Study Comparing Two Types of Psychotherapy for Treating Depression and Substance Abuse

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Study Classification

INTERVENTIONAL

Study Start Date

2004-10-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to determine whether Integrated Cognitive Behavioral Therapy or Twelve Step Facilitation Therapy is most effective for treatment of dually diagnosed veterans with depressive and substance use disorders.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Integrated Intervention for Substance Abusers With Depressive Disorders

NCT00018655

COMPLETED PHASE2

Dismantling the Components and Dosing of CBT for Co-Occurring Disorders

NCT02161211

CBT Decoupling CBT Anxiety Reduction CBT Combined

COMPLETED NA

Cognitive Behavioral Therapy Combined With Antidepressants to Reduce HIV Risk and Drug Relapse Among Depressed Intravenous Drug Users

NCT00183768

HIV Infections Depression Substance-Related Disorders

COMPLETED PHASE3

An Integrated Treatment for Comorbid PTSD and Substance Abuse in Adolescents

NCT01825694

Substance Abuse Traumatic Stress

COMPLETED NA

ICBT for Depression - A Factorial Investigation of Kinds of Therapist Support and Self-/Expert-selected Content

NCT04260750

Depressive Disorder, Major Depressive Symptoms

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Depression is the most frequent co-occuring mental health disorder among adults with substance use disorders, and such comorbidity is often associated with poorer treatment outcomes. Although there is an urgent need for effective treatments specific for dual-diagnosis adults, few studies have been conducted to address this need.

Comparison: This study will compare substance use and depression symptoms of individuals in two different psychotherapy groups: Integrated Cognitive Behavioral Therapy and Twelve Step Facilitation Therapy. Symptoms and substance use will be compared during the active treatment phase (24 weeks) and for one year following the end of the active treatment.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Alcohol Abuse Cannabis Abuse Major Depressive Disorder Substance-Related Disorders

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

1

Integrated Cognitive Behavioral Therapy

Group Type EXPERIMENTAL

Integrated Cognitive Behavioral Therapy

Intervention Type BEHAVIORAL

2

Twelve Step Facilitation Therapy

Group Type EXPERIMENTAL

Twelve Step Facilitation Therapy

Intervention Type BEHAVIORAL

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Integrated Cognitive Behavioral Therapy

Intervention Type BEHAVIORAL

Twelve Step Facilitation Therapy

Intervention Type BEHAVIORAL

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Individuals diagnosed with one or more substance use disorders (alcohol, cannabis, and or stimulant abuse/dependence) and an independent co-occurring depressive disorder (major depression or dysthymia) will be included.

Exclusion Criteria

* Individuals with substance induced mood disorders and individuals experiencing persistent psychotic symptoms.
* Those with life threatening or unstable medical illness, neurological disorders, or inability to read will be excluded.
* Individuals currently prescribed steroids, disulfiram, or long acting benzodiazepines will be excluded.

Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No