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Clinical Trials

Showing trials with last updates posted in 2025.

NCT06480006 | COMPLETED
100 Participants

Validity and Reliability of the BETY-Biopsychosocial Questionnaire in Individuals With Coronary Artery Disease

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2024-06-10
Completion: 2025-05-08
Conditions
Validity Reliability
No Results Yet
NCT06479512 | COMPLETED
200 Participants

Caval-aorta Index and Perfusion Index on Predict Hypotension After Spinal Anaesthesia in Elderly

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2024-07-01
Completion: 2025-04-15
Conditions
Anesthesia, Spinal
Interventions
DEVICE
No Results Yet
NCT06438133 | COMPLETED
52 Participants

Digital Supported Compression Bandaging in Patients With Chronic Edema in the Lower Limbs

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2024-06-10
Completion: 2025-12-18
Conditions
Compression; Vein Venous Insufficiency Lymphedema of Leg Digital Technology
Interventions
OTHER
No Results Yet
NCT06438107 | NOT_YET_RECRUITING
24 Participants

Deep Phenotyping of the Renal Allograft to Prognosticate Clinical Outcomes

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2026-04-30
Completion: 2027-12-31
Conditions
Renal Transplant Rejection
No Results Yet
NCT06429033 | COMPLETED | PHASE1
8 Participants

Purified Exosome Product (PEP) Injected Into the Hypodermis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-04-14
Completion: 2025-12-17
Conditions
Safety
Interventions
DRUG
No Results Yet
NCT06428396 | RECRUITING | PHASE2
120 Participants

Study of Belzutifan (MK-6482) Plus Fulvestrant for ER+/HER2- Metastatic Breast Cancer (MK-6482-029/LITESPARK-029)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-11-27
Completion: 2027-05-05
Conditions
Metastatic Breast Cancer
Interventions
DRUG
No Results Yet
NCT06414889 | RECRUITING | PHASE1
4 Participants

Protocol Title: Safety and Feasibility of Autologous CD34+ Hematopoietic Stem Cells Mobilization and Apheresis in Participants With RUNX1 Familial Platelet Disorder

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-05-20
Completion: 2027-06-30
Conditions
RUNX1 Familial Platelet Disorder
Interventions
DRUG PROCEDURE
No Results Yet
NCT06405932 | COMPLETED | NA
1691 Participants

Study of the Intervention Effect of Self-help Training Camps in Promoting Mental Health Among Perinatal Women

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-09-11
Completion: 2025-09-01
Conditions
Mental Health Perinatal Depression
Interventions
COMBINATION_PRODUCT
No Results Yet
NCT06397144 | WITHDRAWN | PHASE1
0 Participants

A Study on 2 Different Combination Tablets of Nirmatrelvir Plus Ritonavir to Compare Them With Marketed Paxlovid in Healthy Participants

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-08-15
Completion: 2025-12-09
Conditions
Biological Availability Healthy Participants
Interventions
DRUG
No Results Yet
NCT06395753 | RECRUITING | PHASE2
66 Participants

A Dose Finding Study of Debio 4228 in Participants With Advanced Prostate Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-05-23
Completion: 2026-12-31
Conditions
Prostate Cancer
Interventions
DRUG
No Results Yet
NCT06395441 | RECRUITING | PHASE3
160 Participants

Wisconsin Ginseng for Decreasing Cancer Related Fatigue

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-08-01
Completion: 2026-11-30
Conditions
Malignant Solid Neoplasm
Interventions
DIETARY_SUPPLEMENT DRUG OTHER
No Results Yet
NCT06391775 | TERMINATED | PHASE1/PHASE2
21 Participants

Trial to Assess the Safety and Preliminary Efficacy of GEN1055 on Malignant Solid Tumors as Monotherapy and as Combination Therapy

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-05-14
Completion: 2025-11-20
Conditions
Malignant Solid Tumor
Interventions
BIOLOGICAL DRUG
No Results Yet
NCT06388733 | RECRUITING | PHASE3
450 Participants

A Study Comparing Niraparib With Temozolomide in Adult Participants With Newly-diagnosed, MGMT Unmethylated Glioblastoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-06-19
Completion: 2027-12-31
Conditions
Glioblastoma GBM Brain Neoplasms, Adult, Malignant Brain Tumor
Interventions
DRUG
No Results Yet
NCT06388148 | RECRUITING | NA
286 Participants

Endovascular Treatment for eXtra-Large Ischemic Stroke

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-06-16
Completion: 2026-10-31
Conditions
Stroke, Acute Ischemic
Interventions
DRUG PROCEDURE
No Results Yet
NCT06387979 | SUSPENDED
285 Participants

Advanced Development of Desorption Electrospray Ionization Mass Spectrometry for Intraoperative Molecular Diagnosis of Brain Cancer Using Pathology Biopsies

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2020-10-26
Completion: 2026-10-15
Conditions
Glioma
Interventions
OTHER
No Results Yet
NCT06380738 | RECRUITING
250 Participants

Real-World Clinical Experience of Patients With Metastatic Castration-Resistant Prostate Cancer Treated With Olaparib + Abiraterone (PROceed)

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2024-02-14
Completion: 2027-01-31
Conditions
Metastatic Castration-resistant Prostate Cancer
No Results Yet
NCT06380530 | RECRUITING | NA
100 Participants

Advanced Surgical Simulation Processes in the Correction of Skeletal Defects and Deformities

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-10-31
Completion: 2028-05-31
Conditions
Musculoskeletal Deformity Musculoskeletal Abnormalities Musculoskeletal Disorder
Interventions
PROCEDURE
No Results Yet
NCT06380075 | RECRUITING | NA
50 Participants

COmparison of Clarus and Optos Ultrawide Field Imaging Systems for Inherited Retinal Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-08-29
Completion: 2026-12-31
Conditions
Retinal Disease
Interventions
DEVICE
No Results Yet
NCT06378866 | RECRUITING | PHASE2
532 Participants

Stereotactic Body Radiation Therapy Plus Immediate or Delayed Androgen Receptor Pathway Inhibitor and Androgen Deprivation Therapy or Salvage Radiation Therapy for the Treatment of Prostate Cancer, DIVINE Trial

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-06-03
Completion: 2029-05-31
Conditions
Recurrent Castration-Sensitive Prostate Carcinoma Recurrent Prostate Cancer Castration-resistant Prostate Cancer Biochemically Recurrent Prostate Carcinoma
Interventions
DRUG PROCEDURE OTHER RADIATION
No Results Yet
NCT06377527 | RECRUITING
2000 Participants

Establishing a Tumor Registry of Patients With Mesonephric-like Adenocarcinoma (MLA)

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2024-07-10
Completion: 2035-12-28
Conditions
Mesonephric-like Adenocarcinoma
No Results Yet
NCT06374394 | COMPLETED | PHASE3
841 Participants

A Study on the Immune Response and Safety of a Vaccine Against Respiratory Syncytial Virus (RSV) When Given Alone and Together With a COVID-19 mRNA Vaccine in Adults Aged 50 Years and Above

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-04-29
Completion: 2024-11-01
Conditions
Respiratory Syncytial Virus Infections
Interventions
BIOLOGICAL
Results Available
NCT06361550 | RECRUITING | NA
200 Participants

Nutritional Status Assessment and Dietary Recommendations Program (VENREDI)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2023-11-02
Completion: 2026-06-30
Conditions
Adherence to the Mediterranean Diet
Interventions
OTHER
No Results Yet
NCT06360406 | RECRUITING
200 Participants

Real-World Treatment Study of Koselugo (Selumetinib)

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2024-06-15
Completion: 2031-09-30
Conditions
Neurofibromatosis 1 Neurofibroma, Plexiform
No Results Yet
NCT06346197 | RECRUITING | PHASE3
132 Participants

Combination of Immune Checkpoint in Locally Advanced or Metastatic MSI/dMMR Esogastric Adenocarcinomas

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-12-08
Completion: 2028-05-15
Conditions
Gastric Cancer MSI-H Metastatic Cancer Advanced Cancer
Interventions
DRUG
No Results Yet
NCT06332534 | RECRUITING | PHASE3
110 Participants

Crohn's Disease: Efficacy, Safety, and Pharmacokinetics of Upadacitinib in Pediatric Subjects With Moderately to Severely Active Crohn's Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-07-26
Completion: 2027-06-30
Conditions
Crohn's Disease
Interventions
DRUG
No Results Yet
NCT06331468 | RECRUITING | PHASE2
20 Participants

Hypofractionated Radiochemotherapy

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-06-26
Completion: 2026-07-01
Conditions
Uterine Cervix Cancer
Interventions
DRUG RADIATION
No Results Yet
NCT06322342 | COMPLETED | PHASE2
18 Participants

Phase 2 Ascending Dose Safety and Efficacy Study of RVP-001, a Manganese-based MRI Contrast Agent

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-08-15
Completion: 2025-12-19
Conditions
Neoplasia Central Nervous System (CNS) Lesions Brain Metastases Brain Neoplasms Brain Neoplasms, Benign Brain Tumor, Primary Brain Tumor, Recurrent Brain Tumors Brain Cancer Brain Tumor Brain Neoplasm, Primary Multiple Sclerosis Multiple Sclerosis Brain Lesion Neurofibroma Acoustic Neuroma CNS Tumor CNS Lesion CNS Metastases CNS Cancer CNS Lymphoma Von Hippel Lindau Meningioma Glioma Schwannomas Neuroinflammation
Interventions
DRUG
No Results Yet
NCT06315010 | RECRUITING | PHASE2
20 Participants

REPotrectinib in ROS1-positive Non-small Cell Lung Cancer Patients With Active Brain mEtastasis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-06-27
Completion: 2027-03-31
Conditions
NSCLC Brain Metastases ROS1 Gene Rearrangement
Interventions
DRUG
No Results Yet
NCT06313398 | RECRUITING | EARLY_PHASE1
100 Participants

Determination of Red Cell Survival in Sickle Cell Disease and Other Hemoglobinopathies Using Biotin Labeling

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-05-17
Completion: 2029-05-01
Conditions
Sickle Cell Disease Thalassemia Hemoglobinopathy
Interventions
BIOLOGICAL
No Results Yet
NCT06311500 | COMPLETED | PHASE1/PHASE2
30 Participants

Sleep Health Enhancement in Midlife Adults

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-02-13
Completion: 2025-11-19
Conditions
Sleep Health Midlife Adults
Interventions
BEHAVIORAL
No Results Yet
NCT06311383 | COMPLETED
2610 Participants

A Non-interventional Study for Women With HR-positive, HER2-negative Locally Advanced or Metastatic Breast Cancer to Evaluate the Real-world Effectiveness of Treatment Algorithms Beginning With Ribociclib + AI/FUL, or With Endocrine Therapy or Chemotherapy as First Line Treatment

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2017-10-09
Completion: 2025-02-16
Conditions
Breast Cancer
Interventions
DRUG
No Results Yet
NCT06307470 | COMPLETED | NA
43 Participants

Nurse-led Mind-body Intervention on Sexual Health for Breast Cancer Survivors

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-10-15
Completion: 2025-11-30
Conditions
Women's Health: Neoplasm of Breast Menopause, Premature Body Image Sexual Dysfunction Cancer, Breast
Interventions
BEHAVIORAL
No Results Yet
NCT06286046 | NOT_YET_RECRUITING | PHASE2
40 Participants

A Study of Mitapivat in Participants With Sickle Cell Disease and Nephropathy

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2026-03-31
Completion: 2027-05-31
Conditions
Sickle Cell Disease Nephropathy
Interventions
DRUG
No Results Yet
NCT06271616 | RECRUITING | PHASE2
40 Participants

Ibrutinib for the Prevention of Chronic Graft-Versus-Host Disease in Patients Undergoing Donor Stem Cell Transplant

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-12-13
Completion: 2027-06-30
Conditions
Chronic Graft Versus Host Disease Hematopoietic and Lymphatic System Neoplasm
Interventions
PROCEDURE DRUG
No Results Yet
NCT06263543 | RECRUITING | PHASE2
75 Participants

Sequencing Antibody Drug Conjugates in ER+/HER2 LOW/ULTRA LOW MBC

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-06-17
Completion: 2026-06-30
Conditions
Advanced Breast Cancer Metastatic Breast Cancer Breast Cancer Hormone-receptor-positive Breast Cancer Human Epidermal Growth Factor 2 Low Breast Cancer
Interventions
DRUG
No Results Yet
NCT06263270 | COMPLETED | PHASE1
19 Participants

Evaluation of CYT-108, A Recombinant Protease Inhibitor, for Treatment of Mild To Moderate Primary Osteoarthritis Of The Knee

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-06-01
Completion: 2025-03-15
Conditions
Osteoarthritis, Knee Osteoarthritis
Interventions
BIOLOGICAL OTHER
No Results Yet
NCT06252753 | RECRUITING
4490 Participants

Observational Study Protocol: LIVER-R

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2023-03-16
Completion: 2030-12-30
Conditions
Hepatobiliary Cancers
Interventions
OTHER
No Results Yet
NCT06241313 | RECRUITING | PHASE3
1300 Participants

Study of Oral Atogepant Tablets to Assess Safety and Efficacy in Adult Participants With Migraine

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-03-25
Completion: 2025-07-07
Conditions
Migraine
Interventions
DRUG
No Results Yet
NCT06212570 | NOT_YET_RECRUITING | NA
12 Participants

KeyScope Study in Uganda

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2026-04-01
Completion: 2027-03-30
Conditions
Abdominal Neoplasm
Interventions
DEVICE
No Results Yet
NCT06200207 | RECRUITING | PHASE3
680 Participants

A Research Study Looking Into How Ziltivekimab Works Compared to Placebo in Participants With Heart Failure and Inflammation

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-04-01
Completion: 2026-10-05
Conditions
Heart Failure Systemic Inflammation
Interventions
DRUG
No Results Yet
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