Role of Fat Tissue in Vitamin D Metabolism

NCT ID: NCT00033826

Last Updated: 2013-05-24

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 41 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2002-04-30
• Study Completion Date: 2007-09-30

Brief Summary

Vitamin D is a fat soluble vitamin that has important effects on calcium (including absorption of calcium from the diet) and bone metabolism. Vitamin D is known to be stored in fat tissue, and it is also present in the circulation. The purpose of this study is to investigate the relationship between levels of vitamin D in fat tissue and in blood.

Detailed Description

Although vitamin D is known to be stored in fat tissue, researchers are not sure about the role that fat tissue plays in vitamin D metabolism. This study will help develop the methodology necessary to further investigate the role of fat tissue in vitamin D metabolism and will assess the relationship between levels of vitamin D in fat tissue and in blood. 50 subjects who are referred for gastric bypass surgery will be enrolled in this study. Subjects will complete questionnaires about their medical history, travel history and food intake. Prior to or during surgery, subjects will be asked to provide a blood sample for selected chemistries related to vitamin D metabolism. During gastric bypass surgery, the surgeon will collect small pieces of fat tissue from the fat under the skin and within the abdomen by surgical biopsy. These samples will be used to refine the methodology for determining the levels of vitamin D in blood and fat tissue and for comparing levels of vitamin D in various tissues.

Conditions

Vitamin D; Adipose Tissue

Study Design

• Observational Model Type: CASE_ONLY
• Study Time Perspective: CROSS_SECTIONAL

Eligibility Criteria

Inclusion Criteria

• Obese patients referred for gastric bypass surgery

Exclusion Criteria

• Patients must not be taking bile acid-sequestering medications or anti-seizure medications

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

NIH

Sponsor Role: collaborator

Tufts University

OTHER

Sponsor Role: lead

Responsible Party

HNRC at Tufts

Principal Investigators

Miriam Blum, MD

Role: PRINCIPAL_INVESTIGATOR

Jean Mayer USDA Human Nutrition Center on Aging at Tufts University

Locations

Tufts-New England Medical Center

Boston, Massachusetts, United States

Countries

United States

Other Identifiers

K23AR047869

Identifier Type: NIH

Identifier Source: secondary_id

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NIAMS-070

Identifier Type: -

Identifier Source: secondary_id

K23AR047869

Identifier Type: NIH

Identifier Source: org_study_id

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