Clinical Trials
Showing trials with last updates posted in 2025.
1
Participants
Tucatinib, Trastuzumab, and Capecitabine With SRS for Brain Metastases From HER-2 Positive Breast Cancer
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2024-01-29
Completion:
2025-12-17
Conditions
Brain Metastases
HER2-positive Breast Cancer
Interventions
COMBINATION_PRODUCT
No Results Yet
70
Participants
A Research Study of a New Medicine NNC0113-6856 in Healthy Males
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2022-08-26
Completion:
2023-03-27
Conditions
Healthy Volunteers
Type 2 Diabetes
Interventions
DRUG
No Results Yet
40
Participants
Assess Safety and Efficacy of Sovateltide in Hypoxic-ischemic Encephalopathy
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2023-09-06
Completion:
2026-11-30
Conditions
Hypoxic-Ischemic Encephalopathy
Neonatal Asphyxia
Neonatal Encephalopathy
Interventions
DRUG
No Results Yet
100
Participants
Epidyolex® in Lennox Gastaut, Dravet Syndrome and Tuberous Sclerosis Complex: an Observational Study in ITALY
Study Type:
OBSERVATIONAL
Last Updated:
2025-12-31
Start Date:
2025-02-24
Completion:
2026-01-31
Conditions
Lennox Gastaut Syndrome
Dravet Syndrome
Tuberous Sclerosis Complex
Interventions
DRUG
No Results Yet
50
Participants
Identification of Human Biomarkers Predictive of Diabetes Remission in Type 2 Diabetes Patient (BARIAKINES)
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2023-02-27
Completion:
2025-12-31
Conditions
Type 2 Diabetes
Interventions
PROCEDURE
No Results Yet
826
Participants
Tranexamic Acid to Reduce Delirium After Gastrointestinal Surgery: the TRIGS-D Trial
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2022-11-01
Completion:
2026-08-13
Conditions
Surgical Site Infection
Dementia
Cognition
Interventions
DRUG
No Results Yet
184
Participants
"Natural" and "Organic" Cigarette Descriptors: Association With Expectancies, Subjective Effects, Topography, and Biomarkers of Exposure Among Daily Smokers
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2022-01-20
Completion:
2024-08-31
Conditions
Smoking Behaviors
Interventions
OTHER
No Results Yet
150
Participants
Lazertinib for NSCLC Harboring Activating EGFR Mutations in TKI naïve Patients
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2023-01-02
Completion:
2026-03-31
Conditions
NSCLC
Interventions
DRUG
No Results Yet
35
Participants
Comparative Effect of Carbon Fiber Orthosis Cuff Design on Preference, Comfort, and Mechanics
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2023-05-17
Completion:
2025-09-29
Conditions
Healthy
Lower Limb Injury
Post-Traumatic Osteoarthritis
Interventions
DEVICE
No Results Yet
63
Participants
Effects of Unilateral Step Training on Gait and Balance in Stroke Patients
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2023-01-01
Completion:
2024-06-30
Conditions
Stroke
Interventions
OTHER
No Results Yet
53
Participants
Tagraxofusp and Azacitidine With Venetoclax in Newly Diagnosed Secondary AML After Hypomethylating Agents
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2024-05-01
Completion:
2027-08-31
Conditions
Acute Myeloid Leukemia
Interventions
DRUG
No Results Yet
120
Participants
Randomized Clinical Trial for Ewing Amputation in the VA
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2026-01-15
Completion:
2030-01-15
Conditions
Peripheral Arterial Disease
Interventions
PROCEDURE
No Results Yet
190
Participants
Testing Olaparib and Temozolomide Versus the Usual Treatment for Uterine Leiomyosarcoma After Chemotherapy Has Stopped Working
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2023-03-30
Completion:
2030-03-09
Conditions
Locally Advanced Uterine Corpus Leiomyosarcoma
Metastatic Uterine Corpus Leiomyosarcoma
Stage III Uterine Corpus Leiomyosarcoma AJCC v8
Stage IV Uterine Corpus Leiomyosarcoma AJCC v8
Unresectable Uterine Corpus Leiomyosarcoma
Interventions
PROCEDURE
DRUG
No Results Yet
342
Participants
Validation of Blood Biomarkers for Alzheimer's Disease
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2022-11-24
Completion:
2025-05-20
Conditions
Alzheimer Disease
Mild Cognitive Impairment
Dementia
Tauopathies
Interventions
DIAGNOSTIC_TEST
No Results Yet
70
Participants
Comorbidity Screening and Referral by Prosthetists
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2022-06-09
Completion:
2023-01-30
Conditions
Limb Ischemia
Low Back Pain
Depression
Neuropathy;Peripheral
Amputation
Interventions
OTHER
No Results Yet
80
Participants
A Long-term Safety and Efficacy Study of Danicopan as an Add-on Therapy to Complement Component 5 Inhibitor (C5i) in Participants With PNH
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2022-10-28
Completion:
2026-07-31
Conditions
Paroxysmal Nocturnal Hemoglobinuria
Interventions
DRUG
No Results Yet
152
Participants
A Study of Mosunetuzumab Alone or With Zanubrutinib in People With Follicular Lymphoma
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2022-05-27
Completion:
2026-12-31
Conditions
Follicular Lymphoma
Lymphoma
Interventions
DRUG
No Results Yet
24
Participants
A Research Study of How the Medicine Ziltivekimab Works in the Body of Chinese Men and Women With Kidney Disease and Inflammation
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2022-05-30
Completion:
2024-06-12
Conditions
Chronic Kidney Disease and Systemic Inflammation
Interventions
DRUG
No Results Yet
116
Participants
VIdeo Telehealth in ALzheimer's: NeuroPsychology (VITAL-NP)
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2022-06-27
Completion:
2024-05-16
Conditions
Suspected Typical Alzheimer's Disease (AD)
Suspected Atypical Alzheimer's Disease (AD)
Interventions
BEHAVIORAL
25
Participants
REDUCED 1 - Renal Denervation Using Ultrasonic Catheter EmitteD Energy Study /
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2022-11-11
Completion:
2025-12-31
Conditions
Uncontrolled Stage 2 Hypertension
Interventions
DEVICE
No Results Yet
60
Participants
A Phase II Study of Cladribine and Low Dose Cytarabine in Combination With Venetoclax, Alternating With Azacitidine and Venetoclax, in Patients With Higher-risk Myeloproliferative Chronic Myelomonocytic Leukemia or Higher-risk Myelodysplastic Syndromes With Excess Blasts
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2022-09-23
Completion:
2027-12-31
Conditions
Myelodysplastic Syndromes
Myeloproliferative Chronic Myelomonocytic Leukemia
Interventions
DRUG
No Results Yet
84
Participants
Intragastric Balloon in Obese Patients With Uncontrolled Asthma
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2023-05-12
Completion:
2029-07-31
Conditions
Obesity
Asthma
Interventions
DEVICE
PROCEDURE
No Results Yet
161
Participants
A Research Study of a New Medicine NNC0519-0130 in Healthy People, People With High Body Weight and People With Type 2 Diabetes.
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2022-04-20
Completion:
2024-04-02
Conditions
Healthy Volunteers (Diabetes Mellitus, Type 2)
Interventions
DRUG
No Results Yet
1726
Participants
Addressing Antihypertensive Medication Adherence Through EHR-enabled Teamlets in Primary Care
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2022-10-06
Completion:
2024-11-11
Conditions
Blood Pressure
Medication Adherence
Interventions
BEHAVIORAL
No Results Yet
332
Participants
A Safety and Efficacy Study of Treatment Combinations With and Without Chemotherapy in Adult Participants With Advanced Upper Gastrointestinal Tract Malignancies
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2022-06-10
Completion:
2027-01-31
Conditions
Gastrointestinal Tract Malignancies
Interventions
DRUG
No Results Yet
609
Participants
Continence After Vaginal Prolapse Surgery
Study Type:
OBSERVATIONAL
Last Updated:
2025-12-31
Start Date:
2022-04-04
Completion:
2025-09-19
Conditions
Pelvic Organ Prolapse
Urinary Incontinence
Interventions
PROCEDURE
No Results Yet
20
Participants
Study of Alterations in Tumor Metabolism Associated With the Development of Immunotherapy Resistance in Melanoma
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2022-05-25
Completion:
2028-05-25
Conditions
Melanoma (Skin)
Interventions
OTHER
No Results Yet
1600
Participants
Safe Treatment for Emergency Presentation for Suicidal Ideation and Behavior in Youth
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2022-10-17
Completion:
2026-12-31
Conditions
Suicide
Suicidal
Self-Harm
Interventions
BEHAVIORAL
No Results Yet
5
Participants
Oncoplastic Partial Mastectomy With Intraoperative Radiation Therapy (IORT) in Early Stage Breast Cancer Patients With Prior History of Chest Wall Radiation.
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2021-12-16
Completion:
2024-10-23
Conditions
IORT-Intra-Operative Radiation Therapy
Interventions
RADIATION
PROCEDURE
No Results Yet
151
Participants
Dexmedetomidine in the Treatment of Agitation Associated With Dementia (TRANQUILITY II)
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2022-04-27
Completion:
2023-04-21
Conditions
Agitation
Dementia
Interventions
DRUG
1300
Participants
A Rollover Study to Evaluate the Long-Term Safety and Efficacy of Ocrelizumab In Patients With Multiple Sclerosis
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2022-05-03
Completion:
2029-12-31
Conditions
Multiple Sclerosis
Interventions
DRUG
No Results Yet
22
Participants
CAR-T Cell Therapy, Mosunetuzumab and Polatuzumab for Treatment of Refractory/Relapsed Aggressive Non-Hodgkin's Lymphoma (NHL).
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2022-12-14
Completion:
2026-12-31
Conditions
Refractory Non-Hodgkin Lymphoma
Relapsed Non Hodgkin Lymphoma
Aggressive Non-Hodgkin Lymphoma
Interventions
DRUG
BIOLOGICAL
No Results Yet
604
Participants
Study of INCB123667 in Subjects With Advanced Solid Tumors
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2022-07-05
Completion:
2027-07-27
Conditions
Solid Tumors
Interventions
DRUG
No Results Yet
15028
Participants
Understanding the Long-term Impact of COVID on Children and Families
Study Type:
OBSERVATIONAL
Last Updated:
2025-12-31
Start Date:
2022-03-01
Completion:
2027-04-01
Conditions
SARS-CoV-2 Infection
No Results Yet
36
Participants
A Study to Learn How Safe the Study Treatment BAY94-9027 is and How it Affects the Body in Previously Treated Children Aged 7 to Less Than 12 Years With Severe Hemophilia A, a Genetic Bleeding Disorder That is Caused by the Lack of a Protein Called Clotting Factor 8 (FVIII) in the Blood
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2022-03-23
Completion:
2024-01-04
Conditions
Treatment of Bleeding
Prophylaxis of Bleeding
Hemophilia A
Children
Interventions
BIOLOGICAL
30
Participants
Mobile-Health Delivery of Lifestyle Interventions for Women With Breast Cancer
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2021-05-21
Completion:
2026-06-15
Conditions
Breast Carcinoma
Interventions
BEHAVIORAL
OTHER
DEVICE
No Results Yet
52
Participants
Neurostimulation to Improve NOWS Outcomes
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2022-07-27
Completion:
2025-01-31
Conditions
Neonatal Opioid Withdrawal Syndrome
Neonatal Abstinence Syndrome
Interventions
DEVICE
No Results Yet
188
Participants
A Study to Evaluate Safety and Efficacy of Ocrelizumab in Comparison With Fingolimod in Children and Adolescents With Relapsing-Remitting Multiple Sclerosis (RRMS)
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2022-05-19
Completion:
2025-06-09
Conditions
Relapsing-Remitting Multiple Sclerosis
Interventions
DRUG
OTHER
No Results Yet
50
Participants
Efficacy and Safety of Sorafenib in Previously Treated Advanced Hepatocellular Carcinoma: SOPT Study
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2022-03-08
Completion:
2025-06-30
Conditions
Advanced Hepatocellular Carcinoma
Interventions
DRUG
No Results Yet
256
Participants
Evaluation of the Impact of Case Manager Intervention on the 3-year Psychotic Episode Recurrence Rate in Patients Aged 16 to 30 Years With a First Psychotic Episode.
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2021-09-27
Completion:
2028-09-30
Conditions
Psychotic Episode
Interventions
OTHER
No Results Yet
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