Magnetic Resonance Spectroscopy Studies of Cardiac Muscle Metabolism

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

500 participants

Study Classification

OBSERVATIONAL

Study Start Date

1988-01-31

Study Completion Date

2028-08-31

Brief Summary

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The metabolism of the heart provides the chemical energy needed to fuel ongoing normal heart contraction. Magnetic resonance spectroscopy is a technique used in a MRI scanner that can be used to measure and study heart metabolism directly but without blood sampling or obtaining tissue biopsies. One of the hypotheses this study aims to investigate is whether energy metabolism is reduced in heart failure and whether that contributes to the poor heart function.

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Detailed Description

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This study uses magnetic resonance (MR) spectroscopy to study heart metabolism and function in normal subjects and patients with left ventricular hypertrophy, dilated cardiomyopathy, and those with coronary artery disease.

Conditions

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Heart Failure, Congestive

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* age \> 18 years
* Healthy subjects: no history of heart disease
* Dilated cardiomyopathy: history of heart failure, ejection fraction (EF) \<40%
* Left ventricular hypertrophy: wall thickness \>1.2cm
* Coronary artery disease: \>50% coronary lesion or positive stress test