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Clinical Trials

Showing trials with last updates posted in 2025.

NCT04991103 | RECRUITING | PHASE2
40 Participants

Minimal Residual Disease Response-adapted Deferral of Transplant in Dysproteinemia (MILESTONE)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2021-09-22
Completion: 2027-01-01
Conditions
Multiple Myeloma Amyloidosis
Interventions
DRUG
No Results Yet
NCT04980092 | SUSPENDED
100 Participants

Assessment of Kidney Function and Osteomuscular Status After Critical Care

Study Type: OBSERVATIONAL
Last Updated: 2025-12-31
Start Date: 2023-03-01
Completion: 2026-03-31
Conditions
Critical Illness Kidney Injury Muscle Loss Bone Loss
Interventions
OTHER
No Results Yet
NCT04952779 | COMPLETED
750 Participants

Regulatory Post Marketing Surveillance (rPMS) Study of Xultophy® (Insulin Degludec/Liraglutide) to Evaluate Safety and Effectiveness in Patients With Type 2 Diabetes Mellitus in Routine Clinical Practice in Korea

Study Type: OBSERVATIONAL
Last Updated: 2025-12-31
Start Date: 2021-06-02
Completion: 2024-12-15
Conditions
Diabetes Mellitus, Type 2
Interventions
DRUG
No Results Yet
NCT04930445 | TERMINATED
265 Participants

Oxbryta® Product Registry An Observational Study Designed to Evaluate the Effect of Oxbryta in Individuals With SCD

Study Type: OBSERVATIONAL
Last Updated: 2025-12-31
Start Date: 2022-02-04
Completion: 2024-10-10
Conditions
Sickle Cell Disease
Interventions
DRUG
Results Available
NCT04930159 | ACTIVE_NOT_RECRUITING | NA
252 Participants

Social Interventions for Support During Treatment for Endometrial Cancer and Recurrence

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2021-09-01
Completion: 2026-03-30
Conditions
Endometrial Cancer
Interventions
BEHAVIORAL
No Results Yet
NCT04912505 | COMPLETED | PHASE2
4 Participants

ASPirin in Immune thRombocytopenia Patients With Cardiovascular disEase

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2023-01-16
Completion: 2024-01-02
Conditions
Purpura, Thrombocytopenic
Interventions
DRUG
No Results Yet
NCT04838743 | COMPLETED
244 Participants

GOAL: A Research Study Looking at Long Term Blood Sugar Control in People With Type 2 Diabetes Treated With Xultophy® in Local Clinical Practice in Japan.

Study Type: OBSERVATIONAL
Last Updated: 2025-12-31
Start Date: 2021-04-23
Completion: 2022-10-26
Conditions
Diabetes Mellitus, Type 2
Interventions
DRUG
No Results Yet
NCT04835805 | ACTIVE_NOT_RECRUITING | PHASE1
65 Participants

A Study to Evaluate the Safety and Activity of Belvarafenib as a Single Agent and in Combination With Either Cobimetinib or Cobimetinib Plus Nivolumab in Patients With NRAS-mutant Advanced Melanoma.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2021-05-13
Completion: 2025-12-31
Conditions
Melanoma
Interventions
DRUG
No Results Yet
NCT04821089 | RECRUITING | PHASE1/PHASE2
727 Participants

A Study to Assess the Safety and Efficacy of IPN10200 in Adult Participants With Moderate to Severe Upper Facial Lines

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2021-04-06
Completion: 2026-08-31
Conditions
Moderate to Severe Upper Facial Lines
Interventions
BIOLOGICAL
No Results Yet
NCT04805788 | TERMINATED | PHASE2
9 Participants

Stereotactic Body Proton Radiotherapy for the Treatment of Liver Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2021-08-24
Completion: 2024-02-15
Conditions
Recurrent Hepatocellular Carcinoma Stage I Hepatocellular Carcinoma AJCC v8 Stage II Hepatocellular Carcinoma AJCC v8 Stage III Hepatocellular Carcinoma AJCC v8
Interventions
RADIATION OTHER
No Results Yet
NCT04803214 | ACTIVE_NOT_RECRUITING | NA
203 Participants

ReActiv8 Stimulation Therapy vs Optimal Medical Management: A Randomized Evaluation

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2021-07-14
Completion: 2024-09-04
Conditions
Chronic Low-back Pain
Interventions
DEVICE
Results Available
NCT04800484 | RECRUITING | NA
40 Participants

The Effects of AFO Heel Height and Stiffness on Gait

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2019-11-07
Completion: 2027-01-01
Conditions
Musculoskeletal Injury Musculoskeletal Diseases Peripheral Nervous System Diseases
Interventions
DEVICE
No Results Yet
NCT04779957 | COMPLETED | PHASE2
18 Participants

Evaluation of the Safety of Use of Anti-IL6 Receptor Antibodies to Reduce Allo-sensitization Post Allograft Nephrectomy

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2021-10-01
Completion: 2024-08-09
Conditions
Kidney Transplantation Graft Failure
Interventions
DRUG
No Results Yet
NCT04777409 | ACTIVE_NOT_RECRUITING | PHASE3
1840 Participants

A Research Study Investigating Semaglutide in People With Early Alzheimer's Disease (EVOKE Plus)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2021-05-18
Completion: 2025-09-15
Conditions
Early Alzheimer´s Disease
Interventions
DRUG
No Results Yet
NCT04763980 | RECRUITING | NA
72 Participants

Community-Based Health Coach for Access to Germline Genetic Testing Among African American Men With Prostate Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2021-01-15
Completion: 2027-03-31
Conditions
Prostate Carcinoma
Interventions
OTHER
No Results Yet
NCT04747431 | RECRUITING | PHASE1/PHASE2
30 Participants

A Study of PBFT02 in Participants With FTD and Mutations in the Granulin Precursor (GRN) or C9ORF72 Genes

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2021-09-14
Completion: 2028-08-31
Conditions
Frontotemporal Dementia FTD FTD-GRN Dementia Frontotemporal C9orf72
Interventions
DRUG
No Results Yet
NCT04745221 | RECRUITING | NA
100 Participants

Efficacy and Safety of Auto-FMT in Preventing aGVHD

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2021-03-01
Completion: 2026-03-01
Conditions
Graft Versus Host Disease, Acute
Interventions
OTHER
No Results Yet
NCT04737720 | COMPLETED
1 Participants

Intravenous ACP-501 for Familial LCAT Deficiency (rhLCAT)

Study Type: OBSERVATIONAL
Last Updated: 2025-12-31
Start Date: 2013-01-24
Completion: 2013-12-12
Conditions
Familial LCAT Deficiency
Interventions
DRUG
No Results Yet
NCT04737460 | ACTIVE_NOT_RECRUITING | PHASE1
4 Participants

Study for the Treatment for CLN7 Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2021-05-04
Completion: 2028-02-01
Conditions
CLN7
Interventions
GENETIC
No Results Yet
NCT04708470 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2
55 Participants

A Phase I/II Study of Combination Immunotherapy for Advanced Cancers Including HPV-Associated Malignancies, Small Bowel, and Colon Cancers

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2021-10-05
Completion: 2026-11-30
Conditions
Oropharyngeal Cancer Neck Cancer Human Papillomavirus HPV Anal Cancer Cervical Cancer Penile Cancer Vulvar Cancer Vaginal Cancer Colon Cancer
Interventions
DRUG
No Results Yet
NCT04685200 | RECRUITING
143 Participants

Unraveling the Mechanisms Underlying Primary Sclerosing Cholangitis Through a Multidisciplinary, Integrative Research Approach

Study Type: OBSERVATIONAL
Last Updated: 2025-12-31
Start Date: 2023-03-31
Completion: 2026-10-31
Conditions
Primary Sclerosing Cholangitis
No Results Yet
NCT04660487 | RECRUITING
100 Participants

Relationship Between "FODMAPs" and "GVHD"

Study Type: OBSERVATIONAL
Last Updated: 2025-12-31
Start Date: 2020-12-01
Completion: 2026-12-01
Conditions
Graft Versus Host Disease
No Results Yet
NCT04621435 | RECRUITING | PHASE1
191 Participants

Imaging of Solid Tumors Using FAP-2286

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2020-12-14
Completion: 2026-12-31
Conditions
Solid Tumors, Adult Metastatic Cancer
Interventions
DRUG PROCEDURE
No Results Yet
NCT04609072 | RECRUITING
200000 Participants

Connect for Cancer Prevention Study (Connect)

Study Type: OBSERVATIONAL
Last Updated: 2025-12-31
Start Date: 2021-07-26
Completion: 2070-12-31
Conditions
Cancer General Research Use
No Results Yet
NCT04601857 | TERMINATED | PHASE2
43 Participants

Futibatinib and Pembrolizumab Combination in the Treatment of Advanced or Metastatic Urothelial Carcinoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2021-01-07
Completion: 2024-03-08
Conditions
Advanced and Metastatic Urothelial Cancer
Interventions
DRUG
Results Available
NCT04560673 | RECRUITING | PHASE2
380 Participants

Duloxetine and Neurofeedback Training for the Treatment of Chemotherapy Induced Peripheral Neuropathy

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2020-07-10
Completion: 2026-12-31
Conditions
Chemotherapy-Induced Peripheral Neuropathy Hematopoietic and Lymphoid Cell Neoplasm Malignant Solid Neoplasm
Interventions
DRUG BEHAVIORAL OTHER
No Results Yet
NCT04557969 | RECRUITING
400 Participants

Surgery in Gastrointestinal Stromal Tumors (GISTs) for Treatment, Tumor Modeling, and Genomic Analysis

Study Type: OBSERVATIONAL
Last Updated: 2025-12-31
Start Date: 2020-12-18
Completion: 2040-12-30
Conditions
Gastric Cancer Gastric Neoplasm Gastrointestinal Stromal Sarcoma Gastrointestinal Stromal Neoplasm Gastrointestinal Stromal Tumor (GIST)
No Results Yet
NCT04542733 | RECRUITING | NA
50 Participants

The Efficacy of Everolimus With Reduced-dose Tacrolimus Versus Reduced-dose Tacrolimus and Leflunomide in Treatment of BK Virus Infection in Kidney Transplantation Recipient

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2021-02-10
Completion: 2025-12-24
Conditions
Kidney Transplant Infection BK Virus Infection
Interventions
DRUG
No Results Yet
NCT04469855 | COMPLETED
3217 Participants

Post-Marketing Surveillance (Special Use-results Surveillance) on Long-term Use With Ozempic®

Study Type: OBSERVATIONAL
Last Updated: 2025-12-31
Start Date: 2020-07-27
Completion: 2025-05-12
Conditions
Diabetes Mellitus, Type 2
Interventions
DRUG
No Results Yet
NCT04453917 | COMPLETED | NA
22 Participants

Dynamics of T Cell Expression of Immune Checkpoint Molecules in Progressive Multifocal Leukoencephalopathy

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2021-02-23
Completion: 2024-07-12
Conditions
Progressive Multifocal Leukoencephalopathy
Interventions
BIOLOGICAL DIAGNOSTIC_TEST
No Results Yet
NCT04451135 | ACTIVE_NOT_RECRUITING | NA
31 Participants

CET- REM (Correlating ECT Response to EEG Markers)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2020-10-09
Completion: 2026-06-30
Conditions
ECT Treatment Resistant Depression
Interventions
DIAGNOSTIC_TEST
No Results Yet
NCT04443660 | COMPLETED
97 Participants

Autophagy/Apoptosis Balance During Pregnancy

Study Type: OBSERVATIONAL
Last Updated: 2025-12-31
Start Date: 2020-12-30
Completion: 2024-09-30
Conditions
Pregnancy Related
Interventions
OTHER
No Results Yet
NCT04417660 | RECRUITING | PHASE2
44 Participants

Bintrafusp Alfa (M7824) in Subjects With Thymoma and Thymic Carcinoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2020-12-26
Completion: 2026-03-31
Conditions
Thymic Epithelial Tumor Recurrent Thymoma Thymic Cancer
Interventions
DRUG
No Results Yet
NCT04411147 | ACTIVE_NOT_RECRUITING
583 Participants

A Longitudinal Study of COVID-19 Sequelae and Immunity

Study Type: OBSERVATIONAL
Last Updated: 2025-12-31
Start Date: 2020-06-17
Completion: 2027-12-31
Conditions
COVID-19
No Results Yet
NCT04364217 | WITHDRAWN | NA
0 Participants

Pain and Itch Reduction in Burn Scars Treated With Fractional CO2 Laser

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2020-06-25
Completion: 2025-03-31
Conditions
Hypertrophic Scar Burn Scar
Interventions
DEVICE
No Results Yet
NCT04356755 | RECRUITING | PHASE2
32 Participants

Subcutaneous Injections of ASC to Heal Digital Ulcers in Patients With Scleroderma.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2020-09-22
Completion: 2027-03-31
Conditions
Systemic Sclerosis
Interventions
DRUG
No Results Yet
NCT04353375 | RECRUITING | PHASE2/PHASE3
235 Participants

HMPL-453 Tartrate in Advanced Intrahepatic Cholangiocarcinoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2020-09-03
Completion: 2028-06-30
Conditions
Advanced Intrahepatic Cholangiocarcinoma Solid Tumor, Adult
Interventions
DRUG
No Results Yet
NCT04311606 | COMPLETED | PHASE2
11 Participants

Anti-VEGF Therapy for Acute Thyroid Eye Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2020-11-02
Completion: 2024-12-17
Conditions
Thyroid Eye Disease
Interventions
DRUG
No Results Yet
NCT04307134 | COMPLETED
108 Participants

Besponsa Post Marketing Surveillance Study

Study Type: OBSERVATIONAL
Last Updated: 2025-12-31
Start Date: 2020-07-09
Completion: 2024-12-24
Conditions
Hematologic Malignancy
Interventions
DRUG
Results Available
NCT04297683 | ACTIVE_NOT_RECRUITING | PHASE2/PHASE3
1500 Participants

HEALEY ALS Platform Trial - Master Protocol

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2020-06-14
Completion: 2027-11-30
Conditions
Amyotrophic Lateral Sclerosis
Interventions
DRUG
No Results Yet
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