Pimecrolimus Cream 1% Plus Topical Corticosteroid in Patients (2-17 Years of Age) With Severe Atopic Dermatitis

NCT ID: NCT00121381

Last Updated: 2008-01-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

400 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-05-31

Study Completion Date

2007-01-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Atopic dermatitis, also called eczema, is characterized by redness, papulation (skin elevation) and pruritus (skin itching). The active ingredient of pimecrolimus inhibits the T-cell activation. These cells are involved in the inflammatory component of the disease. This study will test the safety of pimecrolimus Cream 1% with topical corticosteroid treatment (commonly used in eczema) in patients with severe atopic dermatitis.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Dermatitis, Atopic

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

1

Pimecrolimus 1 % cream plus topical corticosteroid (TCS)

Group Type EXPERIMENTAL

Pimecrolimus plus topical corticosteroid (TCS)

Intervention Type DRUG

Pimecrolimus 1 % cream plus topical corticosteroid (TCS) twice daily

2

Pimecrolimus vehicle (Placebo) plus topical corticosteroid (TCS)

Group Type PLACEBO_COMPARATOR

Pimecrolimus vehicle (Placebo) plus topical corticosteroid (TCS)

Intervention Type DRUG

twice daily administration

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Pimecrolimus plus topical corticosteroid (TCS)

Pimecrolimus 1 % cream plus topical corticosteroid (TCS) twice daily

Intervention Type DRUG

Pimecrolimus vehicle (Placebo) plus topical corticosteroid (TCS)

twice daily administration

Intervention Type DRUG

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

Elidel

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Severe atopic dermatitis
* 5% of total body surface area (TBSA) affected

Exclusion Criteria

* Concurrent skin diseases (infections)
* Immunocompromised
* Recently received phototherapy or systemic therapy
Minimum Eligible Age

2 Years

Maximum Eligible Age

17 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Novartis

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Novartis

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Novartis Pharmaceuticals

Role: STUDY_CHAIR

Novartis Pharmaceuticals

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Pediatric Care Medical Group, Inc.

Huntington Beach, California, United States

Site Status

Children's Hospital -San Diego

San Diego, California, United States

Site Status

National Jewish Medical and Research Center

Denver, Colorado, United States

Site Status

Dermatology Associates and Research

Coral Gables, Florida, United States

Site Status

Medical College of Georgia - Clinical Investigative Services

Augusta, Georgia, United States

Site Status

Dartmouth Hitchcock Medical Center Section of Dermatology

Lebanon, New Hampshire, United States

Site Status

Wake Forest University School of Medicine Dept. of Dermatology

Winston-Salem, North Carolina, United States

Site Status

Calcagno Research and Development

Gresham, Oregon, United States

Site Status

Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, United States

Site Status

Rhode Island Hospital

Providence, Rhode Island, United States

Site Status

520 Trinity Creek Cove

Cordova, Tennessee, United States

Site Status

Virginia Commonwealth University

Richmond, Virginia, United States

Site Status

A.S.T.H.M.A., Inc

Seattle, Washington, United States

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

CASM981C2439

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Combination Therapy for Atopic Dermatitis
NCT00119158 COMPLETED PHASE4