Genetic Determinants of Warfarin Anticoagulation Effect
NCT ID: NCT00162435
Last Updated: 2018-06-12
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
500 participants
INTERVENTIONAL
2002-08-31
2020-12-31
Brief Summary
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1. Evaluation of the relationship between genetic polymorphisms in the genes encoding for CYP2C9, VKORC1 and factor VII and warfarin maintenance dose at steady state. This study is a confirmation of previous data in our own population.
2. Evaluation of relationship between genetic polymorphisms in the genes encoding for CYP2C9, VKORC1 and factor VII and warfarin loading dose during the induction period.
3. Testing the hypothesis that warfarin loading based on the individual's combined CYP2C9, VKORC1 and factor VII genotype may be more efficient and associated with reduced adverse drug effects.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Genetic
Warfarin
Control
Warfarin
Interventions
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Warfarin
Eligibility Criteria
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Inclusion Criteria
* Desired therapeutic range \>2 and \<3
Exclusion Criteria
18 Years
ALL
No
Sponsors
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United States - Israel Binational Science Foundation
OTHER
Israel Science Foundation
OTHER
Ministry of Health, Israel
OTHER_GOV
Hadassah Medical Organization
OTHER
Responsible Party
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Principal Investigators
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Yoseph Caraco, MD
Role: PRINCIPAL_INVESTIGATOR
Hadassah Medical Organization
Locations
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Hadassah Medical Organization
Jerusalem, , Israel
Countries
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Central Contacts
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Facility Contacts
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References
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Caraco Y, Blotnick S, Muszkat M. CYP2C9 genotype-guided warfarin prescribing enhances the efficacy and safety of anticoagulation: a prospective randomized controlled study. Clin Pharmacol Ther. 2008 Mar;83(3):460-70. doi: 10.1038/sj.clpt.6100316. Epub 2007 Sep 12.
Other Identifiers
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yc19553-HMO-CTIL
Identifier Type: -
Identifier Source: org_study_id
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