Changes in Nasal Patency With Changes in Posture, Temperature, Humidity and Nasal Patency Seen by Acoustic Rhinometry
NCT ID: NCT00147888
Last Updated: 2013-09-05
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE4
15 participants
INTERVENTIONAL
2004-03-31
2006-12-31
Brief Summary
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Detailed Description
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Eight healthy adult volunteer subjects underwent acoustic rhinometry under the following conditions: 1) upright, sitting position (control), 2) supine position, 3) left lateral recumbent position, 4) one nostril mechanically blocked, 5) icepack on neck, 6) drinking cold water, 7) drinking hot water, 8) nasal nebulizer, 9)oxymetazoline decongestant.
Changes in nasal cavity volumes were detected by acoustic rhinometry after alterations in posture, unilateral mechanical obstruction, temperature, and humidity. Nebulizer treatment and hot water ingestion caused a significant decrease in nasal volume. The nose was able to adapt to environmental and physiological changes in order to maintain a consistent total nasal volume.
Conditions
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Keywords
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Study Design
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NON_RANDOMIZED
SINGLE_GROUP
DIAGNOSTIC
NONE
Interventions
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Acoustic rhinometry (procedure)
Acoustic rhinometry is a procedure that uses sound waves to measure the cross-sectional area and volume of the nasal cavity.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Marked septal deviation/polyposis/infection
* Any history of allergy, asthma or immunodeficiency
* Any systemic condition or infection (e.g., hypertension/diabetes/heart, liver, thyroid or kidney disease
* Any spine or neck condition that would not allow normal postures
* Pregnancy
18 Years
58 Years
ALL
Yes
Sponsors
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Sanofi
INDUSTRY
University of Chicago
OTHER
Responsible Party
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Principal Investigators
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Jacquelynne P. Corey, M.D.
Role: PRINCIPAL_INVESTIGATOR
University of Chicago
Locations
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The University of Chicago
Chicago, Illinois, United States
Countries
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References
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Lundqvist GR, Pedersen OF, Hilberg O, Nielsen B. Nasal reaction to changes in whole body temperature. Acta Otolaryngol. 1993 Nov;113(6):783-8. doi: 10.3109/00016489309135901.
Yamagiwa M, Hilberg O, Pedersen OF, Lundqvist GR. Evaluation of the effect of localized skin cooling on nasal airway volume by acoustic rhinometry. Am Rev Respir Dis. 1990 Apr;141(4 Pt 1):1050-4. doi: 10.1164/ajrccm/141.4_Pt_1.1050.
DRETTNER B. VASCULAR REACTIONS ON THE INTAKE OF FOOD AND DRINK OF VARIOUS TEMPERATURES. Acta Otolaryngol Suppl. 1964;188:SUPPL 188:249+. doi: 10.3109/00016486409134570. No abstract available.
Kase Y, Hilberg O, Pedersen OF. Posture and nasal patency: evaluation by acoustic rhinometry. Acta Otolaryngol. 1994 Jan;114(1):70-4. doi: 10.3109/00016489409126019.
Fouke JM, Jackson AC. Acoustic rhinometry: effects of decongestants and posture on nasal patency. J Lab Clin Med. 1992 Apr;119(4):371-6.
Moinuddin R, Mamikoglu B, Barkatullah S, Corey JP. Detection of the nasal cycle. Am J Rhinol. 2001 Jan-Feb;15(1):35-9. doi: 10.2500/105065801781329473.
Haight JJ, Cole P. Reciprocating nasal airflow resistances. Acta Otolaryngol. 1984 Jan-Feb;97(1-2):93-8. doi: 10.3109/00016488409130968.
Hasegawa M. Nasal cycle and postural variations in nasal resistance. Ann Otol Rhinol Laryngol. 1982 Jan-Feb;91(1 Pt 1):112-4. doi: 10.1177/000348948209100125. No abstract available.
Rundcrantz H. Postural variations of nasal patency. Acta Otolaryngol. 1969 Nov;68(5):435-43. doi: 10.3109/00016486909121582. No abstract available.
Bickford L, Shakib S, Taverner D. The nasal airways response in normal subjects to oxymetazoline spray: randomized double-blind placebo-controlled trial. Br J Clin Pharmacol. 1999 Jul;48(1):53-6. doi: 10.1046/j.1365-2125.1999.00972.x.
Mamikoglu B, Houser S, Akbar I, Ng B, Corey JP. Acoustic rhinometry and computed tomography scans for the diagnosis of nasal septal deviation, with clinical correlation. Otolaryngol Head Neck Surg. 2000 Jul;123(1 Pt 1):61-8. doi: 10.1067/mhn.2000.105255.
Corey JP, Gungor A, Nelson R, Fredberg J, Lai V. A comparison of the nasal cross-sectional areas and volumes obtained with acoustic rhinometry and magnetic resonance imaging. Otolaryngol Head Neck Surg. 1997 Oct;117(4):349-54. doi: 10.1016/S0194-5998(97)70125-6.
Corey JP, Nalbone VP, Ng BA. Anatomic correlates of acoustic rhinometry as measured by rigid nasal endoscopy. Otolaryngol Head Neck Surg. 1999 Nov;121(5):572-6. doi: 10.1016/S0194-5998(99)70058-6.
Hendley JO, Abbott RD, Beasley PP, Gwaltney JM Jr. Effect of inhalation of hot humidified air on experimental rhinovirus infection. JAMA. 1994 Apr 13;271(14):1112-3.
Forstall GJ, Macknin ML, Yen-Lieberman BR, Medendrop SV. Effect of inhaling heated vapor on symptoms of the common cold. JAMA. 1994 Apr 13;271(14):1109-11.
Witek TJ Jr, Canestrari DA, Hernandez JR, Miller RD, Yang JY, Riker DK. Superficial nasal mucosal blood flow and nasal patency following topical oxymetazoline hydrochloride. Ann Allergy. 1992 Feb;68(2):165-8.
Corey JP, Kemker BJ, Nelson R, Gungor A. Evaluation of the nasal cavity by acoustic rhinometry in normal and allergic subjects. Otolaryngol Head Neck Surg. 1997 Jul;117(1):22-8. doi: 10.1016/S0194-59989770201-8.
Mamikoglu B, Houser SM, Corey JP. An interpretation method for objective assessment of nasal congestion with acoustic rhinometry. Laryngoscope. 2002 May;112(5):926-9. doi: 10.1097/00005537-200205000-00027.
Taverner D, Bickford L, Shakib S, Tonkin A. Evaluation of the dose-response relationship for intra-nasal oxymetazoline hydrochloride in normal adults. Eur J Clin Pharmacol. 1999 Sep;55(7):509-13. doi: 10.1007/s002280050665.
Other Identifiers
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13028A
Identifier Type: -
Identifier Source: org_study_id