Clinical Trials
Showing trials with last updates posted in 2025.
315
Participants
A Study to Investigate the Efficacy and Safety of Crizanlizumab (5 mg/kg) Compared With Placebo in Adolescent and Adult Sickle Cell Disease Patients Who Experience Frequent Vaso-Occlusive Crises (SPARKLE)
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2024-10-24
Completion:
2029-03-23
Conditions
Sickle Cell Disease
Interventions
BIOLOGICAL
DRUG
No Results Yet
220
Participants
A Clinical Study of MK-2870 Alone or With Other Treatments to Treat Gastrointestinal Cancers (MK-9999-02A)
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2024-06-20
Completion:
2029-10-16
Conditions
Colorectal Cancer
Pancreatic Ductal Adenocarcinoma
Biliary Tract Cancer
Interventions
BIOLOGICAL
DRUG
No Results Yet
40
Participants
Fasenra Pediatric Japan Post-Marketing Study(PMS)
Study Type:
OBSERVATIONAL
Last Updated:
2025-12-24
Start Date:
2024-07-16
Completion:
2027-03-17
Conditions
Bronchial Asthma
No Results Yet
851
Participants
Pembrolizumab With or Without Maintenance Sacituzumab Tirumotecan (Sac-TMT; MK-2870) in Metastatic Squamous Non-small Cell Lung Cancer (NSCLC) [MK-2870-023]
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2024-06-10
Completion:
2029-01-12
Conditions
Non-small Cell Lung Cancer
NSCLC
Interventions
BIOLOGICAL
DRUG
No Results Yet
35
Participants
Prosthetic Performance Enhancement Trial
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2025-06-26
Completion:
2026-11-30
Conditions
Amputation
Lower Limb Amputation Below Knee (Injury)
Lower Limb Amputation Above Knee (Injury)
Lower Limb Amputation at Ankle (Injury)
Lower Limb Amputation Knee
Lower Limb Amputation at Hip (Injury)
Interventions
OTHER
No Results Yet
24
Participants
Regional Lipolysis and Adipocyte Lipolysis Protein Stimulation
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2024-01-01
Completion:
2027-04-01
Conditions
Obesity
Interventions
DRUG
No Results Yet
928
Participants
Little Cigar and Cigarillo Warnings for Youth
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2024-07-18
Completion:
2024-11-25
Conditions
Little Cigars and Cigarillos (LCC) Use
Interventions
BEHAVIORAL
45
Participants
A Study Comparing Abemaciclib Plus Temozolomide to Temozolomide Monotherapy in Children and Young Adults With High-grade Glioma Following Radiotherapy
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2024-10-25
Completion:
2027-11-30
Conditions
Glioma
Interventions
DRUG
No Results Yet
60
Participants
Efficacy and Safety of Local Glucocorticoids for the Treatment of Acute Radiation-Induced Intestinal Injury
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2024-08-01
Completion:
2026-12-31
Conditions
Radiation-Induced Intestinal Injury
Interventions
DRUG
No Results Yet
100
Participants
Detection of Aortic Stenosis With Smartphone Auscultation Using Machine Learning (HEARTBEAT-Pilot)
Study Type:
OBSERVATIONAL
Last Updated:
2025-12-24
Start Date:
2023-03-09
Completion:
2024-05-22
Conditions
Aortic Valve Stenosis
Interventions
DIAGNOSTIC_TEST
No Results Yet
40
Participants
Assessment of Fall Risks and Subject-specific Training for Fall Reduction
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2025-12-31
Completion:
2029-04-30
Conditions
Fall Risk
Interventions
DEVICE
No Results Yet
60
Participants
THRIVE Well Cancer FDTN/Exercise_Creatine Supplementation
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2024-10-29
Completion:
2028-05-31
Conditions
Breast Cancer
Breast Cancer Female
Muscle Weakness
Interventions
DIETARY_SUPPLEMENT
No Results Yet
90
Participants
Substudy 01A: Zilovertamab Vedotin in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01A/LIGHTBEAM-U01)
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2024-08-16
Completion:
2029-03-31
Conditions
B-cell Acute Lymphoblastic Leukemia
Diffuse Large B-cell Lymphoma
Burkitt Lymphoma
Neuroblastoma
Ewing Sarcoma
Interventions
BIOLOGICAL
No Results Yet
132
Participants
Supporting Oral Pre-exposure Prophylaxis Decision Making Among Pregnant Women in Lilongwe, Malawi
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2024-08-06
Completion:
2025-02-07
Conditions
HIV Prevention
Interventions
BEHAVIORAL
1530
Participants
Sacituzumab Tirumotecan (MK-2870) Plus Pembrolizumab Versus TPC in TNBC Who Did Not Achieve pCR (MK-2870-012)
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2024-06-24
Completion:
2030-12-16
Conditions
Triple-Negative Breast Cancer
Interventions
BIOLOGICAL
DRUG
No Results Yet
40
Participants
Nomogram for Prediction of Alveolo-arterial Gradient During One-lung Ventilation
Study Type:
OBSERVATIONAL
Last Updated:
2025-12-24
Start Date:
2024-06-01
Completion:
2024-11-01
Conditions
One-lung Ventilation
No Results Yet
80
Participants
ALS Phase II Study of NX210c
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2024-10-25
Completion:
2026-02-01
Conditions
Amyotrophic Lateral Sclerosis
Interventions
DRUG
No Results Yet
500
Participants
Observational Study of Neurofilament Light Chain (NfL) as a Biomarker in Asymptomatic Carriers of the Transthyretin (TTR) Variants and Patients With Hereditary Transthyretin-mediated (hATTR) Amyloidosis With Polyneuropathy
Study Type:
OBSERVATIONAL
Last Updated:
2025-12-24
Start Date:
2024-04-25
Completion:
2027-12-01
Conditions
Hereditary Amyloidosis, Transthyretin-Related
Asymptomatic Carrier State
Interventions
OTHER
No Results Yet
12
Participants
A Study of the Safety, Dosing, and Delivery of NEO100 in Patients With Pediatric Brain Tumors
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2025-12-31
Completion:
2026-10-31
Conditions
Pediatric Tumor of CNS
Pediatric Tumor of Brain
Diffuse Midline Glioma, H3 K27M-Mutant
Pediatric Tumor of Brain Stem
Pineocytoma
Choroid Plexus Carcinoma, Childhood
Spinal Cord Tumor
High Grade Glioma
Interventions
DRUG
No Results Yet
450
Participants
A Study to Evaluate Sacituzumab Tirumotecan (MK-2870) in Advanced/Metastatic Gastroesophageal Adenocarcinoma (MK-2870-015)
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2024-05-03
Completion:
2027-01-04
Conditions
Gastroesophageal Cancer
Interventions
BIOLOGICAL
DRUG
No Results Yet
220
Participants
Substudy 01A: Safety and Efficacy of Opevesostat (MK-5684)-Based Treatment Combinations or Opevesostat Alone in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-5684-01A)
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2024-05-20
Completion:
2029-01-15
Conditions
Prostatic Neoplasms, Castration-Resistant
Interventions
DRUG
No Results Yet
60
Participants
Risk of Reactivation of Occult Hepatitis B in Cancer Patients During Immunotherapy.
Study Type:
OBSERVATIONAL
Last Updated:
2025-12-24
Start Date:
2022-06-06
Completion:
2026-05-31
Conditions
Occult Hepatitis B Infection in Cancer Patients
Interventions
OTHER
No Results Yet
30
Participants
Seizure Rescue Medication (RM) as Part of a Comprehensive Epilepsy Self-management Package of Care
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2024-03-05
Completion:
2026-01-01
Conditions
Epilepsy
Interventions
BEHAVIORAL
DRUG
No Results Yet
378
Participants
ITAKOS - Italian Observation, Multicenter, Prospective Study of Ofatumumab in RRMS Patients
Study Type:
OBSERVATIONAL
Last Updated:
2025-12-24
Start Date:
2024-07-30
Completion:
2026-06-30
Conditions
Multiple Sclerosis, Relapsing-Remitting
Interventions
DRUG
No Results Yet
76
Participants
A Phase 1 Study of AJ1-11095 in Patients With Primary Myelofibrosis (PMF), Post-Polycythemia Vera Myelofibrosis (PPV-MF), or Post-Essential Thrombocythemia Myelofibrosis (PET-MF) Who Have Been Failed by a Type I JAK2 Inhibitor (JAK2i)
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2024-10-23
Completion:
2026-10-15
Conditions
Primary Myelofibrosis
Post-Essential Thrombocythemia Myelofibrosis
Post-Polycythemia Vera Myelofibrosis
PMF
PPV-MF
PET-MF
Interventions
DRUG
No Results Yet
589
Participants
Identification of Novel High Quality Methylated DNA Markers in Renal Tumors: Whole Methylome Discovery, Tissue Validation, and Feasibility Testing In Blood and Urine, The INQUIRE Study
Study Type:
OBSERVATIONAL
Last Updated:
2025-12-24
Start Date:
2018-06-27
Completion:
2027-01-31
Conditions
Chromophobe Renal Cell Carcinoma
Clear Cell Papillary Renal Tumor
Clear Cell Renal Cell Carcinoma
Kidney Oncocytoma
Papillary Renal Cell Carcinoma
Urothelial Carcinoma
Interventions
OTHER
No Results Yet
150
Participants
Cadisegliatin as Adjunctive Therapy to Insulin in Participants With Type 1 Diabetes
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2024-06-14
Completion:
2026-09-30
Conditions
Diabetes Mellitus, Type 1
Interventions
DRUG
No Results Yet
160
Participants
A Study of DM919 Alone and in Combination With Pembrolizumab in Advanced Solid Tumors
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2024-04-09
Completion:
2026-03-01
Conditions
Advanced Solid Tumor
Interventions
DRUG
No Results Yet
96
Participants
Pericapsular Nerve Group Block vs Supra Inguinal Fascia Iliaca Compartment Block
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2024-05-01
Completion:
2025-11-01
Conditions
Pain, Postoperative
Interventions
PROCEDURE
No Results Yet
178
Participants
A Study to Test Whether BI 764524 Helps People With an Eye Condition Called Diabetic Retinopathy
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2024-05-15
Completion:
2027-04-30
Conditions
Diabetic Retinopathy
Interventions
DRUG
No Results Yet
149
Participants
Effect of Vericiguat on Acute Coronary Syndrome( ACS）Patients With Ejection Fraction <45%
Study Type:
OBSERVATIONAL
Last Updated:
2025-12-24
Start Date:
2024-01-31
Completion:
2025-10-01
Conditions
Acute Coronary Syndrome
Heart Failure With Reduced Ejection Fraction
No Results Yet
140
Participants
A Study to Assess Adverse Events, and How Intravenously (IV) Infused ABBV-969 Moves Through the Bodies of Adult Participants With Metastatic Castration-Resistant Prostate Cancer
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2024-03-08
Completion:
2027-05-31
Conditions
Metastatic Castration-Resistant Prostate Cancer
Interventions
DRUG
No Results Yet
1200
Participants
A Study of Sacituzumab Tirumotecan (MK-2870) as a Single Agent and in Combination With Pembrolizumab (MK-3475) Versus Treatment of Physician's Choice in Participants With HR+/HER2- Unresectable Locally Advanced or Metastatic Breast Cancer (MK-2870-010)
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2024-04-14
Completion:
2027-07-11
Conditions
Breast Neoplasms
Interventions
DRUG
BIOLOGICAL
No Results Yet
780
Participants
A Study to Assess Efficacy and Safety of Pembrolizumab With or Without Sacituzumab Tirumotecan (MK- 2870) in Adult Participants With Resectable Non Small Cell Lung Cancer (NSCLC) Not Achieving Pathological Complete Response (pCR) (MK-2870-019)
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2024-04-03
Completion:
2034-02-21
Conditions
Non Small Cell Lung Cancer
Interventions
BIOLOGICAL
DRUG
No Results Yet
230
Participants
A Clinical Study of Intismeran Autogene (V940) Treatment and Pembrolizumab in People With Bladder Cancer (V940-005/INTerpath-005)
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2024-03-28
Completion:
2027-04-23
Conditions
Bladder Cancer
Interventions
BIOLOGICAL
OTHER
PROCEDURE
No Results Yet
520
Participants
Sacituzumab Tirumotecan (MK-2870) Versus Pemetrexed and Carboplatin Combination Therapy in Participants With Epidermal Growth Factor (EGFR)-Mutated, Advanced Nonsquamous Non-small Cell Lung Cancer (NSCLC) Who Have Progressed on Prior EGFR Tyrosine Kinase Inhibitors (MK-2870-009)
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2024-06-11
Completion:
2028-09-12
Conditions
Non-small Cell Lung Cancer (NSCLC)
Interventions
BIOLOGICAL
DRUG
No Results Yet
180
Participants
Benefits of Individual Physical Activity Intervention on Health-related Quality of Life in Participants With Chronic Lymphocytic Leukemia
Study Type:
OBSERVATIONAL
Last Updated:
2025-12-24
Start Date:
2024-05-27
Completion:
2026-09-30
Conditions
Leukemia, Lymphocytic, Chronic, B-Cell
Interventions
BEHAVIORAL
DRUG
No Results Yet
60
Participants
Erector Spinae Plane Block vs Quadratus Lumborum Block for Laparoscopic Nephrectomy
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2024-03-11
Completion:
2026-03-30
Conditions
Kidney Diseases
Kidney Failure
Interventions
OTHER
No Results Yet
320
Participants
Effect of Retatrutide Compared With Placebo in Participants With Type 2 Diabetes and Moderate or Severe Renal Impairment, With Inadequate Glycemic Control on Basal Insulin, With or Without Metformin and/or SGLT2 Inhibitor (TRANSCEND-T2D-3)
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2024-03-15
Completion:
2026-10-31
Conditions
Type 2 Diabetes
Interventions
DRUG
No Results Yet
40
Participants
Clinical and Radiographic Success Rate of Pulpotomy Versus Pulpectomy for Management of Primary Teeth With Deep Caries
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-24
Start Date:
2026-01-01
Completion:
2026-01-31
Conditions
Deep Caries
Interventions
PROCEDURE
No Results Yet
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