Long-Term, Follow-Up Study Of the Safety And Efficacy Of Levetiracetam In Children With Partial Onset Seizures

NCT ID: NCT00152516

Last Updated: 2013-02-12

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

255 participants

Study Classification

INTERVENTIONAL

Study Start Date

2004-10-31

Study Completion Date

2008-06-30

Brief Summary

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To allow pediatric patients with partial onset seizures an opportunity to receive (as follow-up to studies N01009(NCT00105040)/N01103(NCT00175890) or by direct enrollment) open-label levetiracetam treatment, continue studying cognition and behavior in children, and continue collection of safety/efficacy data.

Detailed Description

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Conditions

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Epilepsy, Partial

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Levetiracetam

Group Type EXPERIMENTAL

levetiracetam (LEV)

Intervention Type DRUG

Per protocol oral tablets or oral solution at 10 to 30mg/kg/day bid for 48 weeks, or approximately 52 weeks should a subject choose to discontinue levetiracetam (LEV) at the end of the maintenance period.

Interventions

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levetiracetam (LEV)

Per protocol oral tablets or oral solution at 10 to 30mg/kg/day bid for 48 weeks, or approximately 52 weeks should a subject choose to discontinue levetiracetam (LEV) at the end of the maintenance period.

Intervention Type DRUG

Other Intervention Names

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Keppra

Eligibility Criteria

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Inclusion Criteria

* Pediatric patients with partial onset seizures, with 1 to 2 anti-epileptic drugs (AEDS), with participation in previous levetiracetam pediatric studies (N01009 or N01103) or direct enrollment, for whom levetiracetam treatment will be of possible benefit

Exclusion Criteria

* Patients on a ketogenic diet
* Seizures too close together to accurately count
* Pseudoseizures
* Status epilepticus 1 month prior Visit 1
* Current diagnosis of Lennox-Gastaut Syndrome or epilepsy secondary to a progressing cerebral disease will be excluded from the study.
Minimum Eligible Age

1 Month

Maximum Eligible Age

16 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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UCB Pharma

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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UCB Clinical Trial Call Center

Role: STUDY_DIRECTOR

+1 877 822 9493

Locations

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Mobile, Alabama, United States

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Phoenix, Arizona, United States

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Los Angeles, California, United States

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Denver, Colorado, United States

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Washington D.C., District of Columbia, United States

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Bradenton, Florida, United States

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Loxahatchee Groves, Florida, United States

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Orlando, Florida, United States

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Pensacola, Florida, United States

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Tallahassee, Florida, United States

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Tampa, Florida, United States

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Atlanta, Georgia, United States

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Augusta, Georgia, United States

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Chicago, Illinois, United States

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New Orleans, Louisiana, United States

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Boston, Massachusetts, United States

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Saint Paul, Minnesota, United States

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Lebanon, New Hampshire, United States

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Edison, New Jersey, United States

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Voorhees Township, New Jersey, United States

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Buffalo, New York, United States

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New York, New York, United States

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Rochester, New York, United States

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Syracuse, New York, United States

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Chapel Hill, North Carolina, United States

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Cleveland, Ohio, United States

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Hershey, Pennsylvania, United States

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Philadelphia, Pennsylvania, United States

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Charleston, South Carolina, United States

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Germantown, Tennessee, United States

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Nashville, Tennessee, United States

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Fort Worth, Texas, United States

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Galveston, Texas, United States

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Salt Lake City, Utah, United States

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Norfolk, Virginia, United States

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Richmond, Virginia, United States

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Morgantown, West Virginia, United States

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Milwaukee, Wisconsin, United States

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Brussels, , Belgium

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Leuven, , Belgium

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Campinas, , Brazil

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Curitiba, , Brazil

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Porto Alegre, , Brazil

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Ribeirão Preto, , Brazil

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Rio de Janeiro, , Brazil

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São Paulo, , Brazil

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Vancouver, British Columbia, Canada

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Thornhill, Ontario, Canada

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Toronto, Ontario, Canada

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Brno, , Czechia

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Prague, , Czechia

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Lille, , France

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Paris, , France

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Strasbourg, , France

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Kehl, Kork, Germany

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Berlin, , Germany

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Erlangen, , Germany

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Heidelberg, , Germany

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Jena, , Germany

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Kiel, , Germany

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Budapest, , Hungary

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Hyderabad, , India

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Lucknow, , India

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Mahim Mumbai, , India

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Mumbai, , India

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Pune Maharashtra, , India

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Calambrone, , Italy

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Genoa, , Italy

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Milan, , Italy

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Roma, , Italy

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Mexico City, , Mexico

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Gdansk, , Poland

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Bucharest, , Romania

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Cluj-Napoca, , Romania

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Târgu Mureş, , Romania

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Kalingrad, , Russia

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Moscow, , Russia

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Saint Petersburg, , Russia

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Cape Town, , South Africa

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Capitol Park, , South Africa

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Johannesburg, , South Africa

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Bristol, , United Kingdom

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Cardiff, , United Kingdom

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London, , United Kingdom

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Countries

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United States Belgium Brazil Canada Czechia France Germany Hungary India Italy Mexico Poland Romania Russia South Africa United Kingdom

References

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Pina-Garza JE, Schiemann-Delgado J, Yang H, Duncan B, Hadac J, Hunter SJ. Adjunctive levetiracetam in patients aged 1 month to <4 years with partial-onset seizures: subpopulation analysis of a prospective, open-label extension study of up to 48 weeks. Clin Ther. 2010 Oct;32(11):1935-50. doi: 10.1016/j.clinthera.2010.09.017.

Reference Type RESULT
PMID: 21095488 (View on PubMed)

Related Links

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Other Identifiers

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EudraCT number:2004-000200-40

Identifier Type: -

Identifier Source: secondary_id

N01148

Identifier Type: -

Identifier Source: org_study_id

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