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Clinical Trials

Showing trials with last updates posted in 2025.

NCT06387979 | SUSPENDED
285 Participants

Advanced Development of Desorption Electrospray Ionization Mass Spectrometry for Intraoperative Molecular Diagnosis of Brain Cancer Using Pathology Biopsies

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2020-10-26
Completion: 2026-10-15
Conditions
Glioma
Interventions
OTHER
No Results Yet
NCT06380738 | RECRUITING
250 Participants

Real-World Clinical Experience of Patients With Metastatic Castration-Resistant Prostate Cancer Treated With Olaparib + Abiraterone (PROceed)

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2024-02-14
Completion: 2027-01-31
Conditions
Metastatic Castration-resistant Prostate Cancer
No Results Yet
NCT06380530 | RECRUITING | NA
100 Participants

Advanced Surgical Simulation Processes in the Correction of Skeletal Defects and Deformities

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-10-31
Completion: 2028-05-31
Conditions
Musculoskeletal Deformity Musculoskeletal Abnormalities Musculoskeletal Disorder
Interventions
PROCEDURE
No Results Yet
NCT06380075 | RECRUITING | NA
50 Participants

COmparison of Clarus and Optos Ultrawide Field Imaging Systems for Inherited Retinal Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-08-29
Completion: 2026-12-31
Conditions
Retinal Disease
Interventions
DEVICE
No Results Yet
NCT06378866 | RECRUITING | PHASE2
532 Participants

Stereotactic Body Radiation Therapy Plus Immediate or Delayed Androgen Receptor Pathway Inhibitor and Androgen Deprivation Therapy or Salvage Radiation Therapy for the Treatment of Prostate Cancer, DIVINE Trial

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-06-03
Completion: 2029-05-31
Conditions
Recurrent Castration-Sensitive Prostate Carcinoma Recurrent Prostate Cancer Castration-resistant Prostate Cancer Biochemically Recurrent Prostate Carcinoma
Interventions
DRUG PROCEDURE OTHER RADIATION
No Results Yet
NCT06377527 | RECRUITING
2000 Participants

Establishing a Tumor Registry of Patients With Mesonephric-like Adenocarcinoma (MLA)

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2024-07-10
Completion: 2035-12-28
Conditions
Mesonephric-like Adenocarcinoma
No Results Yet
NCT06374394 | COMPLETED | PHASE3
841 Participants

A Study on the Immune Response and Safety of a Vaccine Against Respiratory Syncytial Virus (RSV) When Given Alone and Together With a COVID-19 mRNA Vaccine in Adults Aged 50 Years and Above

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-04-29
Completion: 2024-11-01
Conditions
Respiratory Syncytial Virus Infections
Interventions
BIOLOGICAL
Results Available
NCT06361550 | RECRUITING | NA
200 Participants

Nutritional Status Assessment and Dietary Recommendations Program (VENREDI)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2023-11-02
Completion: 2026-06-30
Conditions
Adherence to the Mediterranean Diet
Interventions
OTHER
No Results Yet
NCT06360406 | RECRUITING
200 Participants

Real-World Treatment Study of Koselugo (Selumetinib)

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2024-06-15
Completion: 2031-09-30
Conditions
Neurofibromatosis 1 Neurofibroma, Plexiform
No Results Yet
NCT06346197 | RECRUITING | PHASE3
132 Participants

Combination of Immune Checkpoint in Locally Advanced or Metastatic MSI/dMMR Esogastric Adenocarcinomas

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-12-08
Completion: 2028-05-15
Conditions
Gastric Cancer MSI-H Metastatic Cancer Advanced Cancer
Interventions
DRUG
No Results Yet
NCT06337318 | RECRUITING | PHASE3
600 Participants

Comparing Rituximab and Mosunetuzumab Drug Treatments for People With Low Tumor Burden Follicular Lymphoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-10-23
Completion: 2032-03-31
Conditions
Classic Follicular Lymphoma Follicular Lymphoma With Unusual Cytological Features
Interventions
PROCEDURE BIOLOGICAL
No Results Yet
NCT06332534 | RECRUITING | PHASE3
110 Participants

Crohn's Disease: Efficacy, Safety, and Pharmacokinetics of Upadacitinib in Pediatric Subjects With Moderately to Severely Active Crohn's Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-07-26
Completion: 2027-06-30
Conditions
Crohn's Disease
Interventions
DRUG
No Results Yet
NCT06331468 | RECRUITING | PHASE2
20 Participants

Hypofractionated Radiochemotherapy

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-06-26
Completion: 2026-07-01
Conditions
Uterine Cervix Cancer
Interventions
DRUG RADIATION
No Results Yet
NCT06325683 | RECRUITING | PHASE2
184 Participants

Anti-Lag-3 (Relatlimab) and Anti-PD-1 Blockade (Nivolumab) Versus Standard of Care (Lomustine) for the Treatment of Patients With Recurrent Glioblastoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-11-08
Completion: 2028-07-15
Conditions
Progressive Glioblastoma Recurrent Glioblastoma
Interventions
PROCEDURE DRUG BIOLOGICAL
No Results Yet
NCT06322342 | COMPLETED | PHASE2
18 Participants

Phase 2 Ascending Dose Safety and Efficacy Study of RVP-001, a Manganese-based MRI Contrast Agent

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-08-15
Completion: 2025-12-19
Conditions
Neoplasia Central Nervous System (CNS) Lesions Brain Metastases Brain Neoplasms Brain Neoplasms, Benign Brain Tumor, Primary Brain Tumor, Recurrent Brain Tumors Brain Cancer Brain Tumor Brain Neoplasm, Primary Multiple Sclerosis Multiple Sclerosis Brain Lesion Neurofibroma Acoustic Neuroma CNS Tumor CNS Lesion CNS Metastases CNS Cancer CNS Lymphoma Von Hippel Lindau Meningioma Glioma Schwannomas Neuroinflammation
Interventions
DRUG
No Results Yet
NCT06317662 | RECRUITING | PHASE2
153 Participants

Testing the Addition of the Anti-cancer Drug Venetoclax and/or the Anti-cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed KMT2A-rearranged or KMT2A-non-rearranged Leukemia

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-06-05
Completion: 2028-12-31
Conditions
Acute Leukemia of Ambiguous Lineage B Acute Lymphoblastic Leukemia
Interventions
DRUG PROCEDURE BIOLOGICAL
No Results Yet
NCT06315010 | RECRUITING | PHASE2
20 Participants

REPotrectinib in ROS1-positive Non-small Cell Lung Cancer Patients With Active Brain mEtastasis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-06-27
Completion: 2027-03-31
Conditions
NSCLC Brain Metastases ROS1 Gene Rearrangement
Interventions
DRUG
No Results Yet
NCT06313398 | RECRUITING | EARLY_PHASE1
100 Participants

Determination of Red Cell Survival in Sickle Cell Disease and Other Hemoglobinopathies Using Biotin Labeling

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-05-17
Completion: 2029-05-01
Conditions
Sickle Cell Disease Thalassemia Hemoglobinopathy
Interventions
BIOLOGICAL
No Results Yet
NCT06311500 | COMPLETED | PHASE1/PHASE2
30 Participants

Sleep Health Enhancement in Midlife Adults

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-02-13
Completion: 2025-11-19
Conditions
Sleep Health Midlife Adults
Interventions
BEHAVIORAL
No Results Yet
NCT06311383 | COMPLETED
2610 Participants

A Non-interventional Study for Women With HR-positive, HER2-negative Locally Advanced or Metastatic Breast Cancer to Evaluate the Real-world Effectiveness of Treatment Algorithms Beginning With Ribociclib + AI/FUL, or With Endocrine Therapy or Chemotherapy as First Line Treatment

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2017-10-09
Completion: 2025-02-16
Conditions
Breast Cancer
Interventions
DRUG
No Results Yet
NCT06311227 | RECRUITING | PHASE2
20 Participants

Venetoclax for the Treatment of Patients With Relapsed Hairy Cell Leukemia

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-12-16
Completion: 2027-05-20
Conditions
Recurrent Hairy Cell Leukemia Recurrent Hairy Cell Leukemia Variant
Interventions
PROCEDURE DRUG
No Results Yet
NCT06311214 | RECRUITING | PHASE2
500 Participants

Personalized Antibody-Drug Conjugate Therapy Based on RNA and Protein Testing for the Treatment of Advanced or Metastatic Solid Tumors (The ADC MATCH Screening and Treatment Trial)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-03-18
Completion: 2028-03-31
Conditions
Advanced Malignant Solid Neoplasm Metastatic Malignant Solid Neoplasm
Interventions
PROCEDURE OTHER DRUG BIOLOGICAL
No Results Yet
NCT06311188 | NOT_YET_RECRUITING | NA
90 Participants

Exploring PTSD Symptoms, Barriers and Facilitators to Mindfulness

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-12-30
Completion: 2026-01-26
Conditions
Stress Trauma PTSD HPA
Interventions
BEHAVIORAL
No Results Yet
NCT06307470 | COMPLETED | NA
43 Participants

Nurse-led Mind-body Intervention on Sexual Health for Breast Cancer Survivors

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-10-15
Completion: 2025-11-30
Conditions
Women's Health: Neoplasm of Breast Menopause, Premature Body Image Sexual Dysfunction Cancer, Breast
Interventions
BEHAVIORAL
No Results Yet
NCT06303193 | NOT_YET_RECRUITING | PHASE1/PHASE2
160 Participants

Pacritinib, a Kinase Inhibitor of CSF1R, IRAK1, JAK2, and FLT3, in Adults and Pediatric Participants 12 Years of Age or Older With Myelodysplastic Syndromes or Myelodysplastic/Myeloproliferative Neoplasms

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-12-30
Completion: 2030-01-01
Conditions
Myelodysplastic Syndromes
Interventions
DRUG
No Results Yet
NCT06286046 | NOT_YET_RECRUITING | PHASE2
40 Participants

A Study of Mitapivat in Participants With Sickle Cell Disease and Nephropathy

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2026-03-31
Completion: 2027-05-31
Conditions
Sickle Cell Disease Nephropathy
Interventions
DRUG
No Results Yet
NCT06280820 | ENROLLING_BY_INVITATION
2000 Participants

Multi-Scale Analysis of Phenotypes in Heart Failure (MAP-HEART)

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2025-12-30
Completion: 2028-04-30
Conditions
Heart Failure
No Results Yet
NCT06274749 | RECRUITING | NA
180 Participants

Effects of Urolithin A Supplementation on Glucose Metabolism in Healthy Adults 55 >= Years Old: A Randomized Triple-Masked Controlled Clinical Trial

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-12-30
Completion: 2027-03-31
Conditions
Healthy Volunteer
Interventions
DIETARY_SUPPLEMENT
No Results Yet
NCT06271616 | RECRUITING | PHASE2
40 Participants

Ibrutinib for the Prevention of Chronic Graft-Versus-Host Disease in Patients Undergoing Donor Stem Cell Transplant

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-12-13
Completion: 2027-06-30
Conditions
Chronic Graft Versus Host Disease Hematopoietic and Lymphatic System Neoplasm
Interventions
PROCEDURE DRUG
No Results Yet
NCT06269627 | RECRUITING | PHASE4
48 Participants

Temporally-Resolved Electrophysiology of Acamprosate Treatment of Alcohol Use Disorder

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-05-07
Completion: 2025-12-31
Conditions
Alcohol Use Disorder
Interventions
DRUG OTHER
No Results Yet
NCT06263543 | RECRUITING | PHASE2
75 Participants

Sequencing Antibody Drug Conjugates in ER+/HER2 LOW/ULTRA LOW MBC

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-06-17
Completion: 2026-06-30
Conditions
Advanced Breast Cancer Metastatic Breast Cancer Breast Cancer Hormone-receptor-positive Breast Cancer Human Epidermal Growth Factor 2 Low Breast Cancer
Interventions
DRUG
No Results Yet
NCT06263270 | COMPLETED | PHASE1
19 Participants

Evaluation of CYT-108, A Recombinant Protease Inhibitor, for Treatment of Mild To Moderate Primary Osteoarthritis Of The Knee

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-06-01
Completion: 2025-03-15
Conditions
Osteoarthritis, Knee Osteoarthritis
Interventions
BIOLOGICAL OTHER
No Results Yet
NCT06252753 | RECRUITING
4490 Participants

Observational Study Protocol: LIVER-R

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2023-03-16
Completion: 2030-12-30
Conditions
Hepatobiliary Cancers
Interventions
OTHER
No Results Yet
NCT06241313 | RECRUITING | PHASE3
1300 Participants

Study of Oral Atogepant Tablets to Assess Safety and Efficacy in Adult Participants With Migraine

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-03-25
Completion: 2025-07-07
Conditions
Migraine
Interventions
DRUG
No Results Yet
NCT06212570 | NOT_YET_RECRUITING | NA
12 Participants

KeyScope Study in Uganda

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2026-04-01
Completion: 2027-03-30
Conditions
Abdominal Neoplasm
Interventions
DEVICE
No Results Yet
NCT06206746 | RECRUITING | NA
195 Participants

The REBALANCE Study - a Prospective, Multicenter, Randomized, Pivotal Study of the May Health System

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-03-25
Completion: 2026-06-30
Conditions
Polycystic Ovary Syndrome Infertility, Female
Interventions
DEVICE
No Results Yet
NCT06203600 | RECRUITING | PHASE2/PHASE3
224 Participants

Adding Nivolumab to Usual Treatment for People With Advanced Stomach or Esophageal Cancer, PARAMUNE Trial

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-06-24
Completion: 2027-10-31
Conditions
Advanced Esophageal Adenocarcinoma Advanced Gastric Adenocarcinoma Advanced Gastroesophageal Junction Adenocarcinoma Clinical Stage II Esophageal Adenocarcinoma AJCC v8 Clinical Stage III Esophageal Adenocarcinoma AJCC v8 Clinical Stage III Gastric Cancer AJCC v8 Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8 Clinical Stage IV Esophageal Adenocarcinoma AJCC v8 Clinical Stage IV Gastric Cancer AJCC v8 Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8 Metastatic Esophageal Adenocarcinoma Metastatic Gastric Adenocarcinoma Metastatic Gastroesophageal Junction Adenocarcinoma Unresectable Esophageal Adenocarcinoma Unresectable Gastric Adenocarcinoma Unresectable Gastroesophageal Junction Adenocarcinoma
Interventions
PROCEDURE BIOLOGICAL DRUG OTHER
No Results Yet
NCT06200207 | RECRUITING | PHASE3
680 Participants

A Research Study Looking Into How Ziltivekimab Works Compared to Placebo in Participants With Heart Failure and Inflammation

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-04-01
Completion: 2026-10-05
Conditions
Heart Failure Systemic Inflammation
Interventions
DRUG
No Results Yet
NCT06196463 | COMPLETED | NA
11 Participants

Erector Spinae Plane (ESP) Block in Juvenile Idiopathic Scoliosis Surgery

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2023-09-11
Completion: 2024-12-11
Conditions
Juvenile Idiopathic Scoliosis, Multiple Sites in Spine
Interventions
PROCEDURE
No Results Yet
NCT06195306 | RECRUITING | PHASE2
66 Participants

Low Dose Tamoxifen With or Without Omega-3 Fatty Acids for Breast Cancer Risk Reduction

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-07-28
Completion: 2027-01-01
Conditions
Breast Atypical Hyperplasia Breast Carcinoma Breast Ductal Carcinoma In Situ Breast Lobular Carcinoma In Situ
Interventions
PROCEDURE DRUG OTHER
No Results Yet
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