Open Label Safety and Efficacy Study of Levetiracetam in Patients With Epilepsy

NCT ID: NCT00160654

Last Updated: 2020-08-19

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

251 participants

Study Classification

INTERVENTIONAL

Study Start Date

2003-11-24

Study Completion Date

2006-12-12

Brief Summary

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Community based study assessing safety and efficacy of levetiracetam in partial onset seizures.

The optimal dose in daily clinical practice will be used.

Detailed Description

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Conditions

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Epilepsy, Partial

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Levetiracetam

Subjects received open-label Levetiracetam.

Group Type EXPERIMENTAL

Levetiracetam

Intervention Type DRUG

* Pharmaceutical form: oral tablets
* Concentration: 500 mg
* Route of administration: Oral use

Interventions

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Levetiracetam

* Pharmaceutical form: oral tablets
* Concentration: 500 mg
* Route of administration: Oral use

Intervention Type DRUG

Other Intervention Names

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Keppra

Eligibility Criteria

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Inclusion Criteria

* Subjects with epilepsy experiencing partial seizures, whether or not secondarily generalized.
* Subjects must present between 3 and 42 partial seizures over the three months prior to protocol Visit 1.
* Use of one (1), but no more than two (2) concomitant marketed antiepileptic drugs (AEDs) at the time of trial entry.

Exclusion Criteria

* Subjects on vigabatrin, whose visual field has not been assessed as per recommendation of the manufacturer, i.e. every 6 months.
* Presence of known pseudoseizures within the last year.
* Presence of progressive cerebral disease, any other progressively degenerative neurological disease, or any cerebral tumors.
* Uncountable seizures (clusters) or history of convulsive status epilepticus within the last five years.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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UCB Pharma

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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UCB Cares

Role: STUDY_DIRECTOR

UCB (+1 844 599 2273)

Locations

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N01036 808

Hong Kong, , Hong Kong

Site Status

N01036 842

Hong Kong, , Hong Kong

Site Status

N01036 815

Kwun Tong, , Hong Kong

Site Status

N01036 811

Kuala Lumpur, , Malaysia

Site Status

N01036 812

Kuala Lumpur, , Malaysia

Site Status

N01036 813

Kuala Lumpur, , Malaysia

Site Status

N01036 830

Manila, , Philippines

Site Status

N01036 831

Manila, , Philippines

Site Status

N01036 829

Quezon, , Philippines

Site Status

N01036 804

Singapore, , Singapore

Site Status

N01036 806

Singapore, , Singapore

Site Status

N01036 807

Singapore, , Singapore

Site Status

N01036 828

Changhua, , Taiwan

Site Status

N01036 827

Hualien City, , Taiwan

Site Status

N01036 825

Kaohsiung City, , Taiwan

Site Status

N01036 834

Kaohsiung City, , Taiwan

Site Status

N01036 835

Kaohsiung City, , Taiwan

Site Status

N01036 817

Taichung, , Taiwan

Site Status

N01036 823

Taichung, , Taiwan

Site Status

N01036 818

Tainan City, , Taiwan

Site Status

N01036 819

Taipei, , Taiwan

Site Status

N01036 820

Taipei, , Taiwan

Site Status

N01036 821

Taipei, , Taiwan

Site Status

N01036 822

Taoyuan District, , Taiwan

Site Status

N01036 809

Bangkok, , Thailand

Site Status

N01036 840

Bangkok, , Thailand

Site Status

N01036 841

Bangkok, , Thailand

Site Status

N01036 839

Chiang Mai, , Thailand

Site Status

N01036 810

Khon Kaen, , Thailand

Site Status

Countries

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Hong Kong Malaysia Philippines Singapore Taiwan Thailand

References

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Kwan P, Lim SH, Chinvarun Y, Cabral-Lim L, Aziz ZA, Lo YK, Tonner F, Beh K, Edrich P; N01036 (SKATE II) Investigator Group. Efficacy and safety of levetiracetam as adjunctive therapy in adult patients with uncontrolled partial epilepsy: the Asia SKATE II Study. Epilepsy Behav. 2010 May;18(1-2):100-5. doi: 10.1016/j.yebeh.2010.03.016. Epub 2010 May 11.

Reference Type RESULT
PMID: 20462804 (View on PubMed)

Related Links

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Other Identifiers

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N01036

Identifier Type: -

Identifier Source: org_study_id

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