Safety and Efficacy of Pimecrolimus Cream 1% in Atopic Disease Modification

NCT ID: NCT00124709

Last Updated: 2011-03-23

Study Results

Results available

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Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

PHASE4

Total Enrollment

1091 participants

Study Classification

INTERVENTIONAL

Study Start Date

2003-10-31

Study Completion Date

2008-11-30

Brief Summary

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This study consists of a 3-year double-blind phase during which patients will receive atopic dermatitis (AD) treatment either with pimecrolimus cream 1% long-term management (LTM) or with a conventional corticosteroid-based treatment (1:1 ratio), followed by a 2 to 3-year open-label (OL) phase (all patients receiving pimecrolimus cream 1% LTM). At the end of the double-blind phase, the two treatment groups will be compared with respect to their efficacy in controlling AD; at the end of the OL phase, the incidence of asthma at the age of 6 years will be compared.

Detailed Description

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Conditions

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Atopic Dermatitis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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1

Pimecrolimus

Group Type EXPERIMENTAL

Pimecrolimus

Intervention Type DRUG

Pimecrolimus cream 1 %

2

Corticosteroid

Group Type ACTIVE_COMPARATOR

Corticosteroid

Intervention Type DRUG

conventional corticosteroid-based treatment

Interventions

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Pimecrolimus

Pimecrolimus cream 1 %

Intervention Type DRUG

Corticosteroid

conventional corticosteroid-based treatment

Intervention Type DRUG

Other Intervention Names

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Elidel

Eligibility Criteria

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Inclusion Criteria

* Diagnosis of atopic dermatitis
* Family history of atopy
* 3 to 18 months of age at baseline
* At least mild atopic dermatitis at baseline (investigator global assessment \[IGA\] greater or equal to 2)
* Clinical evidence of atopic dermatitis for no longer than 3 months

Exclusion Criteria

* Diagnosis of or substantial clinical evidence for food or other allergies at baseline

Other protocol related criteria may apply
Minimum Eligible Age

3 Months

Maximum Eligible Age

18 Months

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Novartis Pharmaceuticals

INDUSTRY

Sponsor Role lead

Responsible Party

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Novartis Pharmaceuticals

Principal Investigators

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Novartis Pharmaceuticals

Role: STUDY_CHAIR

Novartis Pharmaceuticals

Locations

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Alabama Allergy and Asthma Center

Birmingham, Alabama, United States

Site Status

Northwest Arkansas Pediatric Clinic, P.A.

Fayetteville, Arkansas, United States

Site Status

The Children's Clinic of Jonesboro

Jonesboro, Arkansas, United States

Site Status

Southern California Research

Mission Viejo, California, United States

Site Status

Children's Hospital of Orange County

Orange, California, United States

Site Status

Stanford Dermatology Clinic and Clinical Trials Dept

Redwood City, California, United States

Site Status

Capital Allergy Respiratory Disease Center

Sacramento, California, United States

Site Status

Children's Hospital San Diego

San Diego, California, United States

Site Status

Allergy and Asthma Medical Group of Diablo Valley, Inc./ Clinical Research Division

Walnut Creek, California, United States

Site Status

National Jewish Medical and Research Center

Denver, Colorado, United States

Site Status

Dermatology Associates and Research

Coral Gables, Florida, United States

Site Status

Emerald Coast Clinical Research

Pensacola, Florida, United States

Site Status

Children's Memorial Hospital

Chicago, Illinois, United States

Site Status

Indiana University Outpatient Clinical Research

Indianapolis, Indiana, United States

Site Status

Central Kentucky Research Associates

Lexington, Kentucky, United States

Site Status

Dermatology Specialists

Louisville, Kentucky, United States

Site Status

Rx R & D

Metarie, Louisiana, United States

Site Status

Johns Hopkins Hospital

Baltimore, Maryland, United States

Site Status

Children's Hospital - Boston

Boston, Massachusetts, United States

Site Status

Dermatology, PLLC

Ann Arbor, Michigan, United States

Site Status

Mayo Clinic Rochester

Rochester, Minnesota, United States

Site Status

Central Dermatology

St Louis, Missouri, United States

Site Status

Skin Specialists, P.C.

Omaha, Nebraska, United States

Site Status

Dartmouth-Hitchcock Medical Center/Dermatology Section

Lebanon, New Hampshire, United States

Site Status

Children's Medical Group

Hopewell Junction, New York, United States

Site Status

Dermatology Associates of St. Luke's - Roosevelt

New York, New York, United States

Site Status

Calcagno Research and Development

Gresham, Oregon, United States

Site Status

Oregon Health Science University - Dermatology Dept.

Portland, Oregon, United States

Site Status

The Childrens' Hospital of Philadelphia

Philadelphia, Pennsylvania, United States

Site Status

Allegheny General Hospital

Pittsburgh, Pennsylvania, United States

Site Status

Tennessee Clinical Research Center

Nashville, Tennessee, United States

Site Status

Texas Children's Hospital, BCM

Houston, Texas, United States

Site Status

Alpine Medical Group, LLC

Salt Lake City, Utah, United States

Site Status

Granger Medical Clinic

West Valley City, Utah, United States

Site Status

Virginia Clinical Research

Norfolk, Virginia, United States

Site Status

Asthma Inc

Seattle, Washington, United States

Site Status

Countries

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United States

References

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Spergel JM, Boguniewicz M, Schneider L, Hanifin JM, Paller AS, Eichenfield LF. Food Allergy in Infants With Atopic Dermatitis: Limitations of Food-Specific IgE Measurements. Pediatrics. 2015 Dec;136(6):e1530-8. doi: 10.1542/peds.2015-1444.

Reference Type DERIVED
PMID: 26598458 (View on PubMed)

Other Identifiers

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CASM981CUS09

Identifier Type: -

Identifier Source: org_study_id

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