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Clinical Trials

Showing trials with last updates posted in 2025.

NCT05635747 | ENROLLING_BY_INVITATION
32 Participants

A 90 Day Observational Study as an Extension to the Phase 3,Open Labeled Exploratory Study of RELiZORB

Study Type: OBSERVATIONAL
Last Updated: 2025-12-30
Start Date: 2022-09-29
Completion: 2026-09-29
Conditions
Short Bowel Syndrome Malabsorption
Interventions
DEVICE
No Results Yet
NCT05617625 | SUSPENDED | PHASE2
50 Participants

CD34+ Enriched Transplants to Treat Myelodysplastic Syndrome

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2026-01-31
Completion: 2032-09-30
Conditions
Myelodysplastic Syndromes Graft Vs Host Disease Graft-versus-host-disease
Interventions
DRUG DEVICE
No Results Yet
NCT05614739 | RECRUITING | PHASE1
535 Participants

FORAGER-1: A Study of LOXO-435 (LY3866288) in Participants With Cancer With a Change in a Gene Called FGFR3

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2023-01-12
Completion: 2027-06-30
Conditions
Urinary Bladder Neoplasms Neoplasm Metastasis Ureteral Neoplasms
Interventions
DRUG
No Results Yet
NCT05606614 | RECRUITING | PHASE3
15 Participants

A Phase 1/2/3 Study of TSHA-102 Gene Therapy in Females With Rett Syndrome (REVEAL Pivotal Study)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2023-03-06
Completion: 2031-06-30
Conditions
Rett Syndrome
Interventions
GENETIC
No Results Yet
NCT05600894 | ACTIVE_NOT_RECRUITING | PHASE2
132 Participants

Venetoclax in Combination With ASTX727 for the Treatment of Chronic Myelomonocytic Leukemia and Other Myelodysplastic Syndrome/Myeloproliferative Neoplasm

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2023-06-27
Completion: 2026-08-31
Conditions
Chronic Myelomonocytic Leukemia Myelodysplastic Syndrome Myelodysplastic Syndrome With Excess Blasts Myelodysplastic/Myeloproliferative Neoplasm Myeloproliferative Neoplasm
Interventions
PROCEDURE DRUG
No Results Yet
NCT05587530 | TERMINATED | NA
7 Participants

Zero Suicide Implementation in Outpatient Mental Health Clinics

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2022-11-20
Completion: 2025-05-31
Conditions
Suicide
Interventions
BEHAVIORAL
Results Available
NCT05568615 | COMPLETED | PHASE3
15 Participants

Extension Study Following the Studies MT-1186-A03 or A04 to Evaluate the Safety of Oral Edaravone in Subjects With ALS

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2022-10-26
Completion: 2023-06-27
Conditions
ALS
Interventions
DRUG
Results Available
NCT05565105 | NOT_YET_RECRUITING | PHASE2
100 Participants

CD34+ Transplants for Leukemia and Lymphoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2026-01-31
Completion: 2032-09-30
Conditions
Leukemia, Myeloid, Acute Leukemia, Lymphocytic, Acute
Interventions
RADIATION DRUG
No Results Yet
NCT05556798 | ACTIVE_NOT_RECRUITING | PHASE1
9 Participants

A Study of Belantamab Mafodotin in Combination With Nirogacestat and Pomalidomide in People With Multiple Myeloma That Has Not Responded to Treatment or Has Come Back After Treatment

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2022-10-04
Completion: 2026-10-31
Conditions
Multiple Myeloma
Interventions
DRUG
No Results Yet
NCT05551273 | ACTIVE_NOT_RECRUITING | PHASE2
29 Participants

Study of Oral TLR8 Agonist Selgantolimod on HBsAg in Participants With Both Chronic Hepatitis B and HIV

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2023-05-05
Completion: 2025-10-29
Conditions
Hepatitis B HIV Infections
Interventions
DRUG
No Results Yet
NCT05538663 | RECRUITING | PHASE3
870 Participants

Intravesical BCG vs GEMDOCE in NMIBC

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2023-02-07
Completion: 2029-11-01
Conditions
Non-muscle-invasive Bladder Cancer
Interventions
DRUG
No Results Yet
NCT05532319 | COMPLETED | PHASE2
64 Participants

HAIC Sequential TAE Combined With Lenvatinib and Tislelizumab in Unresectable HCC

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2022-11-10
Completion: 2025-12-23
Conditions
Liver Cancer
Interventions
COMBINATION_PRODUCT
No Results Yet
NCT05494190 | RECRUITING | NA
111 Participants

The Management of Metastatic Neck Nodes in N2/3 Hypopharyngeal Squamous Cell Carcinoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2022-11-01
Completion: 2027-11-30
Conditions
Hypopharyngeal Carcinoma
Interventions
DRUG RADIATION PROCEDURE
No Results Yet
NCT05480384 | ACTIVE_NOT_RECRUITING | PHASE2
1 Participants

Adjuvant Trastuzumab Deruxtecan (Enhertu) & Nivolumab For Patients Who Are Disease Free After Completion of Trimodality Treatment For HER-2+ Cancers of Esophagus & Gastroesophageal Junction

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2023-07-14
Completion: 2025-04-09
Conditions
Esophageal Cancer Esophageal Adenocarcinoma HER-2 Protein Overexpression Gastroesophageal-junction Cancer
Interventions
DRUG
No Results Yet
NCT05470595 | ACTIVE_NOT_RECRUITING | PHASE2
67 Participants

A Single-arm Trial of Atezolizumab/Platinum/Etoposide for the Treatment of Advanced Large-cell Neuroendocrine Cancer of the Lung

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2022-01-18
Completion: 2028-01-31
Conditions
Large Cell Neuroendocrine Carcinoma of the Lung
Interventions
DRUG
No Results Yet
NCT05468320 | COMPLETED | PHASE3
51 Participants

Caplacizumab and Immunosuppressive Therapy Without Firstline Therapeutic Plasma Exchange in Adults With Immune-mediated Thrombotic Thrombocytopenic Purpura

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2022-11-21
Completion: 2024-12-26
Conditions
Thrombotic Thrombocytopenic Purpura
Interventions
DRUG BIOLOGICAL
Results Available
NCT05450172 | COMPLETED
204 Participants

Impact of Postoperative Transitional Pain on Recovery After Thoracic Surgery

Study Type: OBSERVATIONAL
Last Updated: 2025-12-30
Start Date: 2022-10-10
Completion: 2024-03-10
Conditions
Postoperative Recovery
Interventions
OTHER
No Results Yet
NCT05443191 | COMPLETED
50 Participants

A Research Study Looking at How Oral Semaglutide Works in People With Type 2 Diabetes in Finland, as Part of Local Clinical Practice

Study Type: OBSERVATIONAL
Last Updated: 2025-12-30
Start Date: 2022-10-20
Completion: 2023-04-27
Conditions
Diabetes Mellitus, Type 2
Interventions
DRUG
No Results Yet
NCT05436379 | COMPLETED | NA
21 Participants

Treatment, Emotion, and Neuromodulation of Depression (TREND) Study

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2022-06-17
Completion: 2025-11-30
Conditions
Depression
Interventions
DEVICE
No Results Yet
NCT05435508 | COMPLETED | NA
62 Participants

Efficacy of Pain Neuroscience Education and Pre-anesthetic Assessment in Reducing Levels of Anxiety, Stress and Pain in Patients Undergoing Elective Total Abdominal Hysterectomy (ENAH Study)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2024-07-01
Completion: 2025-02-28
Conditions
Pain, Chronic Pain, Postoperative Anesthesia Surgery Anxiety Stress
Interventions
OTHER
No Results Yet
NCT05433168 | COMPLETED | NA
72 Participants

Study Evaluating the Effectiveness of Shiatsu on Fatigue in Patients With Axial Spondyloarthritis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2022-09-20
Completion: 2024-12-10
Conditions
Spondyloarthritis
Interventions
PROCEDURE
No Results Yet
NCT05421806 | ACTIVE_NOT_RECRUITING
500 Participants

A Cohort Study of Use of Doravirine (DOR) Based Regimens in Clinical Practice in Europe DoRavirine Europe Real World/

Study Type: OBSERVATIONAL
Last Updated: 2025-12-30
Start Date: 2022-10-10
Completion: 2026-03-06
Conditions
HIV I Infection
No Results Yet
NCT05411198 | ACTIVE_NOT_RECRUITING | PHASE3
65 Participants

Study to Assess Change in Disease Activity and Adverse Events of Ab Externo Approach for Glaucoma Gel Stent (XEN45) Implantation In Participants Aged 45 Years or Older With Open-Angle Glaucoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2022-07-22
Completion: 2026-01-31
Conditions
Open-Angle Glaucoma
Interventions
DEVICE
No Results Yet
NCT05405114 | COMPLETED | PHASE2
96 Participants

Research Study Investigating How Well NDec Works in People With Sickle Cell Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2022-07-07
Completion: 2025-07-24
Conditions
Sickle Cell Disease
Interventions
DRUG
No Results Yet
NCT05389111 | COMPLETED | NA
76 Participants

Internal Discourses and Perception of Trail-running Effort

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2023-05-15
Completion: 2025-07-25
Conditions
Physical Exertion
Interventions
OTHER
No Results Yet
NCT05388019 | ENROLLING_BY_INVITATION | NA
110 Participants

Multidisciplinary Ventricular Assist Device Clinic

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2022-04-21
Completion: 2026-05-31
Conditions
Heart Failure
Interventions
OTHER BEHAVIORAL
No Results Yet
NCT05377684 | ACTIVE_NOT_RECRUITING
450 Participants

Study of Quality of Life and Hormone Levels in Premenopausal Participants With Early Breast Cancer Receiving Triptorelin Plus Additional Cancer Treatment

Study Type: OBSERVATIONAL
Last Updated: 2025-12-30
Start Date: 2022-06-09
Completion: 2026-06-05
Conditions
Early-stage Breast Cancer
No Results Yet
NCT05330975 | COMPLETED | PHASE3
3317 Participants

A Study of mRNA-1345 Vaccine Targeting Respiratory Syncytial Virus (RSV) in Adults ≥50 Years of Age

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2022-04-01
Completion: 2024-11-08
Conditions
Respiratory Syncytial Virus
Interventions
BIOLOGICAL
Results Available
NCT05313945 | RECRUITING | NA
160 Participants

Evaluation Patient Satisfaction After Passive Bladder Catheter Removal Compared to Active Removal

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2022-07-21
Completion: 2026-03-21
Conditions
Urologic Diseases
Interventions
PROCEDURE
No Results Yet
NCT05307705 | ACTIVE_NOT_RECRUITING | PHASE1
193 Participants

A Study of LOXO-783 in Patients With Breast Cancer/Other Solid Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2022-05-11
Completion: 2025-12-31
Conditions
Breast Cancer
Interventions
DRUG
No Results Yet
NCT05301634 | COMPLETED | PHASE3
60 Participants

Comparison Between Bilateral Infraorbital Block Versus Intranasal Bupivacaine in Transsphenoidal Pituitary Adenoma Resection

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2022-04-02
Completion: 2025-07-30
Conditions
Intraoperative Hypertension
Interventions
PROCEDURE
No Results Yet
NCT05300724 | ACTIVE_NOT_RECRUITING
400 Participants

An Observational Study of the Progression of Intermediate Age-Related Macular Degeneration

Study Type: OBSERVATIONAL
Last Updated: 2025-12-30
Start Date: 2022-05-27
Completion: 2027-06-30
Conditions
Age-Related Macular Degeneration
Interventions
OTHER
No Results Yet
NCT05289687 | RECRUITING | PHASE2
20 Participants

Daratumumab for Chemotherapy-Refractory Minimal Residual Disease in T Cell ALL

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2023-05-25
Completion: 2027-06-30
Conditions
T-cell Acute Lymphoblastic Leukemia
Interventions
DRUG
No Results Yet
NCT05286437 | RECRUITING | PHASE2
40 Participants

Phase II Lenvatinib and Pembrolizumab in Endocrine Resistant Breast Cancer With Letrozole

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2023-02-15
Completion: 2025-12-31
Conditions
Hormone Receptor-Positive HER2-Negative Advanced Breast Cancer
Interventions
DRUG
No Results Yet
NCT05280301 | COMPLETED | NA
7 Participants

Multicenter Sous Vide Frostbite

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2022-12-01
Completion: 2024-11-25
Conditions
Frostbite Frostbite of Hand Frostbite of Foot
Interventions
DEVICE
Results Available
NCT05280184 | COMPLETED | NA
173 Participants

Coin2Dose: Behavioral Economics to Promote Insulin BOLUS Activity and Improve HbA1c in Teens

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2023-01-01
Completion: 2025-06-30
Conditions
Type 1 Diabetes
Interventions
BEHAVIORAL
No Results Yet
NCT05276297 | COMPLETED | PHASE2
174 Participants

A Study on the Safety, Efficacy and Immune Response Following Sequential Treatment With an Anti-sense Oligonucleotide Against Chronic Hepatitis B (CHB) and Chronic Hepatitis B Targeted Immunotherapy (CHB-TI) in CHB Patients Receiving Nucleos(t)Ide Analogue (NA) Therapy

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2022-03-22
Completion: 2025-08-05
Conditions
Hepatitis B, Chronic
Interventions
DRUG BIOLOGICAL
No Results Yet
NCT05273463 | ACTIVE_NOT_RECRUITING | NA
105 Participants

Comparing Perioperative Education Modalities for ACL Reconstruction on Patient Satisfaction, Self-Efficacy, and Surgical Outcomes

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2022-08-23
Completion: 2025-12-02
Conditions
ACL Injury Anterior Cruciate Ligament Injuries
Interventions
BEHAVIORAL
No Results Yet
NCT05267106 | TERMINATED | PHASE2
83 Participants

Study to Evaluate the Efficacy and Safety of Pemigatinib in Participants With Previously Treated Glioblastoma or Other Primary Central Nervous System Tumors Harboring Activating FGFR1-3 Alterations

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2022-05-20
Completion: 2024-12-17
Conditions
Glioblastoma Adult-type Diffuse Gliomas
Interventions
DRUG
Results Available
NCT05259943 | COMPLETED | PHASE2
39 Participants

Microdosing Psychedelics to Improve Mood

Study Type: INTERVENTIONAL
Last Updated: 2025-12-30
Start Date: 2023-07-15
Completion: 2024-12-21
Conditions
Major Depressive Disorder
Interventions
DRUG
No Results Yet
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