T138067 in Treating Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer That Has Not Responded to Previous Chemotherapy

NCT ID: NCT00022243

Last Updated: 2014-01-06

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: PHASE2
• Study Classification: INTERVENTIONAL
• Study Start Date: 2000-10-31

Brief Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.

PURPOSE: Phase II trial to study the effectiveness of T138067 in treating patients who have locally advanced or metastatic non-small cell lung cancer that has not responded to previous chemotherapy.

Detailed Description

OBJECTIVES: I. Determine the objective tumor response rate in patients with locally advanced or metastatic non-small cell lung cancer who have failed first-line therapy with a taxane when treated with T138067 sodium. II. Determine the qualitative and quantitative toxic effects of this drug in these patients. III. Determine the number of patients who progress when treated with this drug. IV. Determine the duration of response, time to disease progression, and median survival of patients treated with this drug. V. Correlate the toxic effects of this drug with peak plasma levels in this patient population.

OUTLINE: This is a multicenter study. Patients receive T138067 sodium IV over 3 hours on days 1, 8, and 15. Treatment repeats every 21 days in the absence of disease progression or unacceptable toxicity. Patients are followed every 3 months after study completion.

PROJECTED ACCRUAL: A total of 20-35 patients will be accrued for this study within 9 months.

Conditions

Lung Cancer

Study Design

• Primary Study Purpose: TREATMENT

Interventions

batabulin sodium

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

DISEASE CHARACTERISTICS: Histologically confirmed non-small cell lung cancer (NSCLC) Locally advanced or metastatic disease Received a prior first-line taxane (as a single agent or component of a combination regimen) as the only chemotherapy for locally advanced or metastatic disease Any amount of prior adjuvant chemotherapy allowed Bidimensionally measurable disease outside the field of prior radiotherapy Amenable to radiologic imaging techniques No clinically apparent CNS metastases or carcinomatous meningitis

PATIENT CHARACTERISTICS: Age: 18 and over Performance status: Karnofsky 70-100% Life expectancy: At least 12 weeks Hematopoietic: Absolute neutrophil count at least 1,500/mm3 Platelet count at least 100,000/mm3 Hepatic: Bilirubin no greater than 1.5 times upper limit of normal (ULN) AST and ALT no greater than 3 times ULN Albumin greater than 2.5 g/dL No history of Gilbert's syndrome Renal: Creatinine no greater than 1.5 times ULN Other: No other malignancy within the past 5 years except adequately treated basal cell or squamous cell skin cancer or carcinoma in situ of the cervix No other severe disease, infection, or comorbidity that would preclude study participation No known defect of glutathione metabolism Not pregnant or nursing Negative pregnancy test Fertile patients must use effective contraception during and for 3 months after study

PRIOR CONCURRENT THERAPY: Biologic therapy: No concurrent immunotherapy or therapeutic biologic response modifiers No concurrent routine or prophylactic filgrastim (G-CSF) or sargramostim No concurrent epoetin alfa Chemotherapy: See Disease Characteristics At least 4 weeks since prior chemotherapy (6 weeks for mitomycin or nitrosoureas) and recovered No other concurrent cytotoxic chemotherapy Endocrine therapy: No concurrent hormonal therapy for NSCLC Radiotherapy: See Disease Characteristics At least 2 weeks since prior limited-field radiotherapy not involving the hematopoietic bone marrow and recovered At least 4 weeks since prior radiotherapy to no more than 25% of the hematopoietic bone marrow and recovered No prior wide-field radiotherapy to the pelvis No concurrent radiotherapy (including palliative radiotherapy) Surgery: At least 4 weeks since prior major surgery Other: At least 4 weeks since prior investigational agents No concurrent anticonvulsants unless required for study drug-related toxicity No concurrent high-dose acetaminophen (i.e., at least 4 g/day) No other concurrent investigational agents

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Tularik

INDUSTRY

Sponsor Role: lead

Principal Investigators

Sean McCarthy

Role: STUDY_CHAIR

Tularik

Locations

UCSF Cancer Center and Cancer Research Institute

San Francisco, California, United States

Vanderbilt-Ingram Cancer Center

Nashville, Tennessee, United States

Countries

United States

References

Jahan TM, Sandler A, Burris H, et al.: A phase II study of T138067-sodium in prior taxane-treated patients (pts) with locally advanced or metastatic non-small cell lung cancer (NSCLC). [Abstract] Proceedings of the American Society of Clinical Oncology 21: A-1282, 2002.

Reference Type: RESULT

Other Identifiers

TULA-T2002

Identifier Type: -

Identifier Source: secondary_id

VU-000511

Identifier Type: -

Identifier Source: secondary_id

CDR0000068798

Identifier Type: -

Identifier Source: org_study_id