C-Reactive Protein as a Predictor of Stem Cell Transplant Complications

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

70 participants

Study Classification

OBSERVATIONAL

Study Start Date

2003-01-31

Study Completion Date

2008-02-29

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to determine if C-Reactive Protein levels are predictive for complications post transplant.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Markers of Inflammation in Hematopoietic Stem Cell Transplant

NCT00579397

Acute Graft Versus Host Disease

COMPLETED

Predictive Biomarkers For Pediatric Chronic Graft-Versus-Host Disease

NCT02067832

Chronic Graft vs Host Disease

ACTIVE_NOT_RECRUITING

Retrospective Study of Viral Reactivation Across All Bone Marrow Transplant Protocols Since 2010

NCT03111745

Viral Infections

COMPLETED

Analysis of T Cell and Natural Killer (NK) Cell in Relation to Viral Infections in Pediatric Stem Cell Transplant Patients and Donors

NCT02301065

Hematologic Malignancies

COMPLETED

Biomarkers in Transplant Recipients to Improve Outcomes

NCT01163578

Solid Organ Transplantation Bone Marrow Transplantation

RECRUITING

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Cancer Leukemia Stem Cell Transplantation

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

C-Reactive Protein levels

Each patient enrolled in the study will have a serum quantitative c-reactive protein (crp) level drawn on the day of transplant, day 7 of transplant, and twice weekly after that until recovery of neutrophil count (approximately 20-25 days). Patients will be followed for 100 days post-transplant for the development of the following complications:

1. Sepsis- defined as fever, positive blood culture, need for fluid resuscitation and/or pressor support.
2. Acute GVHD \> grade II defined according to the Seattle criteria
3. VOD- defined according to the modified Seattle criteria

Intervention Type BEHAVIORAL

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Age 6 months to 20 years
* Patient undergoing a stem cell transplant (allogeneic, syngeneic, or autologous) at Childrens' Memorial Hospital
* IRB approved informed consent (and assent for children age 12-17)

Minimum Eligible Age

6 Months

Maximum Eligible Age

20 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No