Controls
People without hereditary haemorrhagic telangiectasia. Blood sample to be taken.
Blood sample to be taken.
Blood sample to be taken.
Interventions
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Blood sample to be taken.
Blood sample to be taken.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
ALL
Yes
Sponsors
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Hammersmith Hospitals NHS Trust
OTHER
Imperial College London
OTHER
Responsible Party
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Principal Investigators
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Claire Shovlin
Role: PRINCIPAL_INVESTIGATOR
Imperial College London
Locations
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Imperial College Hammersmith Campus
London, , United Kingdom
Countries
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References
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Shovlin CL, Sulaiman NL, Govani FS, Jackson JE, Begbie ME. Elevated factor VIII in hereditary haemorrhagic telangiectasia (HHT): association with venous thromboembolism. Thromb Haemost. 2007 Nov;98(5):1031-9.
Livesey JA, Manning RA, Meek JH, Jackson JE, Kulinskaya E, Laffan MA, Shovlin CL. Low serum iron levels are associated with elevated plasma levels of coagulation factor VIII and pulmonary emboli/deep venous thromboses in replicate cohorts of patients with hereditary haemorrhagic telangiectasia. Thorax. 2012 Apr;67(4):328-33. doi: 10.1136/thoraxjnl-2011-201076. Epub 2011 Dec 14.
Shovlin CL, Chamali B, Santhirapala V, Livesey JA, Angus G, Manning R, Laffan MA, Meek J, Tighe HC, Jackson JE. Ischaemic strokes in patients with pulmonary arteriovenous malformations and hereditary hemorrhagic telangiectasia: associations with iron deficiency and platelets. PLoS One. 2014 Feb 19;9(2):e88812. doi: 10.1371/journal.pone.0088812. eCollection 2014.
Other Identifiers
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IC/CLS6
Identifier Type: -
Identifier Source: org_study_id
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