Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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SUSPENDED
NA
40 participants
INTERVENTIONAL
2005-01-31
Brief Summary
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We, the researchers at Radboud University Nijmegen Medical Centre, have recently developed a method in which we can detect ischemia-reperfusion injury in the human forearm by using Annexin A5 scintigraphy (Rongen et al). With this method we will determine whether opioid receptors are involved in ischemic preconditioning. We expect to find that morphine can mimic ischemic preconditioning and that acute ischemic preconditioning can be blocked with the opioid receptor antagonist naloxon. This study will increase our knowledge about the mechanism of ischemic preconditioning and may also provide leads to exploit this endogenous protective mechanism in a clinical setting.
Detailed Description
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Conditions
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Keywords
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Study Design
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RANDOMIZED
CROSSOVER
DOUBLE
Interventions
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morphine
naloxone
Technetium-TC99m-labeled Annexin A5
forearm ischemic exercise
ten minute forearm ischemia
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
18 Years
50 Years
MALE
Yes
Sponsors
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Radboud University Medical Center
OTHER
Principal Investigators
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Gerard Rongen, MD, Phd
Role: PRINCIPAL_INVESTIGATOR
Radboud University Nijmegen Medical Centre / Department of Pharmacology and Toxicology
Locations
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Radboud University Nijmegen Medical Centre / Department of Pharmacology and Toxicology
Nijmegen, Gelderland, Netherlands
Countries
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References
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Rongen GA, Oyen WJ, Ramakers BP, Riksen NP, Boerman OC, Steinmetz N, Smits P. Annexin A5 scintigraphy of forearm as a novel in vivo model of skeletal muscle preconditioning in humans. Circulation. 2005 Jan 18;111(2):173-8. doi: 10.1161/01.CIR.0000151612.02223.F2. Epub 2004 Dec 27.
Other Identifiers
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OPIRI
Identifier Type: -
Identifier Source: org_study_id