Cohort Study Comparing Short Daily Hemodialysis (HD) With Conventional HD

NCT ID: NCT00182156

Last Updated: 2022-04-15

Basic Information

• Recruitment Status: WITHDRAWN
• Study Classification: OBSERVATIONAL
• Study Start Date: 2004-10-31
• Study Completion Date: 2008-12-31

Brief Summary

This study is examining the effects of short daily hemodialysis on platelet function, fluid volume control, arterial stiffness and patient quality of life, as compared to conventional hemodialysis.

Detailed Description

Bleeding is a common cause of morbidity and mortality in patients with end stage renal disease. A major cause of uremic bleeding is due to platelet dysfunction. It has been theorized that in renal failure, toxins accumulate, some of which inhibit primary hemostasis. All aspects of normal platelet function are affected. Platelet function has previously been difficult to quantify but recently a novel test, the platelet function analyzer (PFA-100) has been determined to be both sensitive and specific in assessing platelet function. Conventional hemodialysis (CHD) has been shown to partially correct thrombocytopathy. Enhanced uremic clearance can now be attained through the use of short daily hemodialysis (SDHD). Cardiovascular disease is the most common cause of mortality in dialysis patients, accounting for 40% of deaths. Volume overload is associated with high blood pressure, left ventricular hypertrophy and elevated markers of inflammation and these factors have been associated with increased cardiovascular mortality. SDHD has been shown to control blood pressure and limit volume expansion. Pulse wave velocity (PWV) has been used to assess arterial compliance and reduction of arterial elasticity of large and small arteries which have been associated with cardiovascular outcomes.

Conditions

End-stage Renal Disease; Thrombocytopathy; Cardiovascular Diseases

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

1

conventional HD

No interventions assigned to this group

2

short daily HD

No interventions assigned to this group

3

PD

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• Patient is enrolled in short daily hemodialysis program
• Patient is minimum of 18 years old

Exclusion Criteria

• Patient is unable to consent due to language barrier
• Patient is unable to consent due to cognitive difficulties
• Patient refuses consent

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

St. Joseph's Healthcare Hamilton

OTHER

Sponsor Role: collaborator

McMaster University

OTHER

Sponsor Role: lead

Responsible Party

Azim Gangji

Associate professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Azim Gangji, MD

Role: PRINCIPAL_INVESTIGATOR

Clinical Scholar, Medicine

Catherine M Clase, MD

Role: PRINCIPAL_INVESTIGATOR

Associate Professor, Medicine

Locations

St. Joseph's Healthcare

Hamilton, Ontario, Canada

Countries

Canada

Other Identifiers

Nephrology Divisional Funds

Identifier Type: -

Identifier Source: org_study_id