Study to Establish Bioequivalence of ReFacto AF (BDDrFVIII) With Advate (FLrFVIII) in Hemophilia A

NCT ID: NCT00141843

Last Updated: 2008-04-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-07-31

Study Completion Date

2006-11-30

Brief Summary

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The study will consist of two parts: a safety and efficacy period in which all subjects will participate and a pharmacokinetic analysis period, in which 30 eligible subjects will participate to compare ReFacto AF and Advate bioequivalency and safety and efficacy of ReFacto AF in patients with Hemophilia A.

Detailed Description

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Conditions

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Hemophilia A

Keywords

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Hemophilia A

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Interventions

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ReFacto AF

Intervention Type GENETIC

B-Domain deleted Recombinant Factor VIII

Intervention Type GENETIC

BDDrFVIII

Intervention Type GENETIC

Eligibility Criteria

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Inclusion Criteria

* Male subjects with severe or moderately severe hemophilia A
* A negative past medical history of a Factor VIII inhibitor
* Age greater than or equal to 12 years

Exclusion Criteria

* A history of Factor VIII inhibitors
* Presence of a bleeding disorder in addition to hemophilia
* Known hypersensitivity to hamster protein
Minimum Eligible Age

12 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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Wyeth is now a wholly owned subsidiary of Pfizer

INDUSTRY

Sponsor Role lead

Principal Investigators

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Medical Monitor

Role: STUDY_DIRECTOR

Wyeth is now a wholly owned subsidiary of Pfizer

Trial Manager

Role: PRINCIPAL_INVESTIGATOR

For Germany, [email protected]

Trial Manager

Role: PRINCIPAL_INVESTIGATOR

For Italy, [email protected]

Trial Manager

Role: PRINCIPAL_INVESTIGATOR

For Australia, New Zealand, [email protected]

Trial Manager

Role: PRINCIPAL_INVESTIGATOR

For Netherlands, [email protected]

Trial Manager

Role: PRINCIPAL_INVESTIGATOR

For Sweden, Finland,[email protected]

Trial Manager

Role: PRINCIPAL_INVESTIGATOR

For Hungary, [email protected]

Trial Manager

Role: PRINCIPAL_INVESTIGATOR

For Poland, [email protected]

Trial Manager

Role: PRINCIPAL_INVESTIGATOR

For Belgium, [email protected]

Locations

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Phoenix, Arizona, United States

Site Status

Sacramento, California, United States

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San Diego, California, United States

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Aurora, Colorado, United States

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Atlanta, Georgia, United States

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Iowa City, Iowa, United States

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New Orleans, Louisiana, United States

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Worcester, Massachusetts, United States

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East Lansing, Michigan, United States

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St Louis, Missouri, United States

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New Brunswick, New Jersey, United States

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Buffalo, New York, United States

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New Hyde Park, New York, United States

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Chapel Hill, North Carolina, United States

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Dayton, Ohio, United States

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Hershey, Pennsylvania, United States

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Philadelphia, Pennsylvania, United States

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Nashville, Tennessee, United States

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Houston, Texas, United States

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Salt Lake City, Utah, United States

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Charlottesville, Virginia, United States

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Perth, , Australia

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Leuven, , Belgium

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Helsinki, , Finland

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Le Kremlin-Bicêtre, , France

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Rouen, , France

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Berlin, , Germany

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Münster, , Germany

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Budapest, , Hungary

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Milan, , Italy

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Groningen, , Netherlands

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Auckland, , New Zealand

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Hamilton, , New Zealand

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Lodz, , Poland

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Poznan, , Poland

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Warsaw, , Poland

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Wroclaw, , Poland

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Madrid, , Spain

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Valencia, , Spain

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Malmo, , Sweden

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Stockholm, , Sweden

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Countries

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United States Australia Belgium Finland France Germany Hungary Italy Netherlands New Zealand Poland Spain Sweden

Other Identifiers

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3082B2-310

Identifier Type: -

Identifier Source: org_study_id